185
Pendrak ML, Chao MP, Yan SS et al (2004) Heme oxygenase in Candida albicans is regulated
by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha
biliverdin. J Biol Chem 279(5):3426–3433
Philpott CC, Protchenko O (2008) Response to iron deprivation in Saccharomyces cerevisiae.
Eukaryot Cell 7(1):20–27
Philpott CC, Protchenko O, Kim YW et al (2002) The response to iron deprivation in Saccharomyces
cerevisiae: expression of siderophore-based systems of iron uptake. Biochem Soc Trans
30(4):698–702
Ramanan N, Wang Y (2000) A high-affinity iron permease essential for Candida albicans virulence. Science 288(5468):1062–1064
Renshaw JC, Robson GD, Trinci APJ et al (2002) Fungal siderophores: structures, functions and
applications. Mycol Res 106(10):1123–1142
Saikia S, Oliveira D, Hu G et al (2014) Role of ferric reductases in iron acquisition and virulence
in the fungal pathogen Cryptococcus neoformans. Infect Immun 82(2):839–850
Santos R, Buisson N, Knight S et al (2003) Haemin uptake and use as an iron source by Candida
albicans: role of CaHMX1-encoded haem oxygenase. Microbiology 149(pt 3):579–588
Schrettl M, Winkelmann G, Haas H (2004) Ferrichrome in Schizosaccharomyces pombe —an iron
transport and iron storage compound. Biometals 17(6):647–654
Tamayo E, Gómez-Gallego T, Azcón-Aguilar C et al (2014) Genome-wide analysis of copper,
iron and zinc transporters in the arbuscular mycorrhizal fungus Rhizophagus irregularis. Front
Plant Sci 5:547
Tangen KL, Jung WH, Sham AP et al (2007) The iron- and cAMP-regulated gene SIT1 influences
ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans.
Microbiology 153(Pt1):29–41
Van Ho A, Ward DM, Kaplan J (2002) Transition metal transport in yeast. Annu Rev Microbiol
56:237–261
Weissman Z, Kornitzer D (2004) A family of Candida cell surface haem-binding proteins involved
in haemin and haemoglobin-iron utilization. Mol Microbiol 53(4):1209–1220
Weissman Z, Shemer R, Kornitzer D (2002) Deletion of the copper transporter CaCCC2 reveals
two distinct pathways for iron acquisition in Candida albicans. Mol Microbiol 44(6):1551–1560
Wencewicz TA, Möllmann U, Long TE et al (2009) Is drug release necessary for antimicrobial
activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally
occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic
conjugates. Biometals 22(4):633–648
Yun CW, Tiedeman JS, Moore RE et al (2000) Siderophore-iron uptake in Saccharomyces cerevisiae. J Biol Chem 275(21):16354–16359
Yun CW, Bauler M, Moore RE et al (2001) The role of the FRE family of plasma membrane
reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. J Biol Chem
276(13):10218–10223
11 Siderophores in Antifungal Drug Discovery: A Computational Approach
Pendrak ML, Chao MP, Yan SS et al (2004) Heme oxygenase in Candida albicans is regulated
by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha
biliverdin. J Biol Chem 279(5):3426–3433
Philpott CC, Protchenko O (2008) Response to iron deprivation in Saccharomyces cerevisiae.
Eukaryot Cell 7(1):20–27
Philpott CC, Protchenko O, Kim YW et al (2002) The response to iron deprivation in Saccharomyces
cerevisiae: expression of siderophore-based systems of iron uptake. Biochem Soc Trans
30(4):698–702
Ramanan N, Wang Y (2000) A high-affinity iron permease essential for Candida albicans virulence. Science 288(5468):1062–1064
Renshaw JC, Robson GD, Trinci APJ et al (2002) Fungal siderophores: structures, functions and
applications. Mycol Res 106(10):1123–1142
Saikia S, Oliveira D, Hu G et al (2014) Role of ferric reductases in iron acquisition and virulence
in the fungal pathogen Cryptococcus neoformans. Infect Immun 82(2):839–850
Santos R, Buisson N, Knight S et al (2003) Haemin uptake and use as an iron source by Candida
albicans: role of CaHMX1-encoded haem oxygenase. Microbiology 149(pt 3):579–588
Schrettl M, Winkelmann G, Haas H (2004) Ferrichrome in Schizosaccharomyces pombe —an iron
transport and iron storage compound. Biometals 17(6):647–654
Tamayo E, Gómez-Gallego T, Azcón-Aguilar C et al (2014) Genome-wide analysis of copper,
iron and zinc transporters in the arbuscular mycorrhizal fungus Rhizophagus irregularis. Front
Plant Sci 5:547
Tangen KL, Jung WH, Sham AP et al (2007) The iron- and cAMP-regulated gene SIT1 influences
ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans.
Microbiology 153(Pt1):29–41
Van Ho A, Ward DM, Kaplan J (2002) Transition metal transport in yeast. Annu Rev Microbiol
56:237–261
Weissman Z, Kornitzer D (2004) A family of Candida cell surface haem-binding proteins involved
in haemin and haemoglobin-iron utilization. Mol Microbiol 53(4):1209–1220
Weissman Z, Shemer R, Kornitzer D (2002) Deletion of the copper transporter CaCCC2 reveals
two distinct pathways for iron acquisition in Candida albicans. Mol Microbiol 44(6):1551–1560
Wencewicz TA, Möllmann U, Long TE et al (2009) Is drug release necessary for antimicrobial
activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally
occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic
conjugates. Biometals 22(4):633–648
Yun CW, Tiedeman JS, Moore RE et al (2000) Siderophore-iron uptake in Saccharomyces cerevisiae. J Biol Chem 275(21):16354–16359
Yun CW, Bauler M, Moore RE et al (2001) The role of the FRE family of plasma membrane
reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. J Biol Chem
276(13):10218–10223
11 Siderophores in Antifungal Drug Discovery: A Computational Approach