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targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS Nano 7(10), 9027–9039 (2013)
68. D. Desai, J. Zhang, J. Sandholm, J. Lehtimaki, T. Gronroos, J. Tuomela et al., Lipid
bilayer-gated mesoporous silica nanocarriers for tumor-targeted delivery of zoledronic acid
in Vivo. Mol. Pharm. 14(9), 3218–3227 (2017)
69. D. Chen, C.A. Dougherty, K. Zhu, H. Hong, Theranostic applications of carbon nanomaterials
in cancer: focus on imaging and cargo delivery. J. Control Release 210, 230–245 (2015)
70. K. Yang, L. Feng, H. Hong, W. Cai, Z. Liu, Preparation and functionalization of graphene
nanocomposites for biomedical applications. Nat. Protoc. 8(12), 2392–2403 (2013)
71. M. Xu, J. Zhu, F. Wang, Y. Xiong, Y. Wu, Q. Wang et al., Improved in vitro and in vivo
biocompatibility of graphene oxide through surface modification: poly (acrylic acid)functionalization is superior to PEGylation. ACS Nano 10(3), 3267–3281 (2016)
10 Surface Modification of Radionanomedicine
203
nanoparticles as potential vehicles for anticancer drugs. Adv. Protein Chem. Struct. Biol. 98,
169–221 (2015)
55. E. Yasun, C. Li, I. Barut, D. Janvier, L. Qiu, C. Cui et al., BSA modification to reduce
CTAB induced nonspecificity and cytotoxicity of aptamer-conjugated gold nanorods.
Nanoscale 7(22), 10240–10248 (2015)
56. T.V. Verissimo, N.T. Santos, J.R. Silva, R.B. Azevedo, A.J. Gomes, C.N. Lunardi, In vitro
cytotoxicity and phototoxicity of surface-modified gold nanoparticles associated with neutral
red as a potential drug delivery system in phototherapy. Mater. Sci. Eng. C Mater. Biol.
Appl. 65, 199–204 (2016)
57. S.B. Lee, H.W. Lee, T.D. Singh, Y. Li, S.K. Kim, S.J. Cho et al., Visualization of
macrophage recruitment to inflammation lesions using highly sensitive and stable
radionuclide-embedded gold nanoparticles as a nuclear bio-imaging platform. Theranostics
7(4), 926–934 (2017)
58. H. Heinz, H. Ramezani-Dakhel, Simulations of inorganic-bioorganic interfaces to discover
new materials: insights, comparisons to experiment, challenges, and opportunities. Chem.
Soc. Rev. 45(2), 412–448 (2016)
59. Y. Kapilov-Buchman, E. Lellouche, S. Michaeli, J.P. Lellouche, Unique surface modification of silica nanoparticles with polyethylenimine (PEI) for siRNA delivery using cerium
cation coordination chemistry. Bioconjug. Chem. 26(5), 880–889 (2015)
60. S. Shi, F. Chen, W. Cai, Biomedical applications of functionalized hollow mesoporous silica
nanoparticles: focusing on molecular imaging. Nanomed. (Lond.) 8(12), 2027–2039 (2013)
61. X. Huang, F. Zhang, S. Lee, M. Swierczewska, D.O. Kiesewetter, L. Lang et al., Long-term
multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based
nanoprobes. Biomaterials 33(17), 4370–4378 (2012)
62. F. Chen, H.F. Valdovinos, R. Hernandez, S. Goel, T.E. Barnhart, W. Cai, Intrinsic
radiolabeling of Titanium-45 using mesoporous silica nanoparticles. Acta Pharmacol. Sin.
38(6), 907–913 (2017)
63. P.A. Ellison, F. Chen, S. Goel, T.E. Barnhart, R.J. Nickles, O.T. DeJesus et al., Intrinsic and
stable conjugation of thiolated mesoporous silica nanoparticles with radioarsenic. ACS Appl.
Mater. Interfaces 9(8), 6772–6781 (2017)
64. S. Goel, F. Chen, S. Luan, H.F. Valdovinos, S. Shi, S.A. Graves et al., Engineering
intrinsically zirconium-89 radiolabeled self-destructing mesoporous silica nanostructures for
in vivo biodistribution and tumor targeting studies. Adv. Sci. 3(11), 1600122 (2016)
65. F. Chen, S. Goel, H.F. Valdovinos, H. Luo, R. Hernandez, T.E. Barnhart et al., In vivo
integrity and biological fate of chelator-free zirconium-89-labeled mesoporous silica
nanoparticles. ACS Nano 9(8), 7950–7959 (2015)
66. F. Chen, H. Hong, S. Shi, S. Goel, H.F. Valdovinos, R. Hernandez et al., Engineering of
hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting
efficacy. Sci. Rep. 4, 5080 (2014)
67. F. Chen, H. Hong, Y. Zhang, H.F. Valdovinos, S. Shi, G.S. Kwon et al., In vivo tumor
targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS Nano 7(10), 9027–9039 (2013)
68. D. Desai, J. Zhang, J. Sandholm, J. Lehtimaki, T. Gronroos, J. Tuomela et al., Lipid
bilayer-gated mesoporous silica nanocarriers for tumor-targeted delivery of zoledronic acid
in Vivo. Mol. Pharm. 14(9), 3218–3227 (2017)
69. D. Chen, C.A. Dougherty, K. Zhu, H. Hong, Theranostic applications of carbon nanomaterials
in cancer: focus on imaging and cargo delivery. J. Control Release 210, 230–245 (2015)
70. K. Yang, L. Feng, H. Hong, W. Cai, Z. Liu, Preparation and functionalization of graphene
nanocomposites for biomedical applications. Nat. Protoc. 8(12), 2392–2403 (2013)
71. M. Xu, J. Zhu, F. Wang, Y. Xiong, Y. Wu, Q. Wang et al., Improved in vitro and in vivo
biocompatibility of graphene oxide through surface modification: poly (acrylic acid)functionalization is superior to PEGylation. ACS Nano 10(3), 3267–3281 (2016)
10 Surface Modification of Radionanomedicine
203