4. D. Sun, X. Zhuang, S. Zhang, Z.-B. Deng, W. Grizzle, D. Miller et al., Exosomes are
endogenous nanoparticles that can deliver biological information between cells. Adv. Drug
Deliv. Rev. 65(3), 342–347 (2013)
5. M. Colombo, G. Raposo, C. Thery, Biogenesis, secretion, and intercellular interactions of
exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014)
6. A.K.A. Silva, R. Di Corato, T. Pellegrino, S. Chat, G. Pugliese, N. Luciani et al., Cell-derived
vesicles as a bioplatform for the encapsulation of theranostic nanomaterials. Nanoscale 5(23),
11374–11384 (2013)
7. A.K. Silva, N. Luciani, F. Gazeau, K. Aubertin, S. Bonneau, C. Chauvierre et al., Combining
magnetic nanoparticles with cell derived microvesicles for drug loading and targeting.
Nanomedicine 11(3), 645–655 (2015)
8. A.K. Silva, J. Kolosnjaj-Tabi, S. Bonneau, I. Marangon, N. Boggetto, K. Aubertin et al.,
Magnetic and photoresponsive theranosomes: translating cell-released vesicles into smart
nanovectors for cancer therapy. ACS Nano. 7(6), 4954–4966 (2013)
9. C.P. Lai, O. Mardini, M. Ericsson, S. Prabhakar, C.A. Maguire, J.W. Chen et al., Dynamic
biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS
Nano. 8(1), 483–494 (2014)
10. Y. Takahashi, M. Nishikawa, H. Shinotsuka, Y. Matsui, S. Ohara, T. Imai et al., Visualization
and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after
intravenous injection. J. Biotechnol. 165(2), 77–84 (2013)
11. J.L. Hood, R.S. San, S.A. Wickline, Exosomes released by melanoma cells prepare sentinel
lymph nodes for tumor metastasis. Cancer Res. 71(11), 3792–3801 (2011)
12. S. Ohno, M. Takanashi, K. Sudo, S. Ueda, A. Ishikawa, N. Matsuyama et al., Systemically
injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol.
Ther. 21(1), 185–191 (2013)
13. T. Tian, Y.L. Zhu, F.H. Hu, Y.Y. Wang, N.P. Huang, Z.D. Xiao, Dynamics of exosome
internalization and trafficking. J. Cell. Physiol. 228(7), 1487–1495 (2013)
14. T. Smyth, M. Kullberg, N. Malik, P. Smith-Jones, M.W. Graner, T.J. Anchordoquy,
Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J. Control
Release. 199, 145–155 (2015)
15. T. Tian, Y. Wang, H. Wang, Z. Zhu, Z. Xiao, Visualizing of the cellular uptake and
intracellular trafficking of exosomes by live-cell microscopy. J. Cell. Biochem. 111(2), 488–
496 (2010)
16. K. Laulagnier, H. Vincent-Schneider, S. Hamdi, C. Subra, D. Lankar, M. Record,
Characterization of exosome subpopulations from RBL-2H3 cells using fluorescent lipids.
Blood Cells Mol. Dis. 35(2), 116–121 (2005)
17. D. Sun, X. Zhuang, X. Xiang, Y. Liu, S. Zhang, C. Liu et al., A novel nanoparticle drug
delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in
exosomes. Mol. Ther. 18(9), 1606–1614 (2010)
18. C. Grange, M. Tapparo, S. Bruno, D. Chatterjee, P.J. Quesenberry, C. Tetta et al.,
Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute
kidney injury monitored by optical imaging. Int. J. Mol. Med. 33(5), 1055–1063 (2014)
19. M. Mittelbrunn, C. Gutierrez-Vazquez, C. Villarroya-Beltri, S. Gonzalez, F. Sanchez-Cabo,
M.A. Gonzalez et al., Unidirectional transfer of microRNA-loaded exosomes from T cells to
antigen-presenting cells. Nat. Commun. 2, 282 (2011)
20. A. Suetsugu, K. Honma, S. Saji, H. Moriwaki, T. Ochiya, R.M. Hoffman, Imaging exosome
transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse
models. Adv. Drug Deliv. Rev. 65(3), 383–390 (2013)
21. C.P.-K. Lai, X.O. Breakefield, Role of exosomes/microvesicles in the nervous system and use
in emerging therapies. Front Physiol. 3, 228–242 (2012)
22. C.P. Lai, E.Y. Kim, C.E. Badr, R. Weissleder, T.R. Mempel, B.A. Tannous et al.,
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using
multiplexed reporters. Nat. Commun. 6, 7029 (2015)
8 Endogenous Radionanomedicine: Biodistribution and Imaging
163
endogenous nanoparticles that can deliver biological information between cells. Adv. Drug
Deliv. Rev. 65(3), 342–347 (2013)
5. M. Colombo, G. Raposo, C. Thery, Biogenesis, secretion, and intercellular interactions of
exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014)
6. A.K.A. Silva, R. Di Corato, T. Pellegrino, S. Chat, G. Pugliese, N. Luciani et al., Cell-derived
vesicles as a bioplatform for the encapsulation of theranostic nanomaterials. Nanoscale 5(23),
11374–11384 (2013)
7. A.K. Silva, N. Luciani, F. Gazeau, K. Aubertin, S. Bonneau, C. Chauvierre et al., Combining
magnetic nanoparticles with cell derived microvesicles for drug loading and targeting.
