39
Table 3.2 Aspergillus spp. with their associated genes and siderophoric activity
Aspergillus
spp.
Associated genes
Siderophore activity
A. nidulans AN6238
Siderophore iron transporter, putative
sidC
Ferricrocin synthetase (nonribosomal peptide
siderophore synthase)
sidD
Putative siderophore synthetase
AN7801
Putative siderophore-degrading esterase
sidF
Siderophore biosynthesis acetylase AceI, putative
AN6239
Siderophore biosynthesis lipase/esterase, putative
sidL
Siderophor Biosynthesis protein, putative
mirB
Siderophore iron transporter MirB
mirA
Siderophore iron transporter mirA
mirC
Siderophore iron transporter mirC
A. fumigatus sidD
Fusarinine C is involved in siderophore production
and is known as extracellular nonribosomal peptide
synthetase (NRPS)
sreA
GATA transcription factor that represses genes in
siderophore
sidL
Siderophore biosynthetic pathway. GNAT-type
acetyltransferase
sidF
Extracellular hydroxyornithine transacylase involved
in siderophore biosynthesis
sidA
L-Ornithine N5-oxygenase helps in biosynthesis of
siderophore and iron starvation
zrfB
Zinc transporter that helps in heme biosynthesis and in
the production of triacetylfusarinine C siderophore
Afu8g01310
Helps in siderophore transport
sidJ
Siderophore biosynthesis lipase/esterase
sidC
Putative NRPS which is required for ferricrocin
siderophore biosynthesis
acuM
Putative genes for extracellular siderophore
production
mirB
Putative siderophore SrbA-regulated during hypoxia
involved in iron transport
mirC
Putative siderophore transporter
Afu7g04730, sit1
Putative siderophore transporter
mirD
Putative siderophore transporter
hapX
bZIP transcription factor involved in transcriptional
activation of the siderophore system
(continued)
3 Association of Fungal Siderophores in Human Diseases: Roles and Treatments