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147. Wang L, Jacobson O, Avdic D, Rotstein BH, Weiss ID, Collier L, Chen X, Vasdev N, Liang
SH (2015) Ortho-stabilized 18 F-azido click agents and their application in PET imaging with
single-stranded DNA aptamers. Angew Chem Int Ed 54(43):12777–12781
148. Kim D, Jeong YY, Jon S (2010) A drug-loaded aptamer-gold nanoparticle bioconjugate for
combined CT imaging and therapy of prostate cancer. ACS Nano 4(7):3689–3696
149. Li CH, Kuo TR, Su HJ, Lai WY, Yang PC, Chen JS, Wang DY, Wu YC, Chen CC
(2015) Fluorescence-guided probes of aptamer-targeted gold nanoparticles with computed
tomography imaging accesses for in vivo tumor resection. Sci Rep 5:15675
150. Wu M, Wang Y, Wang Y, Zhang M, Luo Y, Tang J, Wang Z, Wang D, Hao L, Wang Z (2017)
Paclitaxel-loaded and A10-3.2 aptamer-targeted poly(lactide-co-glycolic acid) nanobubbles
for ultrasound imaging and therapy of prostate cancer. Int J Nanomedicine 12:5313–5330
151. Zhang J, Smaga LP, Satyavolu NSR, Chan J, Lu Y (2017) DNA Aptamer-Based Activatable
Probes for Photoacoustic Imaging in Living Mice. J Am Chem Soc 139(48):17225–17228
152. Kang WJ, Lee J, Lee YS, Cho S, Ali BA, Al-Khedhairy AA, Heo H, Kim S (2015) Multimodal
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136:134–140
153. Petersen KE, Manangon E, Hood JL, Wickline SA, Fernandez DP, Johnson WP, Gale BK
(2014) A review of exosome separation techniques and characterization of B16-F10 mouse
melanoma exosomes with AF4-UV-MALS-DLS-TEM. Anal Bioanal Chem 406(30):7855–
7866
154. Zhang X, Yuan X, Shi H, Wu L, Qian H, Xu W (2015) Exosomes in cancer: small particle,
big player. J Hematol Oncol 8(1):83
155. Jalalian SH, Ramezani M, Jalalian SA, Abnous K, Taghdisi SM (2019) Exosomes, new
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156. Cheng N, Du D, Wang X, Liu D, Xu W, Luo Y, Lin Y (2019) Recent advances in biosensors
for detecting cancer-derived exosomes. Trends Biotechnol 37(11):1236–1254
157. Yu X, He L, Pentok M, Yang H, Yang Y, Li Z, He N, Deng Y, Li S, Liu T (2019) An
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158. Zhang Z, Tang C, Zhao L, Xu L, Zhou W, Dong Z, Yang Y, Xie Q, Fang X (2019) Aptamerbased fluorescence polarization assay for separation-free exosome quantification. Nanoscale
11(20):10106–10113
159. Jin D, Yang F, Zhang Y, Liu L, Zhou Y, Wang F, Zhang G-J (2018) ExoAPP: exosomeoriented, aptamer nanoprobe-enabled surface proteins profiling and detection. Anal Chem
90(24):14402–14411
160. Zhang Q, Wang F, Zhang H, Zhang Y, Liu M, Liu Y (2018) Universal Ti3C2 MXenes based
self-standard ratiometric fluorescence resonance energy transfer platform for highly sensitive
detection of exosomes. Anal Chem 90(21):12737–12744
161. Wang H, Chen H, Huang Z, Li T, Deng A, Kong J (2018) DNase I enzyme-aided fluorescence
signal amplification based on graphene oxide-DNA aptamer interactions for colorectal cancer
exosome detection. Talanta 184:219–226
162. Jiang Y, Shi M, Liu Y, Wan S, Cui C, Zhang L, Tan W (2017) Aptamer/AuNP Biosensor for
Colorimetric Profiling of Exosomal Proteins. Angew Chem Int Ed 56(39):11916–11920
163. Xia Y, Liu M, Wang L, Yan A, He W, Chen M, Lan J, Xu J, Guan L, Chen J (2017) A
visible and colorimetric aptasensor based on DNA-capped single-walled carbon nanotubes
for detection of exosomes. Biosens Bioelectron 92:8–15
164. Zhou Q, Rahimian A, Son K, Shin D-S, Patel T, Revzin A (2016) Development of an aptasensor
for electrochemical detection of exosomes. Methods 97:88–93
165. Wang S, Zhang L, Wan S, Cansiz S, Cui C, Liu Y, Cai R, Hong C, Teng IT, Shi M, Wu Y,
Dong Y, Tan W (2017) Aptasensor with Expanded Nucleotide Using DNA Nanotetrahedra
