make radionanomaterials based on nanoplatform concept. This will make
(1) manufacturing part making precursor chelator or click donor-conjugated
nanomaterials and (2) compounding part labeling radionuclide to the chelators on
the nanomaterials or mixing click recipient-chelator prelabeled with radionuclides,
respectively. In Chap. 13, the authors will emphasize the advantage of click
chemistry which allows very rapid reaction in vitro under ambient condition and
underline the functional integrities of the product and even enabling pretargeted
imaging strategy. The readers will find the core concept of click chemistry overcoming the delicate problem of maintaining integrity of surface-modifying materials bound in various ways. In Chap. 14, the author emphasized bioorthogonal
reaction and finally focused on the F-18 labeling of biomacromolecules and
nanomaterials. Successful report of pretargeting imaging strategy with F-18 was
detailed and the beauty of this approach is that its expandability can be found in this
chapter. Now, we need more practical examples of this reaction.
230
Part IV: Targeted Delivery with Click Chemistry
(1) manufacturing part making precursor chelator or click donor-conjugated
nanomaterials and (2) compounding part labeling radionuclide to the chelators on
the nanomaterials or mixing click recipient-chelator prelabeled with radionuclides,
respectively. In Chap. 13, the authors will emphasize the advantage of click
chemistry which allows very rapid reaction in vitro under ambient condition and
underline the functional integrities of the product and even enabling pretargeted
imaging strategy. The readers will find the core concept of click chemistry overcoming the delicate problem of maintaining integrity of surface-modifying materials bound in various ways. In Chap. 14, the author emphasized bioorthogonal
reaction and finally focused on the F-18 labeling of biomacromolecules and
nanomaterials. Successful report of pretargeting imaging strategy with F-18 was
detailed and the beauty of this approach is that its expandability can be found in this
chapter. Now, we need more practical examples of this reaction.
230
Part IV: Targeted Delivery with Click Chemistry