183
References
Ahmed E, Holmström SJ (2014) Siderophores in environmental research: roles and applications.
Microb Biotechnol 7(3):196–208
Almeida RS, Brunke S, Albrecht A et al (2008) The hyphal-associated adhesin and invasion Als3
of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog 4(11):e1000217
Almeida RS, Wilson D, Hube B (2009) Candida albicans iron acquisition within the host. FEMS
Yeast Res 9(7):1000–1012
Bairwa G, Hee Jung W, Kronstad JW (2017) Iron acquisition in fungal pathogens of humans.
Metallomics 9(3):215–227
Balhara M, Chaudhary R, Ruhil S et al (2016) Siderophores; iron scavengers: the novel & promising
targets for pathogen specific antifungal therapy. Expert Opin Ther Targets 20(12):1477–1489
Bernier G, Girijavallabhan V, Murray A et al (2005) Desketoneoenactin-siderophore conjugates
for Candida: evidence of iron transport-dependent species selectivity. Antimicrob Agents
Chemother 49(1):241–248
Blatzer M, Schrettl M, Sarg B et al (2011) SidL, an Aspergillus fumigatus transacetylase involved
in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl Environ Microbiol
77(14):4959–4966
Bushley KE, Ripoll DR, Turgeon BG (2008) Module evolution and substrate specificity of fungal
nonribosomal peptide synthetases involved in siderophore biosynthesis. BMC Evol Biol 8:328
Cadieux B, Lian T, Hu G et al (2013) The Mannoprotein Cig1 supports iron acquisition from
heme and virulence in the pathogenic fungus Cryptococcus neoformans. J Infect Dis
207(8):1339–1347
Campoy S, Adrio JL (2017) Antifungals. Biochem Pharmacol 133:86–96
Cdc.gov (2017) Types of fungal diseases | fungal diseases | CDC. Available at: https://www.cdc.
gov/fungal/diseases/index.html. Accessed 17 Nov 2018
Cdc.gov (2019a) Antifungal resistance | fungal diseases | CDC. Available at: https://www.cdc.gov/
fungal/antifungal-resistance.html. Accessed 17 Nov 2018
Cdc.gov (2019b) Outbreaks and investigations | fungal diseases | CDC. Available at: https://www.
cdc.gov/fungal/outbreaks/index.html. Accessed 17 Nov 2018
Comensoli L, Bindschedler S, Junier P et al (2017) Iron and fungal physiology: a review of biotechnological opportunities. In: Sariaslani S, Gadd GM (eds) Advances in applied microbiology, vol 98. Elsevier, pp 31–60
Doctor Fungus (2019) Antifungal drug interactions – doctor fungus. Available at: https://drfungus.
org/knowledge-base/antifungal-drug-interactions/. Accessed 17 Nov 2018
Eck R, Hundt S, Härtl A et al (1999) A multicopper oxidase gene from Candida albicans: cloning,
characterization and disruption. Microbiology 145(9):2415–2422
Eichhorn H, Lessing F, Winterberg B et al (2006) A ferroxidation/permeation iron uptake system
is required for virulence in Ustilago maydis. Plant Cell 18(11):3332–3345
Foster LA (2002) Utilization and cell-surface binding of hemin by Histoplasma capsulatum. Can
J Microbiol 48(5):437–442
Fourie R, Kuloyo OO, Mochochoko BM et al (2018) Iron at the centre of Candida albicans interactions. Front Cell Infect Microbiol 8:185
Garnerin T, Dassonville-Klimpt A, Sonnet P (2017) Fungal Hydroxamate Siderophores: biosynthesis, chemical synthesis and potential medical applications. In: Méndez-Vilas A (ed)
Antimicrobial research: novel bioknowledge and educational programs, 6th edn. Formatex
Research Center, pp 477–488
Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake:the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62(4):316–330
Haas H (2014) Fungal siderophore metabolism with a focus on Aspergillus fumigatus. Nat Prod
Rep 31(10):1266–1276
Haas H, Eisendle M, Turgeon BG (2008) Siderophores in fungal physiology and virulence. Annu
Rev Phytopathol 46:149–187
11 Siderophores in Antifungal Drug Discovery: A Computational Approach
References
Ahmed E, Holmström SJ (2014) Siderophores in environmental research: roles and applications.
