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adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)coated nanocarriers. Nat. Nanotechnol. 11(4), 372–377 (2016)
29. S. Ritz, S. Schöttler, N. Kotman, G. Baier, A. Musyanovych, J. Kuharev et al., Protein corona
of nanoparticles: distinct proteins regulate the cellular uptake. Biomacromolecules 16(4),
1311–1321 (2015)
30. E. Harrison, J.R. Nicol, M. Macias-Montero, G.A. Burke, J.A. Coulter, B.J. Meenan et al., A
comparison of gold nanoparticle surface co-functionalization approaches using Polyethylene
Glycol (PEG) and the effect on stability, non-specific protein adsorption and internalization.
Mater Sci. Eng. C Mater Biol. Appl. 62, 710–718 (2016)
31. K. Peynshaert, S.J. Soenen, B.B. Manshian, S.H. Doak, K. Braeckmans, S.C. De Smedt et al.,
Coating of quantum dots strongly defines their effect on lysosomal health and autophagy.
Acta Biomater. 48, 195–205 (2017)
32. J. Wolfram, Y. Yang, J. Shen, A. Moten, C. Chen, H. Shen et al., The nano-plasma interface:
implications of the protein corona. Coll. Surf. B Biointerfaces 124, 17–24 (2014)
33. L. Sanchez, Y. Yi, Y. Yu, Effect of partial PEGylation on particle uptake by macrophages.
Nanoscale 9(1), 288–297 (2017)
34. G. Settanni, J. Zhou, T. Suo, S. Schöttler, K. Landfester, F. Schmid et al., Protein corona
composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates
strongly with the amino acid composition of the protein surface. Nanoscale 9(6), 2138–2144
(2017)
35. S. Mondini, M. Leonzino, C. Drago, A.M. Ferretti, S. Usseglio, D. Maggioni et al.,
Zwitterion-coated iron oxide nanoparticles: surface chemistry and intracellular uptake by
hepatocarcinoma (HepG2) cells. Langmuir 31(26), 7381–7390 (2015)
36. Q. Shao, S. Jiang, Molecular understanding and design of zwitterionic materials. Adv. Mater.
27(1), 15–26 (2015)
37. A.S. Abu Lila, H. Kiwada, T. Ishida, The accelerated blood clearance (ABC) phenomenon:
clinical challenge and approaches to manage. J. Control Release 172(1), 38–47 (2013)
38. T. Shimizu, T. Ishida, H. Kiwada, Transport of PEGylated liposomes from the splenic
marginal zone to the follicle in the induction phase of the accelerated blood clearance
phenomenon. Immunobiology 218(5), 725–732 (2013)
39. N.J. Ganson, T.J. Povsic, B.A. Sullenger, J.H. Alexander, S.L. Zelenkofske, J.M. Sailstad
et al., Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions
to pegnivacogin, a PEGylated RNA aptamer. J. Allergy Clin. Immunol. 137(5):1610–1613.e7
(2016)
40. P. Zhang, F. Sun, S. Liu, S. Jiang, Anti-PEG antibodies in the clinic: current issues and
beyond PEGylation. J. Control Release 244(Pt B):184–193 (2016)
41. J.W. Lee, Y.J. Lee, U.C. Shin, S.W. Kim, B.I. Kim, K.C. Lee et al., Improved
pharmacokinetics following PEGylation and dimerization of a c(RGD-ACH-K) conjugate
used for tumor positron emission tomography imaging. Cancer Biother. Radiopharm. 31(8),
295–301 (2016)
42. Y.K. Lee, J.M. Jeong, L. Hoigebazar, B.Y. Yang, Y.S. Lee, B.C. Lee et al., Nanoparticles
modified by encapsulation of ligands with a long alkyl chain to affect multispecific and
multimodal imaging. J. Nucl. Med. 53(9), 1462–1470 (2012)
43. Y.S. Lee, Y.I. Kim, D.S. Lee, Future perspectives of radionanomedicine using the novel
micelle-encapsulation method for surface modification. Nucl. Med. Mol. Imaging 49(3), 170–
173 (2015)
44. B.Y. Yang, S.H. Moon, S.R. Seelam, M.J. Jeon, Y.S. Lee, D.S. Lee et al., Development of a
multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized
amphiphiles for lymph node imaging. Nanomed. (Lond). 10(12), 1899–1910 (2015)
45. S.H. Moon, B.Y. Yang, Y.J. Kim, M.K. Hong, Y.S. Lee, D.S. Lee et al., Development of a
complementary PET/MR dual-modal imaging probe for targeting prostate-specific membrane
antigen (PSMA). Nanomedicine 12(4), 871–879 (2016)
344
D. S. Lee and Y.-S. Lee
adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)coated nanocarriers. Nat. Nanotechnol. 11(4), 372–377 (2016)
29. S. Ritz, S. Schöttler, N. Kotman, G. Baier, A. Musyanovych, J. Kuharev et al., Protein corona
of nanoparticles: distinct proteins regulate the cellular uptake. Biomacromolecules 16(4),
1311–1321 (2015)
30. E. Harrison, J.R. Nicol, M. Macias-Montero, G.A. Burke, J.A. Coulter, B.J. Meenan et al., A
comparison of gold nanoparticle surface co-functionalization approaches using Polyethylene
Glycol (PEG) and the effect on stability, non-specific protein adsorption and internalization.
