111
78. Garedew, A., Kammerer, U., & Singer, D. (2009). Respiratory response of malignant and
placental cells to changes in oxygen concentration. Respiratory Physiology & Neurobiology,
165(2-3), 154–160.
79. Gerecht, S., Burdick, J. A., Ferreira, L. S., Townsend, S. A., Langer, R., & Vunjak-Novakovic,
G. (2007). Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human
embryonic stem cells. Proceedings of the National Academy of Sciences of the United States
of America, 104(27), 11298–11303.
80. Gerecht-Nir, S., Cohen, S., Ziskind, A., & Itskovitz-Eldor, J. (2004). Three-dimensional
porous alginate scaffolds provide a conducive environment for generation of well-vascularized embryoid bodies from human embryonic stem cells. Biotechnology and Bioengineering,
88(3), 313–320.
81. Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., & Quaranta, V.
(1997). Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.
Science, 277(5323), 225–228.
82. Gobin, A. S., & West, J. L. (2002). Cell migration through defined, synthetic extracellular
matrix analogues. The FASEB Journal, 16, 751–753.
83. Guaccio, A., Borselli, C., Oliviero, O., & Netti, P. A. (2008). Oxygen consumption of
chondrocytes in agarose and collagen gels: A comparative analysis. Biomaterials, 29(10),
1484–1493.
84. Hadden, W. J., Young, J. L., Holle, A. W., McFetridge, M. L., Kim, D. Y., Wijesinghe, P., et al.
(2017). Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels.
Proceedings of the National Academy of Sciences of the United States of America, 114(22),
5647–5652.
85. Hagemann, T., Robinson, S. C., Schulz, M., Trumper, L., Balkwill, F. R., & Binder, C. (2004).
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is
due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis,
25(8), 1543–1549.
86. Hanjaya-Putra, D., & Gerecht, S. (2009). Vascular engineering using human embryonic stem
cells. Biotechnology Progress, 25(1), 2–9.
87. Hanjaya-Putra, D., & Gerecht, S. (2009). Mending the failing heart with a vascularized cardiac patch. Cell Stem Cell, 5(6), 575–576.
88. Hanjaya-Putra, D., Yee, J., Ceci, D., Truitt, R., Yee, D., & Gerecht, S. (2009). Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial
progenitor cells. Journal of Cellular and Molecular Medicine, 14(10), 2436–2447.
89. Hanjaya-Putra, D., Bose, V., Shen, Y. I., Yee, J., Khetan, S., Fox-Talbot, K., et al. (2011).
Controlled activation of morphogenesis to generate a functional human microvasculature in
a synthetic matrix. Blood, 118(3), 804–815.
90. Hanjaya-Putra, D., Wong, K. T., Hirotsu, K., Khetan, S., Burdick, J. A., & Gerecht, S. (2012).
Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in
hyaluronan hydrogels. Biomaterials, 33(26), 6123–6131.
91. Harrison, J. S., Rameshwar, P., Chang, V., & Bandari, P. (2002). Oxygen saturation in the
bone marrow of healthy volunteers. Blood, 99(1), 394.
92. Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., et al. (2002).
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 109(5), 625–637.
93. Helmlinger, G., Endo, M., Ferrara, N., Hlatky, L., & Jain, R. K. (2000). Formation of endothelial cell networks. Nature, 405(6783), 139–141.
94. Hirota, K., & Semenza, G. L. (2005). Regulation of hypoxia-inducible factor 1 by prolyl and
asparaginyl hydroxylases. Biochemical and Biophysical Research Communications, 338(1),
610–616.
95. Hirschi, K. K., & D’Amore, P. A. (1996). Pericytes in the microvasculature. Cardiovascular
Research, 32(4), 687–698.
96. Hirschi, K. K., Ingram, D. A., & Yoder, M. C. (2008). Assessing identity, phenotype, and fate
of endothelial progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(9),
1584–1595.
