12 Nonlinear Label-Free Super-Resolution Microscopy Using Structured Illumination
311
74. P.-J. Su, W.-L. Chen, T.-H. Li, C.-K. Chou, T.-H. Chen, Y.-Y. Ho, C.-H. Huang, S.-J. Chang,
Y.-Y. Huang, H.-S. Lee, C.-Y. Dong, The discrimination of type I and type II collagen and the
label-free imaging of engineered cartilage tissue. Biomaterials 31(36), 9415–9421 (2010)
75. R. Cicchi, D. Kapsokalyvas, V. De Giorgi, V. Maio, A. Van Wiechen, D. Massi, T. Lotti,
F.S. Pavone, Scoring of collagen organization in healthy and diseased human dermis by
multiphoton microscopy. J. Biophotonics 3(1–2), 34–43 (2010)
76. S. Zhuo, J. Yan, G. Chen, J. Chen, Y. Liu, J. Lu, X. Zhu, X. Jiang, S. Xie, Label-free monitoring
of colonic cancer progression using multiphoton microscopy. Biomed. Opt. Express 2(3),
615–619 (2011)
77. X. Wu, G. Chen, J. Lu, W. Zhu, J. Qiu, J. Chen, S. Xie, S. Zhuo, J. Yan, Label-free detection
of breast masses using multiphoton microscopy. PLoS One 8(6), e65933 (2013)
78. M.J. Huttunen, A. Hassan, C.W. McCloskey, S. Fasih, J. Upham, B.C. Vanderhyden, R.W.
Boyd, S. Murugkar, Automated classification of multiphoton microscopy images of ovarian
tissue using deep learning. J. Biomed. Opt. 23(6), 066002 (2018)
79. L.M. Haupert, G.J. Simpson, Chirality in Nonlinear Optics. Annu. Rev. Phys. Chem. 60(1),
345–365 (2009)
80. X. Chen, C. Raggio, P.J. Campagnola, Second-harmonic generation circular dichroism studies
of osteogenesis imperfecta. Opt. Lett. 37(18), 3837–3839 (2012)
81. H. Lee, M.J. Huttunen, K.-J. Hsu, M. Partanen, G.-Y. Zhuo, M. Kauranen, S.-W. Chu, Chiral
imaging of collagen by second-harmonic generation circular dichroism. Biomed. Opt. Express
4(6), 909–916 (2013)
82. G.Y. Zhuo, H. Lee, K.J. Hsu, M.J. Huttunen, M. Kauranen, Y.Y. Lin, S.-W. Chu, Threedimensional structural imaging of starch granules by second-harmonic generation circular
dichroism. J. Microsc. 253(3), 183–190 (2014)
83. M.J. Huttunen, M. Partanen, G. Bautista, S.-W. Chu, M. Kauranen, Nonlinear optical activity
effects in complex anisotropic three-dimensional media. Opt. Mater. Express 5(1), 11–21
(2015)
84. M.Y. Chen, M.J. Huttunen, C.W. Kan, G.Deka, Y.Y. Lin, Y.C. W., M.J. Wu, H.L. Liu, S.-W.
Chu, Resonant nonlinear microscopy reveals changes in molecular level chirality in native
biological tissues. Opt. Commun. 422, 56–63 (2018)
85. S. Witte, A. Negrean, J.C. Lodder, C.P.J. De Kock, G.T. Silva, H.D. Mansvelder, M.L.
Groot, Label-free live brain imaging and targeted patching with third-harmonic generation
microscopy. Proc. Natl. Acad. Sci. 108(15), 5970–5975 (2011)
86. G. de Wit, J.S.H. Danial, P. Kukura, M.I. Wallace, Dynamic label-free imaging of lipid
nanodomains. Proc. Natl. Acad. Sci. 112(40), 12299–12303 (2015)
87. T.T. Le, I.M. Langohr, M.J. Locker, M. Sturek, J.-X. Cheng, Label-free molecular imaging
of atherosclerotic lesions using multimodal nonlinear optical microscopy. J. Biomed. Opt.
12(5), 54007 (2007)
88. H.A. Rinia, K.N.J. Burger, M. Bonn, M. Müller, Quantitative label-free imaging of lipid composition and packing of individual cellular lipid droplets using multiplex CARS microscopy.
