Leptospira interrogans. Infect Immun 72
(2):742–749
15. Dhandapani G, Sikha T, Pinto SM, Kiran
Kumar M, Patel K, Kumar M, Kumar V,
Tennyson J, Satheeshkumar PK, Gowda H,
Keshava Prasad TS, Madanan MG (2018) Proteomic approach and expression analysis
revealed the differential expression of predicted
leptospiral proteases capable of ECM degradation. Biochim Biophys Acta Proteins Proteom
1866(5–6):712–721.
https://doi.org/10.
1016/j.bbapap.2018.04.006
16. Adhikarla H, Wunder EA Jr, Mechaly AE,
Mehta S, Wang Z, Santos L, Bisht V,
Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M,
Buschiazzo A, Ko AI (2018) Lvr, a Signaling
system that controls global gene regulation and
virulence in pathogenic Leptospira. Front Cell
Infect Microbiol 8:45. https://doi.org/10.
3389/fcimb.2018.00045
17. Fraser T, Brown PD (2017) Temperature and
oxidative stress as triggers for virulence gene
expression in pathogenic Leptospira spp. Front
Microbiol 8:783. https://doi.org/10.3389/
fmicb.2017.00783
18. Lo M, Bulach DM, Powell DR, Haake DA,
Matsunaga J, Paustian ML, Zuerner RL,
Adler B (2006) Effects of temperature on
gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome
microarrays. Infect Immun 74(10):5848–5859
19. Patarakul K, Lo M, Adler B (2010) Global
transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to
serum. BMC Microbiol 10:31. https://doi.
org/10.1186/1471-2180-10-31
20. Nally JE, Chow E, Fishbein MC, Blanco DR,
Lovett MA (2005) Changes in lipopolysaccharide O antigen distinguish acute versus chronic
Leptospira interrogans infections. Infect
Immun 73(6):3251–3260. https://doi.org/
10.1128/IAI.73.6.3251-3260.2005
21. Nally JE, Grassmann AA, Planchon S,
Sergeant K, Renaut J, Seshu J, McBride AJ,
Caimano MJ (2017) Pathogenic Leptospires
modulate protein expression and posttranslational modifications in response to
mammalian host signals. Front Cell Infect
Microbiol 7:362. https://doi.org/10.3389/
fcimb.2017.00362
22. Nally JE, Monahan AM, Miller IS, BonillaSantiago R, Souda P, Whitelegge JP (2011)
Comparative proteomic analysis of differentially expressed proteins in the urine of reservoir hosts of leptospirosis. PLoS One 6(10):
e26046. https://doi.org/10.1371/journal.
pone.0026046
23. Nally JE, Timoney JF, Stevenson B (2001)
Temperature-regulated protein synthesis by
Leptospira interrogans. Infect Immun 69
(1):400–404. https://doi.org/10.1128/IAI.
69.1.400-404.2001
24. Nally JE, Whitelegge JP, Bassilian S, Blanco
DR, Lovett MA (2007) Characterization of
the outer membrane proteome of Leptospira
interrogans expressed during acute lethal infection. Infect Immun 75(2):766–773. https://
doi.org/10.1128/IAI.00741-06
25. Johnson RC, Walby J, Henry RA, Auran NE
(1973) Cultivation of parasitic leptospires:
effect of pyruvate. Appl Microbiol 26
(1):118–119
242
Andre Alex Grassmann and Melissa J. Caimano
(2):742–749
15. Dhandapani G, Sikha T, Pinto SM, Kiran
Kumar M, Patel K, Kumar M, Kumar V,
Tennyson J, Satheeshkumar PK, Gowda H,
Keshava Prasad TS, Madanan MG (2018) Proteomic approach and expression analysis
revealed the differential expression of predicted
leptospiral proteases capable of ECM degradation. Biochim Biophys Acta Proteins Proteom
1866(5–6):712–721.
https://doi.org/10.
1016/j.bbapap.2018.04.006
16. Adhikarla H, Wunder EA Jr, Mechaly AE,
Mehta S, Wang Z, Santos L, Bisht V,
Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M,
Buschiazzo A, Ko AI (2018) Lvr, a Signaling
system that controls global gene regulation and
virulence in pathogenic Leptospira. Front Cell
Infect Microbiol 8:45. https://doi.org/10.
3389/fcimb.2018.00045
17. Fraser T, Brown PD (2017) Temperature and
oxidative stress as triggers for virulence gene
expression in pathogenic Leptospira spp. Front
Microbiol 8:783. https://doi.org/10.3389/
fmicb.2017.00783
18. Lo M, Bulach DM, Powell DR, Haake DA,
Matsunaga J, Paustian ML, Zuerner RL,
Adler B (2006) Effects of temperature on
gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome
microarrays. Infect Immun 74(10):5848–5859
19. Patarakul K, Lo M, Adler B (2010) Global
transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to
serum. BMC Microbiol 10:31. https://doi.
org/10.1186/1471-2180-10-31
20. Nally JE, Chow E, Fishbein MC, Blanco DR,
Lovett MA (2005) Changes in lipopolysaccharide O antigen distinguish acute versus chronic
Leptospira interrogans infections. Infect
Immun 73(6):3251–3260. https://doi.org/
10.1128/IAI.73.6.3251-3260.2005
21. Nally JE, Grassmann AA, Planchon S,
Sergeant K, Renaut J, Seshu J, McBride AJ,
Caimano MJ (2017) Pathogenic Leptospires
modulate protein expression and posttranslational modifications in response to
mammalian host signals. Front Cell Infect
Microbiol 7:362. https://doi.org/10.3389/
fcimb.2017.00362
22. Nally JE, Monahan AM, Miller IS, BonillaSantiago R, Souda P, Whitelegge JP (2011)
Comparative proteomic analysis of differentially expressed proteins in the urine of reservoir hosts of leptospirosis. PLoS One 6(10):
e26046. https://doi.org/10.1371/journal.
pone.0026046
23. Nally JE, Timoney JF, Stevenson B (2001)
Temperature-regulated protein synthesis by
Leptospira interrogans. Infect Immun 69
(1):400–404. https://doi.org/10.1128/IAI.
69.1.400-404.2001
24. Nally JE, Whitelegge JP, Bassilian S, Blanco
DR, Lovett MA (2007) Characterization of
the outer membrane proteome of Leptospira
interrogans expressed during acute lethal infection. Infect Immun 75(2):766–773. https://
doi.org/10.1128/IAI.00741-06
25. Johnson RC, Walby J, Henry RA, Auran NE
(1973) Cultivation of parasitic leptospires:
effect of pyruvate. Appl Microbiol 26
(1):118–119
242
Andre Alex Grassmann and Melissa J. Caimano