Table 11.1 Radiolabeling of NPs (modified from [1])
Radiolabeling
Radioisotope
(half-life)
Nanoparticles
Chelator
References
Intrinsic
64
Cu (12.7 h)
CuS
[7]
IO
[8]
Gold
[9]
Ferritin
nanocage
[10]
Porphysomes
[11]
198
Au(2.69 d)
Gold
[12–16]
Gold
nanocages
[17]
153
Sm (46.3 h)
Ln doped NP
[18, 19]
109
Cd (461.4 d)
QD
[4]
111
In (2.8 d)
IO
[20]
18
F (109.8 min)
Ln doped NP
[21, 22]
72
As (12.6 h)
IO
[23]
69
Ge (39.05 h)
IO
[24]
Extrinsic
99m
Tc (6 h)
Gold
Hynic
[25–27]
DTPA
[28]
IO
DTPA
[29]
64
Cu (12.7 h)
QD
DOTA
[30, 31]
Gold
nanoshell
DOTA
[32]
IO
DOTA
[33–35]
Carbon
nanotube
DOTA
[36]
Liposome
DOTA
[37]
111
In (2.8 d)
Carbon
nanotube
DTPA
[38, 39]
DOTA
[40]
Micelle
DTPA
[41]
124
I (4.18 d)
IO
Iodo-bead
[42]
Ln doped NP
Iodo-bead
[43]
188
Re (16.9 h)
IO
[M(CO) 3 (OH 2 ) 3 ]
+
[44, 45]
Liposome
BMEDA
[46]
177
Lu (6.73 d)
Gold
DOTA
[47]
68
Ga (67.7 min)
QD
DOTA
[48]
67
Ga (78.3 h)
Cobalt-ferrite
NOTA
[7, 49]
QD quantum dot, IO iron oxide, Ln lanthanide, BMEDA = N,N-bis(2-mercaptoethyl)-N′,N′diethylethylenediamine
11 Radiolabeling Method: Core/Surface Labeling, Chemical …
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