Biophys. J. 95(10), 4908–4914 (2008)
89. T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B.F. Romeike,
B.R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, J. Popp, Expanding multimodal microscopy by high spectral resolution coherent anti-stokes Raman scattering imaging
for clinical disease diagnostics. Anal. Chem. 85(14), 6703–6715 (2013)
90. G. Bautista, M.J. Huttunen, J. Mäkitalo, J.M. Kontio, J. Simonen, M. Kauranen, Secondharmonic generation imaging of metal nano-objects with cylindrical vector beams. Nano
Lett. 12(6), 3207–3212 (2012)
91. M. Kauranen, A.V. Zayats, Nonlinear plasmonics. Nat. Photonics 6, 737–748 (2012)
92. H. Kim, T. Sheps, P.G. Collins, E.O. Potma, Nonlinear optical imaging of individual carbon
nanotubes with four-wave-mixing microscopy. Nano Lett. 9(8), 2991–2995 (2009)
93. A. Saynatjoki, L. Karvonen, J. Riikonen, W. Kim, S. Mehravar, R.A. Norwood, N. Peyghambarian, H. Lipsanen, K. Kieu, Rapid large-area multiphoton microscopy for characterization
of graphene. ACS Nano 7(10), 8441–8446 (2013)
311
74. P.-J. Su, W.-L. Chen, T.-H. Li, C.-K. Chou, T.-H. Chen, Y.-Y. Ho, C.-H. Huang, S.-J. Chang,
Y.-Y. Huang, H.-S. Lee, C.-Y. Dong, The discrimination of type I and type II collagen and the
label-free imaging of engineered cartilage tissue. Biomaterials 31(36), 9415–9421 (2010)
75. R. Cicchi, D. Kapsokalyvas, V. De Giorgi, V. Maio, A. Van Wiechen, D. Massi, T. Lotti,
F.S. Pavone, Scoring of collagen organization in healthy and diseased human dermis by
multiphoton microscopy. J. Biophotonics 3(1–2), 34–43 (2010)
76. S. Zhuo, J. Yan, G. Chen, J. Chen, Y. Liu, J. Lu, X. Zhu, X. Jiang, S. Xie, Label-free monitoring
of colonic cancer progression using multiphoton microscopy. Biomed. Opt. Express 2(3),
615–619 (2011)
77. X. Wu, G. Chen, J. Lu, W. Zhu, J. Qiu, J. Chen, S. Xie, S. Zhuo, J. Yan, Label-free detection
of breast masses using multiphoton microscopy. PLoS One 8(6), e65933 (2013)
78. M.J. Huttunen, A. Hassan, C.W. McCloskey, S. Fasih, J. Upham, B.C. Vanderhyden, R.W.
Boyd, S. Murugkar, Automated classification of multiphoton microscopy images of ovarian
tissue using deep learning. J. Biomed. Opt. 23(6), 066002 (2018)
79. L.M. Haupert, G.J. Simpson, Chirality in Nonlinear Optics. Annu. Rev. Phys. Chem. 60(1),
345–365 (2009)
80. X. Chen, C. Raggio, P.J. Campagnola, Second-harmonic generation circular dichroism studies
of osteogenesis imperfecta. Opt. Lett. 37(18), 3837–3839 (2012)
81. H. Lee, M.J. Huttunen, K.-J. Hsu, M. Partanen, G.-Y. Zhuo, M. Kauranen, S.-W. Chu, Chiral
imaging of collagen by second-harmonic generation circular dichroism. Biomed. Opt. Express
4(6), 909–916 (2013)
82. G.Y. Zhuo, H. Lee, K.J. Hsu, M.J. Huttunen, M. Kauranen, Y.Y. Lin, S.-W. Chu, Threedimensional structural imaging of starch granules by second-harmonic generation circular
dichroism. J. Microsc. 253(3), 183–190 (2014)
83. M.J. Huttunen, M. Partanen, G. Bautista, S.-W. Chu, M. Kauranen, Nonlinear optical activity
effects in complex anisotropic three-dimensional media. Opt. Mater. Express 5(1), 11–21
(2015)
84. M.Y. Chen, M.J. Huttunen, C.W. Kan, G.Deka, Y.Y. Lin, Y.C. W., M.J. Wu, H.L. Liu, S.-W.
Chu, Resonant nonlinear microscopy reveals changes in molecular level chirality in native
biological tissues. Opt. Commun. 422, 56–63 (2018)
85. S. Witte, A. Negrean, J.C. Lodder, C.P.J. De Kock, G.T. Silva, H.D. Mansvelder, M.L.
Groot, Label-free live brain imaging and targeted patching with third-harmonic generation
microscopy. Proc. Natl. Acad. Sci. 108(15), 5970–5975 (2011)
86. G. de Wit, J.S.H. Danial, P. Kukura, M.I. Wallace, Dynamic label-free imaging of lipid
nanodomains. Proc. Natl. Acad. Sci. 112(40), 12299–12303 (2015)
87. T.T. Le, I.M. Langohr, M.J. Locker, M. Sturek, J.-X. Cheng, Label-free molecular imaging
of atherosclerotic lesions using multimodal nonlinear optical microscopy. J. Biomed. Opt.
12(5), 54007 (2007)
88. H.A. Rinia, K.N.J. Burger, M. Bonn, M. Müller, Quantitative label-free imaging of lipid composition and packing of individual cellular lipid droplets using multiplex CARS microscopy.
Biophys. J. 95(10), 4908–4914 (2008)
89. T. Meyer, M. Chemnitz, M. Baumgartl, T. Gottschall, T. Pascher, C. Matthäus, B.F. Romeike,
B.R. Brehm, J. Limpert, A. Tünnermann, M. Schmitt, B. Dietzek, J. Popp, Expanding multimodal microscopy by high spectral resolution coherent anti-stokes Raman scattering imaging
for clinical disease diagnostics. Anal. Chem. 85(14), 6703–6715 (2013)
90. G. Bautista, M.J. Huttunen, J. Mäkitalo, J.M. Kontio, J. Simonen, M. Kauranen, Secondharmonic generation imaging of metal nano-objects with cylindrical vector beams. Nano
Lett. 12(6), 3207–3212 (2012)
91. M. Kauranen, A.V. Zayats, Nonlinear plasmonics. Nat. Photonics 6, 737–748 (2012)
92. H. Kim, T. Sheps, P.G. Collins, E.O. Potma, Nonlinear optical imaging of individual carbon
nanotubes with four-wave-mixing microscopy. Nano Lett. 9(8), 2991–2995 (2009)
93. A. Saynatjoki, L. Karvonen, J. Riikonen, W. Kim, S. Mehravar, R.A. Norwood, N. Peyghambarian, H. Lipsanen, K. Kieu, Rapid large-area multiphoton microscopy for characterization
of graphene. ACS Nano 7(10), 8441–8446 (2013)