Chapter 18
Polyethylene Glycolation (PEGylation)
and the Similar
Dong Soo Lee and Yun-Sang Lee
Abstract To overcome the adverse effect of hydrophobicity of nanomaterials,
polyethylene glycolation (PEGylation) is popularly used, which were already in
clinical use of peptide or monoclonal antibodies. The same PEGylation is tried to
hydrophilize nanomaterials but the results of this PEGylation differs according to
the size, shape, terminal residues and others. The bodily response to the nanomaterials depend upon immune recognition of the PEG by IgM or innate immune cells.
Mechanism of innate immune response to PEGylated nanomaterials are poorly
understood. Zwitterions such as polybetaines were proposed to replace PEGs for
hydrophilization. The mechanism is being investigated and not yet clearly known.
The method to modify the surface of nanomaterials with PEGs and zwitterions can
also influence final bodily response and thus simple and easy method of encapsulation was developed. The effect of diverse modification of nanomaterials with
PEGs or zwitterions shall be understood with nanomaterials modified with this
encapsulation method.
18.1 Introduction
Hydrophobicity of nanomaterials cause problems in vivo when injected systemically.
The problems are associated with aggregation-proneness of hydrophobic materials
in aqueous plasma and also the addition of corona proteins. Once aggregated,
D. S. Lee (&) Á Y.-S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: dsl@snu.ac.kr
Y.-S. Lee
e-mail: wonza43@snu.ac.kr
D. S. Lee Á Y.-S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
Seoul National University, Seoul 08826, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_18
331
Polyethylene Glycolation (PEGylation)
and the Similar
Dong Soo Lee and Yun-Sang Lee
Abstract To overcome the adverse effect of hydrophobicity of nanomaterials,
polyethylene glycolation (PEGylation) is popularly used, which were already in
clinical use of peptide or monoclonal antibodies. The same PEGylation is tried to
hydrophilize nanomaterials but the results of this PEGylation differs according to
the size, shape, terminal residues and others. The bodily response to the nanomaterials depend upon immune recognition of the PEG by IgM or innate immune cells.
Mechanism of innate immune response to PEGylated nanomaterials are poorly
understood. Zwitterions such as polybetaines were proposed to replace PEGs for
hydrophilization. The mechanism is being investigated and not yet clearly known.
The method to modify the surface of nanomaterials with PEGs and zwitterions can
also influence final bodily response and thus simple and easy method of encapsulation was developed. The effect of diverse modification of nanomaterials with
PEGs or zwitterions shall be understood with nanomaterials modified with this
encapsulation method.
18.1 Introduction
Hydrophobicity of nanomaterials cause problems in vivo when injected systemically.
The problems are associated with aggregation-proneness of hydrophobic materials
in aqueous plasma and also the addition of corona proteins. Once aggregated,
D. S. Lee (&) Á Y.-S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: dsl@snu.ac.kr
Y.-S. Lee
e-mail: wonza43@snu.ac.kr
D. S. Lee Á Y.-S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
Seoul National University, Seoul 08826, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_18
331