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microscopy for efficient serial femtosecond
crystallography. Arch Biochem Biophys
602:61–68. https://doi.org/10.1016/j.abb.
2016.02.011
33. Stevenson HP, Makhov AM, Calero M,
Edwards AL, Zeldin OB, Mathews II, Lin G,
Barnes CO, Santamaria H, Ross TM, Soltis
SM, Khosla C, Nagarajan V, Conway JF,
Cohen AE, Calero G (2014) Use of transmission electron microscopy to identify nanocrystals of challenging protein targets. Proc Natl
Acad Sci U S A 111(23):8470–8475. https://
doi.org/10.1073/pnas.1400240111
34. Hattne J, Shi D, de la Cruz MJ, Reyes FE,
Gonen T (2016) Modeling truncated pixel
values of faint reflections in MicroED images.
J Appl Crystallogr 49(Pt 3):1029–1034.
https://doi.org/10.1107/
S1600576716007196
35. Hattne J, Martynowycz MW, Penczek PA,
Gonen T (2019) MicroED with the Falcon
III direct electron detector. IUCrJ 6
(Pt 5):921–926. https://doi.org/10.1107/
S2052252519010583
36. Tinti G, Frojdh E, van Genderen E, Gruene T,
Schmitt B, de Winter DAM, Weckhuysen BM,
Abrahams JP (2018) Electron crystallography
with the EIGER detector. IUCrJ 5
(Pt 2):190–199. https://doi.org/10.1107/
S2052252518000945
37. Clabbers MTB, van Genderen E, Wan W, Wiegers EL, Gruene T, Abrahams JP (2017) Protein structure determination by electron
diffraction using a single three-dimensional
nanocrystal. Acta Crystallogr D Struct Biol 73
(Pt 9):738–748. https://doi.org/10.1107/
S2059798317010348
MicroED Sample Preparation for Proteins
297