34
63. Kim, D. J., Martinez-Lemus, L. A., & Davis, G. E. (2013). EB1, p150Glued, and Clasp1 control endothelial tubulogenesis through microtubule assembly, acetylation, and apical polarization. Blood, 121, 3521–3530. https://doi.org/10.1182/blood-2012-11-470179
64. Kim, D. J., Norden, P. R., Salvador, J., Barry, D. M., Bowers, S. L. K., Cleaver, O., et al.
(2017). Src- and Fyn-dependent apical membrane trafficking events control endothelial
lumen formation during vascular tube morphogenesis. PLoS One, 12, e0184461. https://doi.
org/10.1371/journal.pone.0184461
65. Kim, Y. H., Hu, H., Guevara-Gallardo, S., Lam, M. T., Fong, S. Y., & Wang, R. A. (2008).
Artery and vein size is balanced by notch and ephrin B2/EphB4 during angiogenesis.
Development, 135, 3755–3764.
66. Koh, W., Mahan, R. D., & Davis, G. E. (2008). Cdc42- and Rac1-mediated endothelial lumen
formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. Journal of Cell
Science, 121, 989–1001.
67. Koh, W., Sachidanandam, K., Stratman, A. N., Sacharidou, A., Mayo, A. M., Murphy, E. A.,
et al. (2009). Formation of endothelial lumens requires a coordinated PKC{epsilon}-, Src-,
Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. Journal
of Cell Science, 122, 1812–1822.
68. Koh, W., Stratman, A. N., Sacharidou, A., & Davis, G. E. (2008). In vitro three dimensional
collagen matrix models of endothelial lumen formation during vasculogenesis and angiogenesis. Methods in Enzymology, 443, 83–101.
69. Kwak, H. I., Mendoza, E. A., & Bayless, K. J. (2009). ADAM17 co-purifies with TIMP-3
and modulates endothelial invasion responses in three-dimensional collagen matrices. Matrix
Biology, 28, 470–479.
70. Liu, J., Fraser, S. D., Faloon, P. W., Rollins, E. L., Vom Berg, J., Starovic-Subota, O., et al.
(2007). A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 104,
13990–13995.
71. Liu, Y., & Senger, D. R. (2004). Matrix-specific activation of Src and rho initiates capillary
morphogenesis of endothelial cells. FASEB Journal, 18, 457–468.
72. Lucitti, J. L., Jones, E. A., Huang, C., Chen, J., Fraser, S. E., & Dickinson, M. E. (2007).
Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development, 134,
3317–3326.
73. Macara, I. G. (2004). Par proteins: Partners in polarization. Current Biology, 14, R160–R162.
74. Mancuso, M. R., Davis, R., Norberg, S. M., O’Brien, S., Sennino, B., Nakahara, T., et al.
(2006). Rapid vascular regrowth in tumors after reversal of VEGF inhibition. The Journal of
Clinical Investigation, 116, 2610–2621.
75. Martin-Belmonte, F., Gassama, A., Datta, A., Yu, W., Rescher, U., Gerke, V., et al. (2007).
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis
through Cdc42. Cell, 128, 383–397.
76. Miner, J. H., & Yurchenco, P. D. (2004). Laminin functions in tissue morphogenesis. Annual
Review of Cell and Developmental Biology, 20, 255–284.
77. Morla, A., & Ruoslahti, E. (1992). A fibronectin self-assembly site involved in fibronectin
matrix assembly: Reconstruction in a synthetic peptide. The Journal of Cell Biology, 118,
421–429.
78. Nakatsu, M. N., & Hughes, C. C. (2008). An optimized three-dimensional in vitro model for
the analysis of angiogenesis. Methods in Enzymology, 443, 65–82.
79. Norden, P. R., Kim, D. J., Barry, D. M., Cleaver, O. B., & Davis, G. E. (2016). Cdc42 and
k-Ras control endothelial tubulogenesis through apical membrane and cytoskeletal polarization: Novel stimulatory roles for GTPase effectors, the small GTPases, Rac2 and Rap1b,
and inhibitory influence of Arhgap31 and Rasa1. PLoS One, 11, e0147758. https://doi.
org/10.1371/journal.pone.0147758
80. Qi, J. H., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., et al. (2003).
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): Inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nature Medicine, 9, 407–415.