Mater Sci. Eng. C Mater Biol. Appl. 62, 710–718 (2016)
31. K. Peynshaert, S.J. Soenen, B.B. Manshian, S.H. Doak, K. Braeckmans, S.C. De Smedt et al.,
Coating of quantum dots strongly defines their effect on lysosomal health and autophagy.
Acta Biomater. 48, 195–205 (2017)
32. J. Wolfram, Y. Yang, J. Shen, A. Moten, C. Chen, H. Shen et al., The nano-plasma interface:
implications of the protein corona. Coll. Surf. B Biointerfaces 124, 17–24 (2014)
33. L. Sanchez, Y. Yi, Y. Yu, Effect of partial PEGylation on particle uptake by macrophages.
Nanoscale 9(1), 288–297 (2017)
34. G. Settanni, J. Zhou, T. Suo, S. Schöttler, K. Landfester, F. Schmid et al., Protein corona
composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates
strongly with the amino acid composition of the protein surface. Nanoscale 9(6), 2138–2144
(2017)
35. S. Mondini, M. Leonzino, C. Drago, A.M. Ferretti, S. Usseglio, D. Maggioni et al.,
Zwitterion-coated iron oxide nanoparticles: surface chemistry and intracellular uptake by
hepatocarcinoma (HepG2) cells. Langmuir 31(26), 7381–7390 (2015)
36. Q. Shao, S. Jiang, Molecular understanding and design of zwitterionic materials. Adv. Mater.
27(1), 15–26 (2015)
37. A.S. Abu Lila, H. Kiwada, T. Ishida, The accelerated blood clearance (ABC) phenomenon:
clinical challenge and approaches to manage. J. Control Release 172(1), 38–47 (2013)
38. T. Shimizu, T. Ishida, H. Kiwada, Transport of PEGylated liposomes from the splenic
marginal zone to the follicle in the induction phase of the accelerated blood clearance
phenomenon. Immunobiology 218(5), 725–732 (2013)
39. N.J. Ganson, T.J. Povsic, B.A. Sullenger, J.H. Alexander, S.L. Zelenkofske, J.M. Sailstad
et al., Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions
to pegnivacogin, a PEGylated RNA aptamer. J. Allergy Clin. Immunol. 137(5):1610–1613.e7
(2016)
40. P. Zhang, F. Sun, S. Liu, S. Jiang, Anti-PEG antibodies in the clinic: current issues and
beyond PEGylation. J. Control Release 244(Pt B):184–193 (2016)
41. J.W. Lee, Y.J. Lee, U.C. Shin, S.W. Kim, B.I. Kim, K.C. Lee et al., Improved
pharmacokinetics following PEGylation and dimerization of a c(RGD-ACH-K) conjugate
used for tumor positron emission tomography imaging. Cancer Biother. Radiopharm. 31(8),
295–301 (2016)
42. Y.K. Lee, J.M. Jeong, L. Hoigebazar, B.Y. Yang, Y.S. Lee, B.C. Lee et al., Nanoparticles
modified by encapsulation of ligands with a long alkyl chain to affect multispecific and
multimodal imaging. J. Nucl. Med. 53(9), 1462–1470 (2012)
43. Y.S. Lee, Y.I. Kim, D.S. Lee, Future perspectives of radionanomedicine using the novel
micelle-encapsulation method for surface modification. Nucl. Med. Mol. Imaging 49(3), 170–
173 (2015)
44. B.Y. Yang, S.H. Moon, S.R. Seelam, M.J. Jeon, Y.S. Lee, D.S. Lee et al., Development of a
multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized
amphiphiles for lymph node imaging. Nanomed. (Lond). 10(12), 1899–1910 (2015)
45. S.H. Moon, B.Y. Yang, Y.J. Kim, M.K. Hong, Y.S. Lee, D.S. Lee et al., Development of a
complementary PET/MR dual-modal imaging probe for targeting prostate-specific membrane
antigen (PSMA). Nanomedicine 12(4), 871–879 (2016)
344
D. S. Lee and Y.-S. Lee