Table 2.1 Summary of radiolabeled inorganic nanoparticles employed for in vivo molecular
imaging
Type of
nanoparticle
Radioisotope Labeling
method
Imaging modality
References
Iron oxide
NPs
99m
Tc
Chelator-based SPECT/MRI
[36]
125
I
SPECT
[37]
131
I
[ 38, 39]
111
In
[40, 41]
188
Re
[42]
64
Cu
PET/CT/MRI
[44, 45,
46]
68
Ga
PET/MRI
[47]
18
F
PET/CT/MRI/FL
[48]
89
Zr
Chelator-free
PET/CT
[49]
69
Ge
PET/MRI
[50]
72
As
PET/MRI
[52]
51
Cr
SPECT
[183]
Gold NPs
99m
Tc
Chelator-based SPECT/CT
[66]
89
Zr
PET
[71]
64
Cu
PET/CT
[69, 70]
Chelator-free
PET/CT
[68, 73]
198
Au
SPECT/FL
[70]
111
In
SPECT/CT
[184]
Quantum dots
99m
Tc
Chelator-based SPECT
[100]
125
I
SPECT/CT
[101]
64
Cu
PET/FL
[103]
18
F
[ 104]
64
Cu
Chelator-free
PET/CL
[110]
65
Zn
SPECT
[183]
111
In
SPECT/FL
[185]
109
Cd
[18]
125m
Te
SPECT/CT/FL
[186]
Silica NPs
124
I
Chelator-based PET/CT
[119]
64
Cu
[128, 129]
Chelator-free
[130]
68
Ga
[130]
89
Zr
[130, 131,
21]
111
In
[130]
90
Y
[ 115–117,
130]
(continued)
2 Exogenous Radionanomedicine: Inorganic Nanomaterials
35