References
1. H.C. Kolb, M.G. Finn, K.B. Sharpless, Click chemistry: diverse chemical function from a few
good reactions. Angew. Chem. Int. Ed. Engl. 40(11), 2004–2021 (2001)
2. H.K. He, C. Gao, Click chemistry on nano-surfaces. Curr. Org. Chem. 15(21), 3667–3691
(2011)
3. J.P. Meyer, P. Adumeau, J.S. Lewis, B.M. Zeglis, Click chemistry and radiochemistry: the
first 10 years. Bioconjuga. Chem. 27(12), 2791–2807 (2016)
4. E.Y. Sun, L. Josephson, R. Weissleder, “Clickable” nanoparticles for targeted imaging. Mol.
Imaging 5(2), 122–128 (2006)
5. J.E. Hein, V.V. Fokin, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond:
new reactivity of copper(I) acetylides. Chem. Soc. Rev. 39(4), 1302–1315 (2010)
6. N.J. Agard, J.A. Prescher, C.R. Bertozzi, A strain-promoted [3+2] azide-alkyne cycloaddition
for covalent modification of blomolecules in living systems. J. Am. Chem. Soc. 126(46),
15046–15047 (2004)
7. M.L. Blackman, M. Royzen, J.M. Fox, Tetrazine ligation: fast bioconjugation based on
inverse-electron-demand Diels-Alder reactivity. J. Am. Chem. Soc. 130(41), 13518–13519
(2008)
8. M. Pretze, M. Kuchar, R. Bergmann, J. Steinbach, J. Pietzsch, C. Mamat, An efficient
bioorthogonal strategy using CuAAC click chemistry for radiofluorinations of SNEW
peptides and the role of copper depletion. Chem. Med. Chem. 8(6), 935–945 (2013)
9. H.L. Evans, L. Carroll, E.O. Aboagye, A.C. Spivey, Bioorthogonal chemistry for Ga-68
radiolabelling of DOTA-containing compounds. J. Label. Compd. Radiopharm. 57(4), 291–
297 (2014)
10. K. Kang, J. Park, E. Kim, Tetrazine ligation for chemical proteomics. Proteome. Sci. 15, 15
(2017)
11. B. Dubertret, P. Skourides, D.J. Norris, V. Noireaux, A.H. Brivanlou, A. Libchaber, In vivo
imaging of quantum dots encapsulated in phospholipid micelles. Science 298(5599), 1759–
1762 (2002)
12. Y.K. Lee, J.M. Jeong, L. Hoigebazar, B.Y. Yang, Y.S. Lee, B.C. Lee et al., Nanoparticles
modified by encapsulation of ligands with a long alkyl chain to affect multispecific and
multimodal imaging. J. Nucl. Med. 53(9), 1462–1470 (2012)
13. B.Y. Yang, S.H. Moon, S.R. Seelam, M.J. Jeon, Y.S. Lee, D.S. Lee et al., Development of a
multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized
amphiphiles for lymph node imaging. Nanomed. (Lond.) 10(12), 1899–1910 (2015)
14. S.H. Moon, B.Y. Yang, Y.J. Kim, M.K. Hong, Y.S. Lee, D.S. Lee et al., Development of a
complementary PET/MR dual-modal imaging probe for targeting prostate-specific membrane
antigen (PSMA). Nanomedicine 12(4), 871–879 (2016)
15. H.J. Seo, S.H. Nam, H.J. Im, J.Y. Park, J.Y. Lee, B. Yoo et al., Rapid hepatobiliary excretion
of micelle-encapsulated/radiolabeled upconverting nanoparticles as an integrated form. Sci.
Rep. 5, 15685 (2015)
16. Y. Matsumura, H. Maeda, A new concept for macromolecular therapeutics in
cancer-chemotherapy—mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res. 46(12), 6387–6392 (1986)
17. F. Danhier, To exploit the tumor microenvironment: since the EPR effect fails in the clinic,
what is the future of nanomedicine? J. Control Release 244, 108–121 (2016)
18. H. Maeda, Toward a full understanding of the EPR effect in primary and metastatic tumors as
well as issues related to its heterogeneity. Adv. Drug Deliver. Rev. 91, 3–6 (2015)
19. M.K. Yu, J. Park, S. Jon, Targeting strategies for multifunctional nanoparticles in cancer
imaging and therapy. Theranostics 2(1), 3–44 (2012)
20. G. Gasparini, P.C. Brooks, E. Biganzoli, P.B. Vermeulen, E. Bonoldi, L.Y. Dirix et al.,
Vascular integrin alpha(v)beta(3): a new prognostic indicator in breast cancer. Clin. Cancer
Res. 4(11), 2625–2634 (1998)
12 Click Chemistry for Radionanomedicine Platform
247
1. H.C. Kolb, M.G. Finn, K.B. Sharpless, Click chemistry: diverse chemical function from a few
good reactions. Angew. Chem. Int. Ed. Engl. 40(11), 2004–2021 (2001)
2. H.K. He, C. Gao, Click chemistry on nano-surfaces. Curr. Org. Chem. 15(21), 3667–3691
(2011)
3. J.P. Meyer, P. Adumeau, J.S. Lewis, B.M. Zeglis, Click chemistry and radiochemistry: the
first 10 years. Bioconjuga. Chem. 27(12), 2791–2807 (2016)
