23. M. Morishita, Y. Takahashi, M. Nishikawa, K. Sano, K. Kato, T. Yamashita et al.,
Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a
streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after
intravenous injection in mice. J. Pharm. Sci. 104(2), 705–713 (2015)
24. H. Choi, S.C. Jang, M.Y. Yoo, J.Y. Park, N.E. Choi, H.J. Oh et al., Noninvasive imaging of
radiolabeled exosome-mimetic nanovesicle using
99m Tc-HMPAO. Sci. Rep. 5, 15636 (2015)
25. Z. Varga, I. Gyurkó, K. Pálóczi, E.I. Buzás, I. Horváth, N. Hegedűs et al., Radiolabeling of
extracellular vesicles with
99m Tc for quantitative in vivo imaging studies. Cancer Biother.
Radiopharm. 31(5), 168–173 (2016)
26. L. Hu, S.A. Wickline, J.L. Hood, Magnetic resonance imaging of melanoma exosomes in
lymph nodes. Magn. Reson. Med. 74(1), 266–271 (2015)
27. A. Busato, R. Bonafede, P. Bontempi, I. Scambi, L. Schiaffino, D. Benati et al., Magnetic
resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem
cells: a new method to obtain labeled exosomes. Int. J. Nanomedicine 11, 2481 (2016)
28. S.A. Kooijmans, S. Stremersch, K. Braeckmans, S.C. de Smedt, A. Hendrix, M.J. Wood et al.,
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into
extracellular vesicles. J. Control Release. 172(1), 229–238 (2013)
29. R.C. Lai, T.S. Chen, S.K. Lim, Mesenchymal stem cell exosome: a novel stem cell-based
therapy for cardiovascular disease. Regen. Med. 6(4), 481–492 (2011)
30. L. Timmers, S.K. Lim, I.E. Hoefer, F. Arslan, R.C. Lai, A.A. van Oorschot et al., Human
mesenchymal stem cell-conditioned medium improves cardiac function following myocardial
infarction. Stem Cell Res. 6(3), 206–214 (2011)
31. S. Gatti, S. Bruno, M.C. Deregibus, A. Sordi, V. Cantaluppi, C. Tetta et al., Microvesicles
derived
from
human
adult
mesenchymal
stem
cells
protect
against
ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol. Dial. Transplant.
26(5), 1474–1483 (2011)
32. S. Bian, L. Zhang, L. Duan, X. Wang, Y. Min, H. Yu, Extracellular vesicles derived from
human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial
infarction model. J. Mol. Med. Berl. 92(4), 387–397 (2014)
33. L. Kilpinen, U. Impola, L. Sankkila, I. Ritamo, M. Aatonen, S. Kilpinen et al., Extracellular
membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute
kidney injury, a feature that is lost after inflammatory conditioning. J. Extracell. Vesicles 2(1),
21927 (2013)
34. H. Peinado, M. Alečković, S. Lavotshkin, I. Matei, B. Costa-Silva, G. Moreno-Bueno et al.,
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic
phenotype through MET. Nat. Med. 18(6), 883–891 (2012)
35. O.P. Wiklander, J.Z. Nordin, A. O’Loughlin, Y. Gustafsson, G. Corso, I. Mäger et al.,
Extracellular vesicle in vivo biodistribution is determined by cell source, route of
administration and targeting. J. Extracell. Vesicles 4(1), 26316 (2015)
36. K.W. Witwer, E.I. Buzas, L.T. Bemis, A. Bora, C. Lässer, J. Lötvall et al., Standardization of
sample collection, isolation and analysis methods in extracellular vesicle research.
J. Extracell. Vesicles 2(1), 20360 (2013)
37. A.N. Böing, E. Van Der Pol, A.E. Grootemaat, F.A. Coumans, A. Sturk, R. Nieuwland,
Single-step isolation of extracellular vesicles by size-exclusion chromatography. J. Extracell.
Vesicles 3(1), 23430 (2014)
38. J.Z. Nordin, Y. Lee, P. Vader, I. Mäger, H.J. Johansson, W. Heusermann et al., Ultrafiltration
with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles
preserving intact biophysical and functional properties. Nanomedicine 11(4), 879–883 (2015)
39. R. Linares, S. Tan, C. Gounou, N. Arraud, A.R. Brisson, High-speed centrifugation induces
aggregation of extracellular vesicles. J. Extracell. Vesicles 4(1), 29509 (2015)
40. R. van der Meel, M.H. Fens, P. Vader, W.W. van Solinge, O. Eniola-Adefeso, R.M.
Schiffelers, Extracellular vesicles as drug delivery systems: lessons from the liposome field.
