prime numbers (see [15]). We have only 1 proteins with 11 chains
and in contrast 30 proteins with 12 chains because 12 could be
written 12 ¼ 2 Â 6 ¼ 3 Â 4 ¼ 3 Â 2 Â 2; this means a cyclic protein
with 12 chains or a dimer of 6 chains or a trimer of 4 chains and so
one.
Interestingly if we look carefully at interfaces between chains in
the data set that is for the Hot Spot Network, we find that 241 proteins have a single connected component (that is all existing interfaces between chains are connected by links between hot spots (see
Fig. 14 to see this property of single connected component for the
Cholera Toxin), 117 proteins with 2 connected components,
81 proteins with 3 connected components, 62 proteins with
4 connected components, and so on (see Fig. 9). In this study, we
Fig. 8 The different stoichiometries in the Data Set
Fig. 9 The number of connected components for HSN
122
Claire Lesieur and Laurent Vuillon
and in contrast 30 proteins with 12 chains because 12 could be
written 12 ¼ 2 Â 6 ¼ 3 Â 4 ¼ 3 Â 2 Â 2; this means a cyclic protein
with 12 chains or a dimer of 6 chains or a trimer of 4 chains and so
one.
Interestingly if we look carefully at interfaces between chains in
the data set that is for the Hot Spot Network, we find that 241 proteins have a single connected component (that is all existing interfaces between chains are connected by links between hot spots (see
Fig. 14 to see this property of single connected component for the
Cholera Toxin), 117 proteins with 2 connected components,
81 proteins with 3 connected components, 62 proteins with
4 connected components, and so on (see Fig. 9). In this study, we
Fig. 8 The different stoichiometries in the Data Set
Fig. 9 The number of connected components for HSN
122
Claire Lesieur and Laurent Vuillon