4 Hypoxia and Matrix Manipulation for Vascular Engineering
78. Garedew, A., Kammerer, U., & Singer, D. (2009). Respiratory response of malignant and
placental cells to changes in oxygen concentration. Respiratory Physiology & Neurobiology,
165(2-3), 154–160.
79. Gerecht, S., Burdick, J. A., Ferreira, L. S., Townsend, S. A., Langer, R., & Vunjak-Novakovic,
G. (2007). Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human
embryonic stem cells. Proceedings of the National Academy of Sciences of the United States
of America, 104(27), 11298–11303.
80. Gerecht-Nir, S., Cohen, S., Ziskind, A., & Itskovitz-Eldor, J. (2004). Three-dimensional
porous alginate scaffolds provide a conducive environment for generation of well-vascularized embryoid bodies from human embryonic stem cells. Biotechnology and Bioengineering,
88(3), 313–320.
81. Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., & Quaranta, V.
(1997). Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.
Science, 277(5323), 225–228.
82. Gobin, A. S., & West, J. L. (2002). Cell migration through defined, synthetic extracellular
matrix analogues. The FASEB Journal, 16, 751–753.
83. Guaccio, A., Borselli, C., Oliviero, O., & Netti, P. A. (2008). Oxygen consumption of
chondrocytes in agarose and collagen gels: A comparative analysis. Biomaterials, 29(10),
1484–1493.
84. Hadden, W. J., Young, J. L., Holle, A. W., McFetridge, M. L., Kim, D. Y., Wijesinghe, P., et al.
(2017). Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels.
Proceedings of the National Academy of Sciences of the United States of America, 114(22),
5647–5652.
85. Hagemann, T., Robinson, S. C., Schulz, M., Trumper, L., Balkwill, F. R., & Binder, C. (2004).
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is
due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis,
25(8), 1543–1549.
86. Hanjaya-Putra, D., & Gerecht, S. (2009). Vascular engineering using human embryonic stem
cells. Biotechnology Progress, 25(1), 2–9.
87. Hanjaya-Putra, D., & Gerecht, S. (2009). Mending the failing heart with a vascularized cardiac patch. Cell Stem Cell, 5(6), 575–576.
88. Hanjaya-Putra, D., Yee, J., Ceci, D., Truitt, R., Yee, D., & Gerecht, S. (2009). Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial
progenitor cells. Journal of Cellular and Molecular Medicine, 14(10), 2436–2447.
89. Hanjaya-Putra, D., Bose, V., Shen, Y. I., Yee, J., Khetan, S., Fox-Talbot, K., et al. (2011).
Controlled activation of morphogenesis to generate a functional human microvasculature in
a synthetic matrix. Blood, 118(3), 804–815.
90. Hanjaya-Putra, D., Wong, K. T., Hirotsu, K., Khetan, S., Burdick, J. A., & Gerecht, S. (2012).
Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in
hyaluronan hydrogels. Biomaterials, 33(26), 6123–6131.
91. Harrison, J. S., Rameshwar, P., Chang, V., & Bandari, P. (2002). Oxygen saturation in the
bone marrow of healthy volunteers. Blood, 99(1), 394.
92. Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., et al. (2002).
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 109(5), 625–637.
93. Helmlinger, G., Endo, M., Ferrara, N., Hlatky, L., & Jain, R. K. (2000). Formation of endothelial cell networks. Nature, 405(6783), 139–141.
94. Hirota, K., & Semenza, G. L. (2005). Regulation of hypoxia-inducible factor 1 by prolyl and
asparaginyl hydroxylases. Biochemical and Biophysical Research Communications, 338(1),
610–616.
95. Hirschi, K. K., & D’Amore, P. A. (1996). Pericytes in the microvasculature. Cardiovascular
Research, 32(4), 687–698.
96. Hirschi, K. K., Ingram, D. A., & Yoder, M. C. (2008). Assessing identity, phenotype, and fate
of endothelial progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(9),
1584–1595.
4 Hypoxia and Matrix Manipulation for Vascular Engineering