J. Control Release. 195, 72–85 (2014)
164
H. Choi and D. S. Lee
Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a
streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after
intravenous injection in mice. J. Pharm. Sci. 104(2), 705–713 (2015)
24. H. Choi, S.C. Jang, M.Y. Yoo, J.Y. Park, N.E. Choi, H.J. Oh et al., Noninvasive imaging of
radiolabeled exosome-mimetic nanovesicle using
99m Tc-HMPAO. Sci. Rep. 5, 15636 (2015)
25. Z. Varga, I. Gyurkó, K. Pálóczi, E.I. Buzás, I. Horváth, N. Hegedűs et al., Radiolabeling of
extracellular vesicles with
99m Tc for quantitative in vivo imaging studies. Cancer Biother.
Radiopharm. 31(5), 168–173 (2016)
26. L. Hu, S.A. Wickline, J.L. Hood, Magnetic resonance imaging of melanoma exosomes in
lymph nodes. Magn. Reson. Med. 74(1), 266–271 (2015)
27. A. Busato, R. Bonafede, P. Bontempi, I. Scambi, L. Schiaffino, D. Benati et al., Magnetic
resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem
cells: a new method to obtain labeled exosomes. Int. J. Nanomedicine 11, 2481 (2016)
28. S.A. Kooijmans, S. Stremersch, K. Braeckmans, S.C. de Smedt, A. Hendrix, M.J. Wood et al.,
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into
extracellular vesicles. J. Control Release. 172(1), 229–238 (2013)
29. R.C. Lai, T.S. Chen, S.K. Lim, Mesenchymal stem cell exosome: a novel stem cell-based
therapy for cardiovascular disease. Regen. Med. 6(4), 481–492 (2011)
30. L. Timmers, S.K. Lim, I.E. Hoefer, F. Arslan, R.C. Lai, A.A. van Oorschot et al., Human
mesenchymal stem cell-conditioned medium improves cardiac function following myocardial
infarction. Stem Cell Res. 6(3), 206–214 (2011)
31. S. Gatti, S. Bruno, M.C. Deregibus, A. Sordi, V. Cantaluppi, C. Tetta et al., Microvesicles
derived
from
human
adult
mesenchymal
stem
cells
protect
against
ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol. Dial. Transplant.
26(5), 1474–1483 (2011)
32. S. Bian, L. Zhang, L. Duan, X. Wang, Y. Min, H. Yu, Extracellular vesicles derived from
human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial
infarction model. J. Mol. Med. Berl. 92(4), 387–397 (2014)
33. L. Kilpinen, U. Impola, L. Sankkila, I. Ritamo, M. Aatonen, S. Kilpinen et al., Extracellular
membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute
kidney injury, a feature that is lost after inflammatory conditioning. J. Extracell. Vesicles 2(1),
21927 (2013)
34. H. Peinado, M. Alečković, S. Lavotshkin, I. Matei, B. Costa-Silva, G. Moreno-Bueno et al.,
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic
phenotype through MET. Nat. Med. 18(6), 883–891 (2012)
35. O.P. Wiklander, J.Z. Nordin, A. O’Loughlin, Y. Gustafsson, G. Corso, I. Mäger et al.,
Extracellular vesicle in vivo biodistribution is determined by cell source, route of
administration and targeting. J. Extracell. Vesicles 4(1), 26316 (2015)
36. K.W. Witwer, E.I. Buzas, L.T. Bemis, A. Bora, C. Lässer, J. Lötvall et al., Standardization of
sample collection, isolation and analysis methods in extracellular vesicle research.
J. Extracell. Vesicles 2(1), 20360 (2013)
37. A.N. Böing, E. Van Der Pol, A.E. Grootemaat, F.A. Coumans, A. Sturk, R. Nieuwland,
Single-step isolation of extracellular vesicles by size-exclusion chromatography. J. Extracell.
Vesicles 3(1), 23430 (2014)
38. J.Z. Nordin, Y. Lee, P. Vader, I. Mäger, H.J. Johansson, W. Heusermann et al., Ultrafiltration
with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles
preserving intact biophysical and functional properties. Nanomedicine 11(4), 879–883 (2015)
39. R. Linares, S. Tan, C. Gounou, N. Arraud, A.R. Brisson, High-speed centrifugation induces
aggregation of extracellular vesicles. J. Extracell. Vesicles 4(1), 29509 (2015)
40. R. van der Meel, M.H. Fens, P. Vader, W.W. van Solinge, O. Eniola-Adefeso, R.M.
Schiffelers, Extracellular vesicles as drug delivery systems: lessons from the liposome field.
J. Control Release. 195, 72–85 (2014)
164
H. Choi and D. S. Lee