for Electrochemical Detection of Cancerous Exosomes. ACS Nano 11(4):3943–3949
Q. Lv et al.
146. Liu K, Song G, Zhang X, Li Q, Zhao Y, Zhou Y, Xiong R, Hu X, Tang Z, Feng G (2017)
PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma. World Journal of
Surgical Oncology 15(1):105
147. Wang L, Jacobson O, Avdic D, Rotstein BH, Weiss ID, Collier L, Chen X, Vasdev N, Liang
SH (2015) Ortho-stabilized 18 F-azido click agents and their application in PET imaging with
single-stranded DNA aptamers. Angew Chem Int Ed 54(43):12777–12781
148. Kim D, Jeong YY, Jon S (2010) A drug-loaded aptamer-gold nanoparticle bioconjugate for
combined CT imaging and therapy of prostate cancer. ACS Nano 4(7):3689–3696
149. Li CH, Kuo TR, Su HJ, Lai WY, Yang PC, Chen JS, Wang DY, Wu YC, Chen CC
(2015) Fluorescence-guided probes of aptamer-targeted gold nanoparticles with computed
tomography imaging accesses for in vivo tumor resection. Sci Rep 5:15675
150. Wu M, Wang Y, Wang Y, Zhang M, Luo Y, Tang J, Wang Z, Wang D, Hao L, Wang Z (2017)
Paclitaxel-loaded and A10-3.2 aptamer-targeted poly(lactide-co-glycolic acid) nanobubbles
for ultrasound imaging and therapy of prostate cancer. Int J Nanomedicine 12:5313–5330
151. Zhang J, Smaga LP, Satyavolu NSR, Chan J, Lu Y (2017) DNA Aptamer-Based Activatable
Probes for Photoacoustic Imaging in Living Mice. J Am Chem Soc 139(48):17225–17228
152. Kang WJ, Lee J, Lee YS, Cho S, Ali BA, Al-Khedhairy AA, Heo H, Kim S (2015) Multimodal
imaging probe for targeting cancer cells using uMUC-1 aptamer. Colloids Surf B Biointerfaces
136:134–140
153. Petersen KE, Manangon E, Hood JL, Wickline SA, Fernandez DP, Johnson WP, Gale BK
(2014) A review of exosome separation techniques and characterization of B16-F10 mouse
melanoma exosomes with AF4-UV-MALS-DLS-TEM. Anal Bioanal Chem 406(30):7855–
7866
154. Zhang X, Yuan X, Shi H, Wu L, Qian H, Xu W (2015) Exosomes in cancer: small particle,
big player. J Hematol Oncol 8(1):83
155. Jalalian SH, Ramezani M, Jalalian SA, Abnous K, Taghdisi SM (2019) Exosomes, new
biomarkers in early cancer detection. Anal Biochem 571:1–13
156. Cheng N, Du D, Wang X, Liu D, Xu W, Luo Y, Lin Y (2019) Recent advances in biosensors
for detecting cancer-derived exosomes. Trends Biotechnol 37(11):1236–1254
157. Yu X, He L, Pentok M, Yang H, Yang Y, Li Z, He N, Deng Y, Li S, Liu T (2019) An
aptamer-based new method for competitive fluorescence detection of exosomes. Nanoscale
11(33):15589–15595
158. Zhang Z, Tang C, Zhao L, Xu L, Zhou W, Dong Z, Yang Y, Xie Q, Fang X (2019) Aptamerbased fluorescence polarization assay for separation-free exosome quantification. Nanoscale
11(20):10106–10113
159. Jin D, Yang F, Zhang Y, Liu L, Zhou Y, Wang F, Zhang G-J (2018) ExoAPP: exosomeoriented, aptamer nanoprobe-enabled surface proteins profiling and detection. Anal Chem
90(24):14402–14411
160. Zhang Q, Wang F, Zhang H, Zhang Y, Liu M, Liu Y (2018) Universal Ti3C2 MXenes based
self-standard ratiometric fluorescence resonance energy transfer platform for highly sensitive
detection of exosomes. Anal Chem 90(21):12737–12744
161. Wang H, Chen H, Huang Z, Li T, Deng A, Kong J (2018) DNase I enzyme-aided fluorescence
signal amplification based on graphene oxide-DNA aptamer interactions for colorectal cancer
exosome detection. Talanta 184:219–226
162. Jiang Y, Shi M, Liu Y, Wan S, Cui C, Zhang L, Tan W (2017) Aptamer/AuNP Biosensor for
Colorimetric Profiling of Exosomal Proteins. Angew Chem Int Ed 56(39):11916–11920
163. Xia Y, Liu M, Wang L, Yan A, He W, Chen M, Lan J, Xu J, Guan L, Chen J (2017) A
visible and colorimetric aptasensor based on DNA-capped single-walled carbon nanotubes
for detection of exosomes. Biosens Bioelectron 92:8–15
164. Zhou Q, Rahimian A, Son K, Shin D-S, Patel T, Revzin A (2016) Development of an aptasensor
for electrochemical detection of exosomes. Methods 97:88–93
165. Wang S, Zhang L, Wan S, Cansiz S, Cui C, Liu Y, Cai R, Hong C, Teng IT, Shi M, Wu Y,
Dong Y, Tan W (2017) Aptasensor with Expanded Nucleotide Using DNA Nanotetrahedra
for Electrochemical Detection of Cancerous Exosomes. ACS Nano 11(4):3943–3949