Nanomedicine 11(3), 645–655 (2015)
8. A.K. Silva, J. Kolosnjaj-Tabi, S. Bonneau, I. Marangon, N. Boggetto, K. Aubertin et al.,
Magnetic and photoresponsive theranosomes: translating cell-released vesicles into smart
nanovectors for cancer therapy. ACS Nano. 7(6), 4954–4966 (2013)
9. C.P. Lai, O. Mardini, M. Ericsson, S. Prabhakar, C.A. Maguire, J.W. Chen et al., Dynamic
biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS
Nano. 8(1), 483–494 (2014)
10. Y. Takahashi, M. Nishikawa, H. Shinotsuka, Y. Matsui, S. Ohara, T. Imai et al., Visualization
and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after
intravenous injection. J. Biotechnol. 165(2), 77–84 (2013)
11. J.L. Hood, R.S. San, S.A. Wickline, Exosomes released by melanoma cells prepare sentinel
lymph nodes for tumor metastasis. Cancer Res. 71(11), 3792–3801 (2011)
12. S. Ohno, M. Takanashi, K. Sudo, S. Ueda, A. Ishikawa, N. Matsuyama et al., Systemically
injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol.
Ther. 21(1), 185–191 (2013)
13. T. Tian, Y.L. Zhu, F.H. Hu, Y.Y. Wang, N.P. Huang, Z.D. Xiao, Dynamics of exosome
internalization and trafficking. J. Cell. Physiol. 228(7), 1487–1495 (2013)
14. T. Smyth, M. Kullberg, N. Malik, P. Smith-Jones, M.W. Graner, T.J. Anchordoquy,
Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J. Control
Release. 199, 145–155 (2015)
15. T. Tian, Y. Wang, H. Wang, Z. Zhu, Z. Xiao, Visualizing of the cellular uptake and
intracellular trafficking of exosomes by live-cell microscopy. J. Cell. Biochem. 111(2), 488–
496 (2010)
16. K. Laulagnier, H. Vincent-Schneider, S. Hamdi, C. Subra, D. Lankar, M. Record,
Characterization of exosome subpopulations from RBL-2H3 cells using fluorescent lipids.
Blood Cells Mol. Dis. 35(2), 116–121 (2005)
17. D. Sun, X. Zhuang, X. Xiang, Y. Liu, S. Zhang, C. Liu et al., A novel nanoparticle drug
delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in
exosomes. Mol. Ther. 18(9), 1606–1614 (2010)
18. C. Grange, M. Tapparo, S. Bruno, D. Chatterjee, P.J. Quesenberry, C. Tetta et al.,
Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute
kidney injury monitored by optical imaging. Int. J. Mol. Med. 33(5), 1055–1063 (2014)
19. M. Mittelbrunn, C. Gutierrez-Vazquez, C. Villarroya-Beltri, S. Gonzalez, F. Sanchez-Cabo,
M.A. Gonzalez et al., Unidirectional transfer of microRNA-loaded exosomes from T cells to
antigen-presenting cells. Nat. Commun. 2, 282 (2011)
20. A. Suetsugu, K. Honma, S. Saji, H. Moriwaki, T. Ochiya, R.M. Hoffman, Imaging exosome
transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse
models. Adv. Drug Deliv. Rev. 65(3), 383–390 (2013)
21. C.P.-K. Lai, X.O. Breakefield, Role of exosomes/microvesicles in the nervous system and use
in emerging therapies. Front Physiol. 3, 228–242 (2012)
22. C.P. Lai, E.Y. Kim, C.E. Badr, R. Weissleder, T.R. Mempel, B.A. Tannous et al.,
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using
multiplexed reporters. Nat. Commun. 6, 7029 (2015)
8 Endogenous Radionanomedicine: Biodistribution and Imaging
163