48
36. Mason, B. N., Starchenko, A., Williams, R. M., Bonassar, L. J., & Reinhart-King, C. A. (2013).
Tuning three-dimensional collagen matrix stiffness independently of collagen concentration
modulates endothelial cell behavior. Acta Biomaterialia, 9, 4635–4644.
37. Matsumoto, T., Yung, Y. C., Fischbach, C., Kong, H. J., Nakaoka, R., & Mooney, D. J. (2007).
Mechanical strain regulates endothelial cell patterning in vitro. Tissue Engineering, 13,
207–217.
38. Munevar, S., Wang, Y., & Dembo, M. (2001). Traction force microscopy of migrating normal
and H-ras transformed 3T3 fibroblasts. Biophysical Journal, 80, 1744–1757.
39. Ng, C. P., Helm, C.-L. E., & Swartz, M. A. (2004). Interstitial flow differentially stimulates
blood and lymphatic endothelial cell morphogenesis in vitro. Microvascular Research, 68,
258–264.
40. Nicoli, S., Standley, C., Walker, P., Hurlstone, A., Fogarty, K. E., & Lawson, N. D. (2010).
MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis.
Nature, 464, 1196–1200.
41. Pelham Jr., R. J., & Yl, W. (1997). Cell locomotion and focal adhesions are regulated by substrate flexibility. Proceedings of the National Academy of Sciences of the United States of
America, 94, 13661–13665.
42. Reinhart-King, C. A., Dembo, M., & Hammer, D. A. (2003). Endothelial cell traction forces
on RGD-derivatized polyacrylamide substrata. Langmuir, 19, 1573–1579.
43. Reinhart-King, C. A., Dembo, M., & Hammer, D. A. (2008). Cell-cell mechanical communication through compliant substrates. Biophysical Journal, 95, 6044–6051.
44. Resnick, N., Yahav, H., Shay-Salit, A., Shushy, M., Schubert, S., Zilberman, L. C. M., et al.
(2003). Fluid shear stress and the vascular endothelium: For better and for worse. Progress in
Biophysics and Molecular Biology, 81, 177–199.
45. Rosenfeld, D., Landau, S., Shandalov, Y., Raindel, N., Freiman, A., Shor, E., et al. (2016).
Morphogenesis of 3D vascular networks is regulated by tensile forces. Proceedings of the
National Academy of Sciences of the United States of America, 113, 3215–3220.
46. Rotenberg, M. Y., Ruvinov, E., Armoza, A., & Cohen, S. (2012). A multi-shear perfusion bioreactor for investigating shear stress effects in endothelial cell constructs. Lab on a Chip, 12,
2696–2703.
47. Santos, L., Fuhrmann, G., Juenet, M., Amdursky, N., Horejs, C.-M., Campagnolo, P., et al.
(2015). Extracellular stiffness modulates the expression of functional proteins and growth factors in endothelial cells. Advanced Healthcare Materials, 4(14), 2056–2063.
48. Shamloo, A., & Heilshorn, S. C. (2010). Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients. Lab on a Chip, 10, 3061–3068.
49. Steward Jr., R., Tambe, D., Hardin, C. C., Krishnan, R., & Fredberg, J. J. (2015). Fluid shear,
intercellular stress, and endothelial cell alignment. American Journal of Physiology. Cell
Physiology, 308, C657–C664.
50. Sun, J., Jamilpour, N., Wang, F.-Y., & Wong, P. K. (2014). Geometric control of capillary
architecture via cell-matrix mechanical interactions. Biomaterials, 35, 3273–3280.
51. Ueda, A., Koga, M., Ikeda, M., Kudo, S., & Tanishita, K. (2004). Effect of shear stress on
microvessel network formation of endothelial cells with in vitro three-dimensional model.
American Journal of Physiology. Heart and Circulatory Physiology, 287, H994–H1002.
52. Underwood, C. J., Edgar, L. T., Hoying, J. B., & Weiss, J. A. (2014). Cell-generated traction
forces and the resulting matrix deformation modulate microvascular alignment and growth
during angiogenesis. American Journal of Physiology. Heart and Circulatory Physiology, 307,
H152–H164.
53. Vailhé, B., Ronot, X., Tracqui, P., Usson, Y., & Tranqui, L. (1997). In vitro angiogenesis is
modulated by the mechanical properties of fibrin gels and is related to αvβ3 integrin localization. In Vitro Cellular & Developmental Biology – Animal, 33, 763–773.
54. van der Schaft, D. W. J., van Spreeuwel, A. C. C., van Assen, H. C., & Baaijens, F. P. T. (2011).
Mechanoregulation of vascularization in aligned tissue-engineered muscle: A role for vascular
endothelial growth factor. Tissue Engineering. Part A, 17, 2857–2865.
