already entered into clinical trials in 2011 (NCT01266096, NCT02106598). These
NPs are functionalized with near infrared (NIR) dye, cyclic RGD, and radioisotopes
for multimodal targeted imaging of cancer.
With HD of 6–8 nm and neutral charge, the NPs can be cleared through kidneys
effectively with sufficiently long blood circulation time (half-life = 190 min). In a
melanoma xenograft mouse model, the NPs showed the tumor uptake of only 2.0%
ID/g, but tumor to muscle ratio was as high as five [12]. In the first report of the
human clinical trial of C dots, the NPs were cleared out by the kidneys, and there
Fig. 19.2 The structure of the filtration barriers in the glomerulus. Reproduced with permission [2]
350
H.-J. Im
NPs are functionalized with near infrared (NIR) dye, cyclic RGD, and radioisotopes
for multimodal targeted imaging of cancer.
With HD of 6–8 nm and neutral charge, the NPs can be cleared through kidneys
effectively with sufficiently long blood circulation time (half-life = 190 min). In a
melanoma xenograft mouse model, the NPs showed the tumor uptake of only 2.0%
ID/g, but tumor to muscle ratio was as high as five [12]. In the first report of the
human clinical trial of C dots, the NPs were cleared out by the kidneys, and there
Fig. 19.2 The structure of the filtration barriers in the glomerulus. Reproduced with permission [2]
350
H.-J. Im