Fig. 19.7 Strategies for NPs to avoid MPS (or RES) recognition and prolong blood circulation.
PEGylation is a classic strategy. The attachment of PEG to the surface makes a hydrating layer to
inhibit protein corona formation. An active stealth strategy includes attachment of a self CD47
peptides, which makes macrophages consider the NPs as ‘self’ so that the NPs escape
phagocytosis. Coating of NPs with biological cell membranes obtained from autologous
leukocytes and red blood cells (RBC) provides a biomimetic surface shown to prolong in vivo
circulation substantially. Reproduced with permission [34]
358
H.-J. Im
PEGylation is a classic strategy. The attachment of PEG to the surface makes a hydrating layer to
inhibit protein corona formation. An active stealth strategy includes attachment of a self CD47
peptides, which makes macrophages consider the NPs as ‘self’ so that the NPs escape
phagocytosis. Coating of NPs with biological cell membranes obtained from autologous
leukocytes and red blood cells (RBC) provides a biomimetic surface shown to prolong in vivo
circulation substantially. Reproduced with permission [34]
358
H.-J. Im