G. E. Davis
63. Kim, D. J., Martinez-Lemus, L. A., & Davis, G. E. (2013). EB1, p150Glued, and Clasp1 control endothelial tubulogenesis through microtubule assembly, acetylation, and apical polarization. Blood, 121, 3521–3530. https://doi.org/10.1182/blood-2012-11-470179
64. Kim, D. J., Norden, P. R., Salvador, J., Barry, D. M., Bowers, S. L. K., Cleaver, O., et al.
(2017). Src- and Fyn-dependent apical membrane trafficking events control endothelial
lumen formation during vascular tube morphogenesis. PLoS One, 12, e0184461. https://doi.
org/10.1371/journal.pone.0184461
65. Kim, Y. H., Hu, H., Guevara-Gallardo, S., Lam, M. T., Fong, S. Y., & Wang, R. A. (2008).
Artery and vein size is balanced by notch and ephrin B2/EphB4 during angiogenesis.
Development, 135, 3755–3764.
66. Koh, W., Mahan, R. D., & Davis, G. E. (2008). Cdc42- and Rac1-mediated endothelial lumen
formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. Journal of Cell
Science, 121, 989–1001.
67. Koh, W., Sachidanandam, K., Stratman, A. N., Sacharidou, A., Mayo, A. M., Murphy, E. A.,
et al. (2009). Formation of endothelial lumens requires a coordinated PKC{epsilon}-, Src-,
Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. Journal
of Cell Science, 122, 1812–1822.
68. Koh, W., Stratman, A. N., Sacharidou, A., & Davis, G. E. (2008). In vitro three dimensional
collagen matrix models of endothelial lumen formation during vasculogenesis and angiogenesis. Methods in Enzymology, 443, 83–101.
69. Kwak, H. I., Mendoza, E. A., & Bayless, K. J. (2009). ADAM17 co-purifies with TIMP-3
and modulates endothelial invasion responses in three-dimensional collagen matrices. Matrix
Biology, 28, 470–479.
70. Liu, J., Fraser, S. D., Faloon, P. W., Rollins, E. L., Vom Berg, J., Starovic-Subota, O., et al.
(2007). A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 104,
13990–13995.
71. Liu, Y., & Senger, D. R. (2004). Matrix-specific activation of Src and rho initiates capillary
morphogenesis of endothelial cells. FASEB Journal, 18, 457–468.
72. Lucitti, J. L., Jones, E. A., Huang, C., Chen, J., Fraser, S. E., & Dickinson, M. E. (2007).
Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development, 134,
3317–3326.
73. Macara, I. G. (2004). Par proteins: Partners in polarization. Current Biology, 14, R160–R162.
74. Mancuso, M. R., Davis, R., Norberg, S. M., O’Brien, S., Sennino, B., Nakahara, T., et al.
(2006). Rapid vascular regrowth in tumors after reversal of VEGF inhibition. The Journal of
Clinical Investigation, 116, 2610–2621.
75. Martin-Belmonte, F., Gassama, A., Datta, A., Yu, W., Rescher, U., Gerke, V., et al. (2007).
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis
through Cdc42. Cell, 128, 383–397.
76. Miner, J. H., & Yurchenco, P. D. (2004). Laminin functions in tissue morphogenesis. Annual
Review of Cell and Developmental Biology, 20, 255–284.
77. Morla, A., & Ruoslahti, E. (1992). A fibronectin self-assembly site involved in fibronectin
matrix assembly: Reconstruction in a synthetic peptide. The Journal of Cell Biology, 118,
421–429.
78. Nakatsu, M. N., & Hughes, C. C. (2008). An optimized three-dimensional in vitro model for
the analysis of angiogenesis. Methods in Enzymology, 443, 65–82.
79. Norden, P. R., Kim, D. J., Barry, D. M., Cleaver, O. B., & Davis, G. E. (2016). Cdc42 and
k-Ras control endothelial tubulogenesis through apical membrane and cytoskeletal polarization: Novel stimulatory roles for GTPase effectors, the small GTPases, Rac2 and Rap1b,
and inhibitory influence of Arhgap31 and Rasa1. PLoS One, 11, e0147758. https://doi.
org/10.1371/journal.pone.0147758
80. Qi, J. H., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., et al. (2003).
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): Inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nature Medicine, 9, 407–415.
G. E. Davis