B. Zohar et al.
36. Mason, B. N., Starchenko, A., Williams, R. M., Bonassar, L. J., & Reinhart-King, C. A. (2013).
Tuning three-dimensional collagen matrix stiffness independently of collagen concentration
modulates endothelial cell behavior. Acta Biomaterialia, 9, 4635–4644.
37. Matsumoto, T., Yung, Y. C., Fischbach, C., Kong, H. J., Nakaoka, R., & Mooney, D. J. (2007).
Mechanical strain regulates endothelial cell patterning in vitro. Tissue Engineering, 13,
207–217.
38. Munevar, S., Wang, Y., & Dembo, M. (2001). Traction force microscopy of migrating normal
and H-ras transformed 3T3 fibroblasts. Biophysical Journal, 80, 1744–1757.
39. Ng, C. P., Helm, C.-L. E., & Swartz, M. A. (2004). Interstitial flow differentially stimulates
blood and lymphatic endothelial cell morphogenesis in vitro. Microvascular Research, 68,
258–264.
40. Nicoli, S., Standley, C., Walker, P., Hurlstone, A., Fogarty, K. E., & Lawson, N. D. (2010).
MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis.
Nature, 464, 1196–1200.
41. Pelham Jr., R. J., & Yl, W. (1997). Cell locomotion and focal adhesions are regulated by substrate flexibility. Proceedings of the National Academy of Sciences of the United States of
America, 94, 13661–13665.
42. Reinhart-King, C. A., Dembo, M., & Hammer, D. A. (2003). Endothelial cell traction forces
on RGD-derivatized polyacrylamide substrata. Langmuir, 19, 1573–1579.
43. Reinhart-King, C. A., Dembo, M., & Hammer, D. A. (2008). Cell-cell mechanical communication through compliant substrates. Biophysical Journal, 95, 6044–6051.
44. Resnick, N., Yahav, H., Shay-Salit, A., Shushy, M., Schubert, S., Zilberman, L. C. M., et al.
(2003). Fluid shear stress and the vascular endothelium: For better and for worse. Progress in
Biophysics and Molecular Biology, 81, 177–199.
45. Rosenfeld, D., Landau, S., Shandalov, Y., Raindel, N., Freiman, A., Shor, E., et al. (2016).
Morphogenesis of 3D vascular networks is regulated by tensile forces. Proceedings of the
National Academy of Sciences of the United States of America, 113, 3215–3220.
46. Rotenberg, M. Y., Ruvinov, E., Armoza, A., & Cohen, S. (2012). A multi-shear perfusion bioreactor for investigating shear stress effects in endothelial cell constructs. Lab on a Chip, 12,
2696–2703.
47. Santos, L., Fuhrmann, G., Juenet, M., Amdursky, N., Horejs, C.-M., Campagnolo, P., et al.
(2015). Extracellular stiffness modulates the expression of functional proteins and growth factors in endothelial cells. Advanced Healthcare Materials, 4(14), 2056–2063.
48. Shamloo, A., & Heilshorn, S. C. (2010). Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients. Lab on a Chip, 10, 3061–3068.
49. Steward Jr., R., Tambe, D., Hardin, C. C., Krishnan, R., & Fredberg, J. J. (2015). Fluid shear,
intercellular stress, and endothelial cell alignment. American Journal of Physiology. Cell
Physiology, 308, C657–C664.
50. Sun, J., Jamilpour, N., Wang, F.-Y., & Wong, P. K. (2014). Geometric control of capillary
architecture via cell-matrix mechanical interactions. Biomaterials, 35, 3273–3280.
51. Ueda, A., Koga, M., Ikeda, M., Kudo, S., & Tanishita, K. (2004). Effect of shear stress on
microvessel network formation of endothelial cells with in vitro three-dimensional model.
American Journal of Physiology. Heart and Circulatory Physiology, 287, H994–H1002.
52. Underwood, C. J., Edgar, L. T., Hoying, J. B., & Weiss, J. A. (2014). Cell-generated traction
forces and the resulting matrix deformation modulate microvascular alignment and growth
during angiogenesis. American Journal of Physiology. Heart and Circulatory Physiology, 307,
H152–H164.
53. Vailhé, B., Ronot, X., Tracqui, P., Usson, Y., & Tranqui, L. (1997). In vitro angiogenesis is
modulated by the mechanical properties of fibrin gels and is related to αvβ3 integrin localization. In Vitro Cellular & Developmental Biology – Animal, 33, 763–773.
54. van der Schaft, D. W. J., van Spreeuwel, A. C. C., van Assen, H. C., & Baaijens, F. P. T. (2011).
Mechanoregulation of vascularization in aligned tissue-engineered muscle: A role for vascular
endothelial growth factor. Tissue Engineering. Part A, 17, 2857–2865.
B. Zohar et al.