Koropatnick T, Goodson MS, Heath-Heckman EAC, McFall-Ngai M (2014) Identifying the
cellular mechanisms of symbiont- induced epithelial morphogenesis in the squid-Vibrio association. Biol Bull 226:56–68. https://doi.org/10.1086/BBLv226n1p56
Kueh CSW, Chan KY (1985) Bacteria in bivalve shellfish with special reference to the oyster. J
Appl Bacteriol 59:41–47. https://doi.org/10.1111/j.1365-2672.1985.tb01773.x
Le Roux F, Blokesch M (2018) Eco-evolutionary dynamics linked to horizontal gene transfer in
vibrios. Annu Rev Microbiol 72:89–110. https://doi.org/10.1146/annurev-micro-090817062148
Lee KH, Ruby EG (1992) Detection of the light organ symbiont, Vibrio fischeri, in Hawaiian
seawater by using lux gene probes. Appl Environ Microbiol 58:942–947
Lemire A, Goudenege D, Versigny T, Petton B, Calteau A, Labreuche Y, Le Roux F (2015)
Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters. ISME J
9:1523–1531. https://doi.org/10.1038/ismej.2014.233
Lim SJ, Davis BG, Gill DE, Walton J, Nachman E, Engel AS, Anderson LC, Campbell BJ (2020)
Taxonomic and functional heterogeneity of the gill microbiome in a symbiotic coastal mangrove
lucinid species. ISME J 13:902–920. https://doi.org/10.1038/nmicrobiol.2016.195
Mandel MJ, Dunn AK (2016) Impact and influence of the natural Vibrio-squid symbiosis in
understanding bacterial-animal interactions. Front Microbiol 7:1982. https://doi.org/10.3389/
fmicb.2016.01982
Mandel MJ, Wollenberg MS, Stabb EV, Visick KL, Ruby EG (2009) A single regulatory gene is
sufficient to alter bacterial host range. Nature 458:215–218. https://doi.org/10.1038/
nature07660
Mandel MJ, Schaefer AL, Brennan CA, Heath-Heckman EAC, Deloney-Marino CR, McFall-Ngai
MJ, Ruby EG (2012) Squid-derived chitin oligosaccharides are a chemotactic signal during
colonization by Vibrio fischeri. Appl Environ Microbiol 78:4620–4626. https://doi.org/10.1128/
AEM.00377-12
Mathur J, Waldor MK (2004) The Vibrio cholerae ToxR-regulated porin OmpU confers resistance
to antimicrobial peptides. Infect Immun 72:3577–3583. https://doi.org/10.1128/IAI.72.6.35773583.2004
Mathur J, Davis BM, Waldor MK (2007) Antimicrobial peptides activate the Vibrio cholerae σE
regulon through an OmpU-dependent signalling pathway. Mol Microbiol 63:848–858. https://
doi.org/10.1111/j.1365-2958.2006.05544.x
McDougald D, Kjelleberg S (2006) Adaptive responses of vibrios. In: Thompson FL, Austin B,
Swings J (eds) The biology of vibrios. ASM Press, Washington, DC
McFall-Ngai M, Heath-Heckman EAC, Gillette AA, Peyer SM, Harvie EA (2012) The secret
languages of coevolved symbioses: insights from the Euprymna scolopes-Vibrio fischeri symbiosis. Semin Immunol 24:3–8. https://doi.org/10.1016/j.smim.2011.11.006
Musella M, Wathsala R, Tavella T, Barone M, Palldino G, Biagi E, Brigidi P, Turroni S,
Franzellitti S, Candela M (2020) Tissue-scale microbiota of the Mediterranean mussel (Mytilus
galloprovincialis) and its relationship with the environment. Sci Total Environ 717:137209.
https://doi.org/10.1016/j.scitotenv.2020.137209
Nyholm SV, McFall-Ngai MJ (2003) Dominance of Vibrio fischeri in secreted mucus outside the
light organ of Euprymna scolopes: the first site of symbiont specificity. Appl Environ Microbiol
69:3932–3937. https://doi.org/10.1128/AEM.69.7.3932-3937.2003
Nyholm SV, Stabb EV, Ruby EG, McFall-Ngai MJ (2000) Establishment of an animal-bacterial
association: recruiting symbiotic vibrios from the environment. Proc Natl Acad Sci
97:10231–10235. https://doi.org/10.1073/pnas.97.18.10231
Nyholm SV, Deplancke B, Gaskins HR, Apicella MA, McFall-Ngai MJ (2002) Roles of Vibrio
fischeri and nonsymbiotic bacteria in the dynamics of mucus secretion during symbiont
colonization of the Euprymna scolopes light organ. Appl Environ Microbiol 68:5113–5122.
