46
computational models and utilization of biomechanical sensors may provide a better understanding of the means through which mechanical forces regulate the different stages of vascularization in 3D engineered tissues.
References
1. Ando, J., & Yamamoto, K. (2009). Vascular mechanobiology: Endothelial cell responses to
fluid shear stress. Circulation Journal, 73, 1983–1992.
2. Anisi, F., Salehi-Nik, N., Amoabediny, G., Pouran, B., Haghighipour, N., & ZandiehDoulabi, B. (2014). Applying shear stress to endothelial cells in a new perfusion chamber:
Hydrodynamic analysis. Journal of Artificial Organs, 17, 329–336.
3. Bellan, L. M., Singh, S. P., Henderson, P. W., Porri, T. J., Craighead, H. G., & Spector, J. A.
(2009). Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar
structures. Soft Matter, 5, 1354.
4. Beningo, K. A., Dembo, M., Kaverina, I., Small, J. V., & Wang, Y. L. (2001). Nascent focal
adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. The Journal of Cell Biology, 153, 881–888.
5. Brown, A., Burke, G., & Meenan, B. J. (2011). Modeling of shear stress experienced by endothelial cells cultured on microstructured polymer substrates in a parallel plate flow chamber.
Biotechnology and Bioengineering, 108, 1148–1158.
6. Ceccarelli, J., Cheng, A., & Putnam, A. J. (2012). Mechanical strain controls endothelial patterning during angiogenic sprouting. Cellular and Molecular Bioengineering, 5, 463–473.
7. Chang, C. C., Krishnan, L., Nunes, S. S., Church, K. H., Edgar, L. T., Boland, E. D., et al.
(2012). Determinants of microvascular network topologies in implanted neovasculatures.
Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 5–14.
8. De Smet, F., Segura, I., De Bock, K., Hohensinner, P. J., & Carmeliet, P. (2009). Mechanisms of
vessel branching filopodia on endothelial tip cells lead the way. Arteriosclerosis, Thrombosis,
and Vascular Biology, 29, 639–649.
9. Edgar, L. T., Underwood, C. J., Guilkey, J. E., Hoying, J. B., & Weiss, J. A. (2014). Extracellular
matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis.
PLoS One, 9, e85178.
10. Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem
cell lineage specification. Cell, 126, 677–689.
11. Fish, J. E., Santoro, M. M., Morton, S. U., Yu, S., Yeh, R.-F., Wythe, J. D., et al. (2008). miR126 regulates angiogenic signaling and vascular integrity. Dev. Cell, 15, 272–284.
12. Francis-Sedlak, M. E., Moya, M. L., Huang, J.-J., Lucas, S. A., Chandrasekharan, N.,
Larson, J. C., et al. (2010). Collagen glycation alters neovascularization in vitro and in vivo.
Microvascular Research, 80, 3–9.
13. Galie, P. A., Nguyen, D.-H. T., Choi, C. K., Cohen, D. M., Janmey, P. A., & Chen, C. S. (2014).
Fluid shear stress threshold regulates angiogenic sprouting. Proceedings of the National
Academy of Sciences of the United States of America, 111, 7968–7973.
14. Gassman, A. A., Kuprys, T., Ucuzian, A. A., Brey, E., Matsumura, A., Pang, Y., et al. (2011).
Three-dimensional 10% cyclic strain reduces bovine aortic endothelial cell angiogenic sprout
length and augments tubulogenesis in tubular fibrin hydrogels. Journal of Tissue Engineering
and Regenerative Medicine, 5, 375–383.
15. Gee, E., Milkiewicz, M., & Haas, T. L. (2010). p38 MAPK activity is stimulated by vascular
endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis. Journal of Cellular Physiology, 222, 120–126.
B. Zohar et al.
computational models and utilization of biomechanical sensors may provide a better understanding of the means through which mechanical forces regulate the different stages of vascularization in 3D engineered tissues.
References
1. Ando, J., & Yamamoto, K. (2009). Vascular mechanobiology: Endothelial cell responses to
fluid shear stress. Circulation Journal, 73, 1983–1992.
2. Anisi, F., Salehi-Nik, N., Amoabediny, G., Pouran, B., Haghighipour, N., & ZandiehDoulabi, B. (2014). Applying shear stress to endothelial cells in a new perfusion chamber:
Hydrodynamic analysis. Journal of Artificial Organs, 17, 329–336.
3. Bellan, L. M., Singh, S. P., Henderson, P. W., Porri, T. J., Craighead, H. G., & Spector, J. A.
(2009). Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar
structures. Soft Matter, 5, 1354.
4. Beningo, K. A., Dembo, M., Kaverina, I., Small, J. V., & Wang, Y. L. (2001). Nascent focal
adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. The Journal of Cell Biology, 153, 881–888.
5. Brown, A., Burke, G., & Meenan, B. J. (2011). Modeling of shear stress experienced by endothelial cells cultured on microstructured polymer substrates in a parallel plate flow chamber.
Biotechnology and Bioengineering, 108, 1148–1158.
6. Ceccarelli, J., Cheng, A., & Putnam, A. J. (2012). Mechanical strain controls endothelial patterning during angiogenic sprouting. Cellular and Molecular Bioengineering, 5, 463–473.
7. Chang, C. C., Krishnan, L., Nunes, S. S., Church, K. H., Edgar, L. T., Boland, E. D., et al.
(2012). Determinants of microvascular network topologies in implanted neovasculatures.
Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 5–14.
8. De Smet, F., Segura, I., De Bock, K., Hohensinner, P. J., & Carmeliet, P. (2009). Mechanisms of
vessel branching filopodia on endothelial tip cells lead the way. Arteriosclerosis, Thrombosis,
and Vascular Biology, 29, 639–649.
9. Edgar, L. T., Underwood, C. J., Guilkey, J. E., Hoying, J. B., & Weiss, J. A. (2014). Extracellular
matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis.
PLoS One, 9, e85178.
10. Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem
cell lineage specification. Cell, 126, 677–689.
11. Fish, J. E., Santoro, M. M., Morton, S. U., Yu, S., Yeh, R.-F., Wythe, J. D., et al. (2008). miR126 regulates angiogenic signaling and vascular integrity. Dev. Cell, 15, 272–284.
12. Francis-Sedlak, M. E., Moya, M. L., Huang, J.-J., Lucas, S. A., Chandrasekharan, N.,
Larson, J. C., et al. (2010). Collagen glycation alters neovascularization in vitro and in vivo.
Microvascular Research, 80, 3–9.
13. Galie, P. A., Nguyen, D.-H. T., Choi, C. K., Cohen, D. M., Janmey, P. A., & Chen, C. S. (2014).
Fluid shear stress threshold regulates angiogenic sprouting. Proceedings of the National
Academy of Sciences of the United States of America, 111, 7968–7973.
14. Gassman, A. A., Kuprys, T., Ucuzian, A. A., Brey, E., Matsumura, A., Pang, Y., et al. (2011).
Three-dimensional 10% cyclic strain reduces bovine aortic endothelial cell angiogenic sprout
length and augments tubulogenesis in tubular fibrin hydrogels. Journal of Tissue Engineering
and Regenerative Medicine, 5, 375–383.
15. Gee, E., Milkiewicz, M., & Haas, T. L. (2010). p38 MAPK activity is stimulated by vascular
endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis. Journal of Cellular Physiology, 222, 120–126.
B. Zohar et al.