190
Bone marrow-derived mesenchymal stem cells
(BM-MSCs), 151
Brain repair, 177, 178, 182
C
Cardiac biomaterials, 158, 159
Cardiac tissue engineering
alignment, 162
biochemical cues, 159, 160
biomaterials, 158, 159
cardiomyocytes, 166
cell sources
cardiomyocytes, 144, 149
endothelial cells, 149, 150
fibroblast (-like) cells, 150, 151
phenotypes, 144
cell types, 142
electrical and mechanical stimulation, 163
electrical stimulation, 163, 164
electrical vs. mechanical stimulation,
165, 166
electromechanical stimulation, 166
endogenous repair mechanisms, 142
infarct repair, 156
mechanical stimulation, 164, 165
MI results, 141
myocardium, 142
patches, 143, 144
pre-vasculature, 142
restoration of lost contractility, 143
strategies, 142, 152, 156–158
substrate stiffness, guidance and alignment
cues, 161, 162
Cardiomyocytes, 100, 129, 142, 144, 149,
151, 152, 156, 157, 159–162,
164–166
Carmichael, S.T., 181
Caspi, O., 160
Cathepsins, 79, 90
Ceccarelli, J., 43
Central nervous system (CNS), 178
Chain transfer agent (CTA), 132
Chang, C.C., 42
Chen, X., 150
Chin, K., 106
Chorioallantoic membrane (CAM), 134
Chow, D.C., 77
Chung, C.Y., 162
Coaxial nozzle system, 128, 129
Colosi, C., 128
Contractile forces, 38, 40
Cord-blood endothelial colony-forming cells
(cbECFCs), 151
Costa-Almeida, R., 150
Cui, X., 125
D
Davis, G.E., 1–30
Deroanne, C.F., 94
Digital light photopolymerization (DLP)
techniques, 132
Domingos, M., 136
Drug delivery system, 178
Duarte Campos, D.F., 126
E
EC-pericyte interactions
acute and chronic diseases, 30
Cdc42 coupling, 11, 12
growth factors, 29
human capillary tube networks, 10
in vitro and in vivo approaches, 29
MT1-MMP-dependent, 15, 16
PKCε and Src, 8, 9
polarized subapical microtubule
modifications, 12
Rho GTPases, Cdc42 and Rac1, 6, 8
small GTPases, 10–11
systems approaches, 30
in 3D extracellular matrices
blood vessel assembly, 18–20
Cdc42 and MT1-MMP, 16, 17
co-assembly process, 22, 27, 28
collagen type IV, 25, 26
ECM components, 3–5
ECM remodeling, 23–25
growth factors, 28, 29
molecular control of vascular tube
regression, 17, 18
molecular mechanisms, 21, 23
MT1-MMP, 13–15
temporal analysis, 4
TIMP-3 contributes, 26
and vascular morphogenesis, 2, 3
vascular tube morphogenesis, 5–7
vascular tube stabilization, 20, 21
tissue injury and tumorigenesis, 1
vasculature, 1
Electromechanical stimulation, 166
Electron paramagnetic resonance (EPR), 98
Emerich, D.F, 181
Endothelial cells (ECs)
bovine aortic, 43
cardiac tissue engineering, 149, 150
flow-induced shear stress, 44
Index
Bone marrow-derived mesenchymal stem cells
(BM-MSCs), 151
Brain repair, 177, 178, 182
C
Cardiac biomaterials, 158, 159
Cardiac tissue engineering
alignment, 162
biochemical cues, 159, 160
biomaterials, 158, 159
cardiomyocytes, 166
cell sources
cardiomyocytes, 144, 149
endothelial cells, 149, 150
fibroblast (-like) cells, 150, 151
phenotypes, 144
cell types, 142
electrical and mechanical stimulation, 163
electrical stimulation, 163, 164
electrical vs. mechanical stimulation,
165, 166
electromechanical stimulation, 166
endogenous repair mechanisms, 142
infarct repair, 156
mechanical stimulation, 164, 165
MI results, 141
myocardium, 142
patches, 143, 144
pre-vasculature, 142
restoration of lost contractility, 143
strategies, 142, 152, 156–158
substrate stiffness, guidance and alignment
cues, 161, 162
Cardiomyocytes, 100, 129, 142, 144, 149,
151, 152, 156, 157, 159–162,
164–166
Carmichael, S.T., 181
Caspi, O., 160
Cathepsins, 79, 90
Ceccarelli, J., 43
Central nervous system (CNS), 178
Chain transfer agent (CTA), 132
Chang, C.C., 42
Chen, X., 150
Chin, K., 106
Chorioallantoic membrane (CAM), 134
Chow, D.C., 77
Chung, C.Y., 162
Coaxial nozzle system, 128, 129
Colosi, C., 128
Contractile forces, 38, 40
Cord-blood endothelial colony-forming cells
(cbECFCs), 151
Costa-Almeida, R., 150
Cui, X., 125
D
Davis, G.E., 1–30
Deroanne, C.F., 94
Digital light photopolymerization (DLP)
techniques, 132
Domingos, M., 136
Drug delivery system, 178
Duarte Campos, D.F., 126
E
EC-pericyte interactions
acute and chronic diseases, 30
Cdc42 coupling, 11, 12
growth factors, 29
human capillary tube networks, 10
in vitro and in vivo approaches, 29
MT1-MMP-dependent, 15, 16
PKCε and Src, 8, 9
polarized subapical microtubule
modifications, 12
Rho GTPases, Cdc42 and Rac1, 6, 8
small GTPases, 10–11
systems approaches, 30
in 3D extracellular matrices
blood vessel assembly, 18–20
Cdc42 and MT1-MMP, 16, 17
co-assembly process, 22, 27, 28
collagen type IV, 25, 26
ECM components, 3–5
ECM remodeling, 23–25
growth factors, 28, 29
molecular control of vascular tube
regression, 17, 18
molecular mechanisms, 21, 23
MT1-MMP, 13–15
temporal analysis, 4
TIMP-3 contributes, 26
and vascular morphogenesis, 2, 3
vascular tube morphogenesis, 5–7
vascular tube stabilization, 20, 21
tissue injury and tumorigenesis, 1
vasculature, 1
Electromechanical stimulation, 166
Electron paramagnetic resonance (EPR), 98
Emerich, D.F, 181
Endothelial cells (ECs)
bovine aortic, 43
cardiac tissue engineering, 149, 150
flow-induced shear stress, 44
Index