270
Q. Lv et al.
29. Ostroff RM, Bigbee WL, Franklin W, Gold L, Mehan M, Miller YE, Pass HI, Rom WN,
Siegfried JM, Stewart A, Walker JJ, Weissfeld JL, Williams S, Zichi D, Brody EN (2010)
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for
early detection of lung cancer. PLoS ONE 5(12):e15003
30. Vaught JD, Bock C, Carter J, Fitzwater T, Otis M, Schneider D, Rolando J, Waugh S, Wilcox
SK, Eaton BE (2010) Expanding the chemistry of DNA for in vitro selection. J Am Chem
Soc 132(12):4141–4151
31. Baird GS, Nelson SK, Keeney TR, Stewart A, Williams S, Kraemer S, Peskind ER, Montine TJ
(2012) Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified
aptamer array. Am J Pathol 180(2):446–456
32. Webber J, Stone TC, Katilius E, Smith BC, Gordon B, Mason MD, Tabi Z, Brewis IA, Clayton
A (2014) Proteomics analysis of cancer exosomes using a novel modified aptamer-based array
(SOMAscan TM ) platform. Mol Cell Proteomics 13(4):1050–1064
33. Niu G, Chen X (2010) Vascular endothelial growth factor as an anti-angiogenic target for
cancer therapy. Curr Drug Targets 11(8):1000–1017
34. Crulhas BP, Karpik AE, Delella FK, Castro GR, Pedrosa VA (2017) Electrochemical aptamerbased biosensor developed to monitor PSA and VEGF released by prostate cancer cells. Anal
Bioanal Chem 409(29):6771–6780
35. Qureshi A, Gurbuz Y, Niazi JH (2015) Capacitive aptamer–antibody based sandwich assay
for the detection of VEGF cancer biomarker in serum. Sensors Actuat B Chem 209:645–651
36. Wang B, Akiba U, Anzai J-i (2017) Recent progress in nanomaterial-based electrochemical
biosensors for cancer biomarkers: A review. Molecules 22(7):1048
37. Shamsipur M, Farzin L, Amouzadeh Tabrizi M, Molaabasi F (2015) Highly sensitive label
free electrochemical detection of VGEF 165 tumor marker based on “signal off” and “signal
on” strategies using an anti-VEGF165 aptamer immobilized BSA-gold nanoclusters/ionic
liquid/glassy carbon electrode. Biosens Bioelectron 74:369–375
38. Amouzadeh Tabrizi M, Shamsipur M, Farzin L (2015) A high sensitive electrochemical
aptasensor for the determination of VEGF165 in serum of lung cancer patient. Biosens
Bioelectron 74:764–769
39. Ravalli A, Rivas L, De La Escosura-Muñiz A, Pons J, Merkoçi A, Marrazza G (2015) A DNA
aptasensor for electrochemical detection of vascular endothelial growth factor. J Nanosci
Nanotechno 15(5):3411–3416
40. Fu X-M, Liu Z-J, Cai S-X, Zhao Y-P, Wu D-Z, Li C-Y, Chen J-H (2016) Electrochemical
aptasensor for the detection of vascular endothelial growth factor (VEGF) based on DNAtemplated Ag/Pt bimetallic nanoclusters. Chin Chem Lett 27(6):920–926
41. Amouzadeh Tabrizi M, Shamsipur M, Saber R, Sarkar S (2017) Simultaneous determination of
CYC and VEGF165 tumor markers based on immobilization of flavin adenine dinucleotide
and thionine as probes on reduced graphene oxide-poly(amidoamine)/gold nanocomposite
modified dual working screen-printed electrode. Sensors Actuat B Chem 240:1174–1181
42. Da H, Liu H, Zheng Y, Yuan R, Chai Y (2018) A highly sensitive VEGF165 photoelectrochemical biosensor fabricated by assembly of aptamer bridged DNA networks. Biosens
Bioelectron 101:213–218
43. Wang Q-L, Cui H-F, Song X, Fan S-F, Chen L-L, Li M-M, Li Z-Y (2018) A label-free and
lectin-based sandwich aptasensor for detection of carcinoembryonic antigen. Sensors Actuat
B Chem 260:48–54
44. Gao Y, Song P, Li H, Jia H, Zhang B (2017) Elevated serum CEA levels are associated with
the explosive progression of lung adenocarcinoma harboring EGFR mutations. BMC Cancer
17(1):484
45. Nguyen HH, Park J, Kang S, Kim M (2015) Surface plasmon resonance: A versatile technique
for biosensor applications. Sensors 15(5):10481–10510
46. Guo C, Su F, Song Y, Hu B, Wang M, He L, Peng D, Zhang Z (2017) Aptamer-templated
silver nanoclusters embedded in zirconium metal–organic framework for bifunctional electrochemical and SPR aptasensors toward carcinoembryonic antigen. ACS Appl Mater Inter