https://doi.org/10.1128/AEM.68.10.5113-5122.2002
Petersen JM, Kemper A, Gruber-Vodicka H, Cardini U, van der Geest M, Kleiner M, Bulgheresi S,
Mußmann M, Herbold C, Seah BK, Antony CP, Liu D, Belitz A, Weber M (2016)
524
A. Lasa and J. L. Romalde
cellular mechanisms of symbiont- induced epithelial morphogenesis in the squid-Vibrio association. Biol Bull 226:56–68. https://doi.org/10.1086/BBLv226n1p56
Kueh CSW, Chan KY (1985) Bacteria in bivalve shellfish with special reference to the oyster. J
Appl Bacteriol 59:41–47. https://doi.org/10.1111/j.1365-2672.1985.tb01773.x
Le Roux F, Blokesch M (2018) Eco-evolutionary dynamics linked to horizontal gene transfer in
vibrios. Annu Rev Microbiol 72:89–110. https://doi.org/10.1146/annurev-micro-090817062148
Lee KH, Ruby EG (1992) Detection of the light organ symbiont, Vibrio fischeri, in Hawaiian
seawater by using lux gene probes. Appl Environ Microbiol 58:942–947
Lemire A, Goudenege D, Versigny T, Petton B, Calteau A, Labreuche Y, Le Roux F (2015)
Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters. ISME J
9:1523–1531. https://doi.org/10.1038/ismej.2014.233
Lim SJ, Davis BG, Gill DE, Walton J, Nachman E, Engel AS, Anderson LC, Campbell BJ (2020)
Taxonomic and functional heterogeneity of the gill microbiome in a symbiotic coastal mangrove
lucinid species. ISME J 13:902–920. https://doi.org/10.1038/nmicrobiol.2016.195
Mandel MJ, Dunn AK (2016) Impact and influence of the natural Vibrio-squid symbiosis in
understanding bacterial-animal interactions. Front Microbiol 7:1982. https://doi.org/10.3389/
fmicb.2016.01982
Mandel MJ, Wollenberg MS, Stabb EV, Visick KL, Ruby EG (2009) A single regulatory gene is
sufficient to alter bacterial host range. Nature 458:215–218. https://doi.org/10.1038/
nature07660
Mandel MJ, Schaefer AL, Brennan CA, Heath-Heckman EAC, Deloney-Marino CR, McFall-Ngai
MJ, Ruby EG (2012) Squid-derived chitin oligosaccharides are a chemotactic signal during
colonization by Vibrio fischeri. Appl Environ Microbiol 78:4620–4626. https://doi.org/10.1128/
AEM.00377-12
Mathur J, Waldor MK (2004) The Vibrio cholerae ToxR-regulated porin OmpU confers resistance
to antimicrobial peptides. Infect Immun 72:3577–3583. https://doi.org/10.1128/IAI.72.6.35773583.2004
Mathur J, Davis BM, Waldor MK (2007) Antimicrobial peptides activate the Vibrio cholerae σE
regulon through an OmpU-dependent signalling pathway. Mol Microbiol 63:848–858. https://
doi.org/10.1111/j.1365-2958.2006.05544.x
McDougald D, Kjelleberg S (2006) Adaptive responses of vibrios. In: Thompson FL, Austin B,
Swings J (eds) The biology of vibrios. ASM Press, Washington, DC
McFall-Ngai M, Heath-Heckman EAC, Gillette AA, Peyer SM, Harvie EA (2012) The secret
languages of coevolved symbioses: insights from the Euprymna scolopes-Vibrio fischeri symbiosis. Semin Immunol 24:3–8. https://doi.org/10.1016/j.smim.2011.11.006
Musella M, Wathsala R, Tavella T, Barone M, Palldino G, Biagi E, Brigidi P, Turroni S,
Franzellitti S, Candela M (2020) Tissue-scale microbiota of the Mediterranean mussel (Mytilus
galloprovincialis) and its relationship with the environment. Sci Total Environ 717:137209.
https://doi.org/10.1016/j.scitotenv.2020.137209
Nyholm SV, McFall-Ngai MJ (2003) Dominance of Vibrio fischeri in secreted mucus outside the
light organ of Euprymna scolopes: the first site of symbiont specificity. Appl Environ Microbiol
69:3932–3937. https://doi.org/10.1128/AEM.69.7.3932-3937.2003
Nyholm SV, Stabb EV, Ruby EG, McFall-Ngai MJ (2000) Establishment of an animal-bacterial
association: recruiting symbiotic vibrios from the environment. Proc Natl Acad Sci
97:10231–10235. https://doi.org/10.1073/pnas.97.18.10231
Nyholm SV, Deplancke B, Gaskins HR, Apicella MA, McFall-Ngai MJ (2002) Roles of Vibrio
fischeri and nonsymbiotic bacteria in the dynamics of mucus secretion during symbiont
colonization of the Euprymna scolopes light organ. Appl Environ Microbiol 68:5113–5122.
https://doi.org/10.1128/AEM.68.10.5113-5122.2002
Petersen JM, Kemper A, Gruber-Vodicka H, Cardini U, van der Geest M, Kleiner M, Bulgheresi S,
Mußmann M, Herbold C, Seah BK, Antony CP, Liu D, Belitz A, Weber M (2016)
524
A. Lasa and J. L. Romalde