4. E.Y. Sun, L. Josephson, R. Weissleder, “Clickable” nanoparticles for targeted imaging. Mol.
Imaging 5(2), 122–128 (2006)
5. J.E. Hein, V.V. Fokin, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond:
new reactivity of copper(I) acetylides. Chem. Soc. Rev. 39(4), 1302–1315 (2010)
6. N.J. Agard, J.A. Prescher, C.R. Bertozzi, A strain-promoted [3+2] azide-alkyne cycloaddition
for covalent modification of blomolecules in living systems. J. Am. Chem. Soc. 126(46),
15046–15047 (2004)
7. M.L. Blackman, M. Royzen, J.M. Fox, Tetrazine ligation: fast bioconjugation based on
inverse-electron-demand Diels-Alder reactivity. J. Am. Chem. Soc. 130(41), 13518–13519
(2008)
8. M. Pretze, M. Kuchar, R. Bergmann, J. Steinbach, J. Pietzsch, C. Mamat, An efficient
bioorthogonal strategy using CuAAC click chemistry for radiofluorinations of SNEW
peptides and the role of copper depletion. Chem. Med. Chem. 8(6), 935–945 (2013)
9. H.L. Evans, L. Carroll, E.O. Aboagye, A.C. Spivey, Bioorthogonal chemistry for Ga-68
radiolabelling of DOTA-containing compounds. J. Label. Compd. Radiopharm. 57(4), 291–
297 (2014)
10. K. Kang, J. Park, E. Kim, Tetrazine ligation for chemical proteomics. Proteome. Sci. 15, 15
(2017)
11. B. Dubertret, P. Skourides, D.J. Norris, V. Noireaux, A.H. Brivanlou, A. Libchaber, In vivo
imaging of quantum dots encapsulated in phospholipid micelles. Science 298(5599), 1759–
1762 (2002)
12. Y.K. Lee, J.M. Jeong, L. Hoigebazar, B.Y. Yang, Y.S. Lee, B.C. Lee et al., Nanoparticles
modified by encapsulation of ligands with a long alkyl chain to affect multispecific and
multimodal imaging. J. Nucl. Med. 53(9), 1462–1470 (2012)
13. B.Y. Yang, S.H. Moon, S.R. Seelam, M.J. Jeon, Y.S. Lee, D.S. Lee et al., Development of a
multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized
amphiphiles for lymph node imaging. Nanomed. (Lond.) 10(12), 1899–1910 (2015)
14. S.H. Moon, B.Y. Yang, Y.J. Kim, M.K. Hong, Y.S. Lee, D.S. Lee et al., Development of a
complementary PET/MR dual-modal imaging probe for targeting prostate-specific membrane
antigen (PSMA). Nanomedicine 12(4), 871–879 (2016)
15. H.J. Seo, S.H. Nam, H.J. Im, J.Y. Park, J.Y. Lee, B. Yoo et al., Rapid hepatobiliary excretion
of micelle-encapsulated/radiolabeled upconverting nanoparticles as an integrated form. Sci.
Rep. 5, 15685 (2015)
16. Y. Matsumura, H. Maeda, A new concept for macromolecular therapeutics in
cancer-chemotherapy—mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res. 46(12), 6387–6392 (1986)
17. F. Danhier, To exploit the tumor microenvironment: since the EPR effect fails in the clinic,
what is the future of nanomedicine? J. Control Release 244, 108–121 (2016)
18. H. Maeda, Toward a full understanding of the EPR effect in primary and metastatic tumors as
well as issues related to its heterogeneity. Adv. Drug Deliver. Rev. 91, 3–6 (2015)
19. M.K. Yu, J. Park, S. Jon, Targeting strategies for multifunctional nanoparticles in cancer
imaging and therapy. Theranostics 2(1), 3–44 (2012)
20. G. Gasparini, P.C. Brooks, E. Biganzoli, P.B. Vermeulen, E. Bonoldi, L.Y. Dirix et al.,
Vascular integrin alpha(v)beta(3): a new prognostic indicator in breast cancer. Clin. Cancer
Res. 4(11), 2625–2634 (1998)
12 Click Chemistry for Radionanomedicine Platform
247