9(47):41188–41199
Q. Lv et al.
29. Ostroff RM, Bigbee WL, Franklin W, Gold L, Mehan M, Miller YE, Pass HI, Rom WN,
Siegfried JM, Stewart A, Walker JJ, Weissfeld JL, Williams S, Zichi D, Brody EN (2010)
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for
early detection of lung cancer. PLoS ONE 5(12):e15003
30. Vaught JD, Bock C, Carter J, Fitzwater T, Otis M, Schneider D, Rolando J, Waugh S, Wilcox
SK, Eaton BE (2010) Expanding the chemistry of DNA for in vitro selection. J Am Chem
Soc 132(12):4141–4151
31. Baird GS, Nelson SK, Keeney TR, Stewart A, Williams S, Kraemer S, Peskind ER, Montine TJ
(2012) Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified
aptamer array. Am J Pathol 180(2):446–456
32. Webber J, Stone TC, Katilius E, Smith BC, Gordon B, Mason MD, Tabi Z, Brewis IA, Clayton
A (2014) Proteomics analysis of cancer exosomes using a novel modified aptamer-based array
(SOMAscan TM ) platform. Mol Cell Proteomics 13(4):1050–1064
33. Niu G, Chen X (2010) Vascular endothelial growth factor as an anti-angiogenic target for
cancer therapy. Curr Drug Targets 11(8):1000–1017
34. Crulhas BP, Karpik AE, Delella FK, Castro GR, Pedrosa VA (2017) Electrochemical aptamerbased biosensor developed to monitor PSA and VEGF released by prostate cancer cells. Anal
Bioanal Chem 409(29):6771–6780
35. Qureshi A, Gurbuz Y, Niazi JH (2015) Capacitive aptamer–antibody based sandwich assay
for the detection of VEGF cancer biomarker in serum. Sensors Actuat B Chem 209:645–651
36. Wang B, Akiba U, Anzai J-i (2017) Recent progress in nanomaterial-based electrochemical
biosensors for cancer biomarkers: A review. Molecules 22(7):1048
37. Shamsipur M, Farzin L, Amouzadeh Tabrizi M, Molaabasi F (2015) Highly sensitive label
free electrochemical detection of VGEF 165 tumor marker based on “signal off” and “signal
on” strategies using an anti-VEGF165 aptamer immobilized BSA-gold nanoclusters/ionic
liquid/glassy carbon electrode. Biosens Bioelectron 74:369–375
38. Amouzadeh Tabrizi M, Shamsipur M, Farzin L (2015) A high sensitive electrochemical
aptasensor for the determination of VEGF165 in serum of lung cancer patient. Biosens
Bioelectron 74:764–769
39. Ravalli A, Rivas L, De La Escosura-Muñiz A, Pons J, Merkoçi A, Marrazza G (2015) A DNA
aptasensor for electrochemical detection of vascular endothelial growth factor. J Nanosci
Nanotechno 15(5):3411–3416
40. Fu X-M, Liu Z-J, Cai S-X, Zhao Y-P, Wu D-Z, Li C-Y, Chen J-H (2016) Electrochemical
aptasensor for the detection of vascular endothelial growth factor (VEGF) based on DNAtemplated Ag/Pt bimetallic nanoclusters. Chin Chem Lett 27(6):920–926
41. Amouzadeh Tabrizi M, Shamsipur M, Saber R, Sarkar S (2017) Simultaneous determination of
CYC and VEGF165 tumor markers based on immobilization of flavin adenine dinucleotide
and thionine as probes on reduced graphene oxide-poly(amidoamine)/gold nanocomposite
modified dual working screen-printed electrode. Sensors Actuat B Chem 240:1174–1181
42. Da H, Liu H, Zheng Y, Yuan R, Chai Y (2018) A highly sensitive VEGF165 photoelectrochemical biosensor fabricated by assembly of aptamer bridged DNA networks. Biosens
Bioelectron 101:213–218
43. Wang Q-L, Cui H-F, Song X, Fan S-F, Chen L-L, Li M-M, Li Z-Y (2018) A label-free and
lectin-based sandwich aptasensor for detection of carcinoembryonic antigen. Sensors Actuat
B Chem 260:48–54
44. Gao Y, Song P, Li H, Jia H, Zhang B (2017) Elevated serum CEA levels are associated with
the explosive progression of lung adenocarcinoma harboring EGFR mutations. BMC Cancer
17(1):484
45. Nguyen HH, Park J, Kang S, Kim M (2015) Surface plasmon resonance: A versatile technique
for biosensor applications. Sensors 15(5):10481–10510
46. Guo C, Su F, Song Y, Hu B, Wang M, He L, Peng D, Zhang Z (2017) Aptamer-templated
silver nanoclusters embedded in zirconium metal–organic framework for bifunctional electrochemical and SPR aptasensors toward carcinoembryonic antigen. ACS Appl Mater Inter
9(47):41188–41199