Chapter 22
Molecular Imaging Using
Radionanomedicine
Yong-il Kim and Dong Soo Lee
Abstract Nanoparticles (NPs) have recently attracted great attention as biomedical
imaging agents. Many types of NPs have been investigated with combinations of
various molecular targeting groups. In addition, multiplex imaging has been studied
with NPs, including surface-enhanced Raman scattering (SERS) NPs.
Single-photon emission computed tomography (SPECT) or positron emission
tomography (PET) by molecularly targeted, radiolabeled NPs provides several
benefits over usual imaging probes in the aspect of sensitivity and quantitation. In
addition, multimodal imaging probes that are combinations of both
radionuclide-based and non-radionuclide-based imaging approaches, such as optical imaging or magnetic resonance imaging (MRI), could be applied to next
medical studies. Furthermore, molecularly targeted probes which could be identified by more than three imaging modalities are possible. In conclusion, nanotechnologies promise to extend the limitations of current molecular imaging techniques,
and nanomedicine may play an important role in the future.
Y. Kim (&)
Department of Nuclear Medicine, Asan Medical Center,
University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
e-mail: kyi821209@naver.com
D. S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: dsl@snu.ac.kr
D. S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
Seoul National University, Seoul 03080, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_22
411
Molecular Imaging Using
Radionanomedicine
Yong-il Kim and Dong Soo Lee
Abstract Nanoparticles (NPs) have recently attracted great attention as biomedical
imaging agents. Many types of NPs have been investigated with combinations of
various molecular targeting groups. In addition, multiplex imaging has been studied
with NPs, including surface-enhanced Raman scattering (SERS) NPs.
Single-photon emission computed tomography (SPECT) or positron emission
tomography (PET) by molecularly targeted, radiolabeled NPs provides several
benefits over usual imaging probes in the aspect of sensitivity and quantitation. In
addition, multimodal imaging probes that are combinations of both
radionuclide-based and non-radionuclide-based imaging approaches, such as optical imaging or magnetic resonance imaging (MRI), could be applied to next
medical studies. Furthermore, molecularly targeted probes which could be identified by more than three imaging modalities are possible. In conclusion, nanotechnologies promise to extend the limitations of current molecular imaging techniques,
and nanomedicine may play an important role in the future.
Y. Kim (&)
Department of Nuclear Medicine, Asan Medical Center,
University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
e-mail: kyi821209@naver.com
D. S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: dsl@snu.ac.kr
D. S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
Seoul National University, Seoul 03080, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_22
411