Microb Biotechnol 7(3):196–208
Almeida RS, Brunke S, Albrecht A et al (2008) The hyphal-associated adhesin and invasion Als3
of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog 4(11):e1000217
Almeida RS, Wilson D, Hube B (2009) Candida albicans iron acquisition within the host. FEMS
Yeast Res 9(7):1000–1012
Bairwa G, Hee Jung W, Kronstad JW (2017) Iron acquisition in fungal pathogens of humans.
Metallomics 9(3):215–227
Balhara M, Chaudhary R, Ruhil S et al (2016) Siderophores; iron scavengers: the novel & promising
targets for pathogen specific antifungal therapy. Expert Opin Ther Targets 20(12):1477–1489
Bernier G, Girijavallabhan V, Murray A et al (2005) Desketoneoenactin-siderophore conjugates
for Candida: evidence of iron transport-dependent species selectivity. Antimicrob Agents
Chemother 49(1):241–248
Blatzer M, Schrettl M, Sarg B et al (2011) SidL, an Aspergillus fumigatus transacetylase involved
in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl Environ Microbiol
77(14):4959–4966
Bushley KE, Ripoll DR, Turgeon BG (2008) Module evolution and substrate specificity of fungal
nonribosomal peptide synthetases involved in siderophore biosynthesis. BMC Evol Biol 8:328
Cadieux B, Lian T, Hu G et al (2013) The Mannoprotein Cig1 supports iron acquisition from
heme and virulence in the pathogenic fungus Cryptococcus neoformans. J Infect Dis
207(8):1339–1347
Campoy S, Adrio JL (2017) Antifungals. Biochem Pharmacol 133:86–96
Cdc.gov (2017) Types of fungal diseases | fungal diseases | CDC. Available at: https://www.cdc.
gov/fungal/diseases/index.html. Accessed 17 Nov 2018
Cdc.gov (2019a) Antifungal resistance | fungal diseases | CDC. Available at: https://www.cdc.gov/
fungal/antifungal-resistance.html. Accessed 17 Nov 2018
Cdc.gov (2019b) Outbreaks and investigations | fungal diseases | CDC. Available at: https://www.
cdc.gov/fungal/outbreaks/index.html. Accessed 17 Nov 2018
Comensoli L, Bindschedler S, Junier P et al (2017) Iron and fungal physiology: a review of biotechnological opportunities. In: Sariaslani S, Gadd GM (eds) Advances in applied microbiology, vol 98. Elsevier, pp 31–60
Doctor Fungus (2019) Antifungal drug interactions – doctor fungus. Available at: https://drfungus.
org/knowledge-base/antifungal-drug-interactions/. Accessed 17 Nov 2018
Eck R, Hundt S, Härtl A et al (1999) A multicopper oxidase gene from Candida albicans: cloning,
characterization and disruption. Microbiology 145(9):2415–2422
Eichhorn H, Lessing F, Winterberg B et al (2006) A ferroxidation/permeation iron uptake system
is required for virulence in Ustilago maydis. Plant Cell 18(11):3332–3345
Foster LA (2002) Utilization and cell-surface binding of hemin by Histoplasma capsulatum. Can
J Microbiol 48(5):437–442
Fourie R, Kuloyo OO, Mochochoko BM et al (2018) Iron at the centre of Candida albicans interactions. Front Cell Infect Microbiol 8:185
Garnerin T, Dassonville-Klimpt A, Sonnet P (2017) Fungal Hydroxamate Siderophores: biosynthesis, chemical synthesis and potential medical applications. In: Méndez-Vilas A (ed)
Antimicrobial research: novel bioknowledge and educational programs, 6th edn. Formatex
Research Center, pp 477–488
Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake:the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62(4):316–330
Haas H (2014) Fungal siderophore metabolism with a focus on Aspergillus fumigatus. Nat Prod
Rep 31(10):1266–1276
Haas H, Eisendle M, Turgeon BG (2008) Siderophores in fungal physiology and virulence. Annu
Rev Phytopathol 46:149–187
11 Siderophores in Antifungal Drug Discovery: A Computational Approach