Chapter 12
Click Chemistry for Radionanomedicine
Platform
Yun-Sang Lee, Lingyi Sun and Dexing Zeng
Abstract The emerging radionanomedicine has multifunctional and theranostic
purposes. To fulfill these purposes, the radionanomedicine should achieve efficient
and specific delivery of therapeutic agents by their multifunctionality with very low
amount of nanomaterials used in vivo. Recent researches on radiolabeled
micelle-encapsulated nanomaterials are promising for their efficacy and safety as
one-step surface modification method. This one-step multifunctional approach to
the nanoparticles is important to meet the challenges of manufacturing and is the
basis for making the effective nano-platforms for disease-targeted imaging and
therapy. Based on ‘click chemistry’ concept, great progress have been achieved in
the field of radiochemistry and nanomedicine. Click chemistry can be used for the
surface modification of nanomedicines, such as hydrophilization, target molecule
ligation, therapeutic drug conjugation, and labeling sensor molecules including
fluorescence dyes or radioisotopes. By the conventional step-by-step chemical
modification method of nanomaterials, two or more combination of those modifications can hardly achieve practicability, because of the low yield of each step of
Y.-S. Lee (&)
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: wonza43@snu.ac.kr
Y.-S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology, Seoul National
University, Seoul 08826, Republic of Korea
L. Sun Á D. Zeng (&)
Department of Medicine, University of Pittsburgh School of Medicine,
Pittsburgh, PA 15260, USA
e-mail: zengd@upmc.edu
L. Sun
e-mail: lis85@pitt.edu
D. Zeng
Department of Radiology, University of Pittsburgh School of Medicine,
Pittsburgh, PA 15213, USA
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_12
231
Click Chemistry for Radionanomedicine
Platform
Yun-Sang Lee, Lingyi Sun and Dexing Zeng
Abstract The emerging radionanomedicine has multifunctional and theranostic
purposes. To fulfill these purposes, the radionanomedicine should achieve efficient
and specific delivery of therapeutic agents by their multifunctionality with very low
amount of nanomaterials used in vivo. Recent researches on radiolabeled
micelle-encapsulated nanomaterials are promising for their efficacy and safety as
one-step surface modification method. This one-step multifunctional approach to
the nanoparticles is important to meet the challenges of manufacturing and is the
basis for making the effective nano-platforms for disease-targeted imaging and
therapy. Based on ‘click chemistry’ concept, great progress have been achieved in
the field of radiochemistry and nanomedicine. Click chemistry can be used for the
surface modification of nanomedicines, such as hydrophilization, target molecule
ligation, therapeutic drug conjugation, and labeling sensor molecules including
fluorescence dyes or radioisotopes. By the conventional step-by-step chemical
modification method of nanomaterials, two or more combination of those modifications can hardly achieve practicability, because of the low yield of each step of
Y.-S. Lee (&)
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: wonza43@snu.ac.kr
Y.-S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology, Seoul National
University, Seoul 08826, Republic of Korea
L. Sun Á D. Zeng (&)
Department of Medicine, University of Pittsburgh School of Medicine,
Pittsburgh, PA 15260, USA
e-mail: zengd@upmc.edu
L. Sun
e-mail: lis85@pitt.edu
D. Zeng
Department of Radiology, University of Pittsburgh School of Medicine,
Pittsburgh, PA 15213, USA
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_12
231