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59. Ehrbar, M., Metters, A., Zammaretti, P., Hubbell, J. A., & Zisch, A. H. (2005). Endothelial
cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential
susceptibilities to local cellular activity. Journal of Controlled Release, 101(1-3), 93–109.
60. Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem
cell lineage specification. Cell, 126(4), 677–689.
61. Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., et al. (2009).
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form
the premetastatic niche. Cancer Cell, 15(1), 35–44.
62. Evanko, S. P., Parks, W. T., & Wight, T. N. (2004). Intracellular hyaluronan in arterial smooth
muscle cells: Association with microtubules, RHAMM, and the mitotic spindle. The Journal
of Histochemistry and Cytochemistry, 52(12), 1525–1535.
63. Evans, A. M., Mustard, K. J., Wyatt, C. N., Peers, C., Dipp, M., Kumar, P., et al. (2005). Does
AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation
by hypoxia to calcium signaling in O2-sensing cells? The Journal of Biological Chemistry,
280(50), 41504–41511.
64. Ezashi, T., Das, P., & Roberts, R. M. (2005). Low O2 tensions and the prevention of differentiation of hES cells. Proceedings of the National Academy of Sciences of the United States of
America, 102(13), 4783–4788.
65. Fahling, M., Perlewitz, A., Doller, A., & Thiele, B. J. (2004). Regulation of collagen prolyl
4-hydroxylase and matrix metalloproteinases in fibrosarcoma cells by hypoxia. Comparative
Biochemistry and Physiology, Part C: Toxicology & Pharmacology, 139(1-3), 119–126.
66. Figallo, E., Cannizzaro, C., Gerecht, S., Burdick, J. A., Langer, R., Elvassore, N., et al.
(2007). Micro-bioreactor array for controlling cellular microenvironments. Lab on a Chip,
7(6), 710–719.
67. Folkman, J., Haudenschild, C. C., & Zetter, B. R. (1979). Long-term culture of capillary
endothelial cells. Proceedings of the National Academy of Sciences of the United States of
America, 76(10), 5217–5221.
68. Fong, G. H. (2009). Regulation of angiogenesis by oxygen sensing mechanisms. Journal of
Molecular Medicine, 87(6), 549–560.
69. Forristal, C. E., Wright, K. L., Hanley, N. A., Oreffo, R. O., & Houghton, F. D. (2010).
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem
cells cultured at reduced oxygen tensions. Reproduction, 139(1), 85–97.
70. Fraisl, P., Mazzone, M., Schmidt, T., & Carmeliet, P. (2009). Regulation of angiogenesis by
oxygen and metabolism. Developmental Cell, 16(2), 167–179.
71. Francis, S. E., Goh, K. L., Hodivala-Dilke, K., Bader, B. L., Stark, M., Davidson, D., et
al. (2002). Central roles of alpha5beta1 integrin and fibronectin in vascular development in
mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis, and Vascular Biology,
22(6), 927–933.
72. Frei, R., Gaucher, C., Poulton, S. W., & Canfield, D. E. (2009). Fluctuations in Precambrian
atmospheric oxygenation recorded by chromium isotopes. Nature, 461(7261), 250–253.
73. Fukumura, D., Kashiwagi, S., & Jain, R. K. (2006). The role of nitric oxide in tumour progression. Nature Reviews. Cancer, 6(7), 521–534.
74. Funamoto, K., Zervantonakis, I. K., Liu, Y. C., Ochs, C. J., Kim, C., & Kamm, R. D. (2012).
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture
under a controlled hypoxic environment. Lab on a Chip, 12(22), 4855–4863.
75. Gafni, Y., Zilberman, Y., Ophir, Z., Abramovitch, R., Jaffe, M., Gazit, Z., et al. (2006). Design
of a filamentous polymeric scaffold for in vivo guided angiogenesis. Tissue Engineering,
12(11), 3021–3034.
76. Galban, C. J., & Locke, B. R. (1999). Effects of spatial variation of cells and nutrient and
product concentrations coupled with product inhibition on cell growth in a polymer scaffold.
Biotechnology and Bioengineering, 64(6), 633–643.
77. Galban, C. J., & Locke, B. R. (1999). Analysis of cell growth kinetics and substrate diffusion
in a polymer scaffold. Biotechnology and Bioengineering, 65(2), 121–132.
M. R. Blatchley et al.
59. Ehrbar, M., Metters, A., Zammaretti, P., Hubbell, J. A., & Zisch, A. H. (2005). Endothelial
cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential
susceptibilities to local cellular activity. Journal of Controlled Release, 101(1-3), 93–109.
60. Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem
cell lineage specification. Cell, 126(4), 677–689.
61. Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., et al. (2009).
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form
the premetastatic niche. Cancer Cell, 15(1), 35–44.
62. Evanko, S. P., Parks, W. T., & Wight, T. N. (2004). Intracellular hyaluronan in arterial smooth
muscle cells: Association with microtubules, RHAMM, and the mitotic spindle. The Journal
of Histochemistry and Cytochemistry, 52(12), 1525–1535.
63. Evans, A. M., Mustard, K. J., Wyatt, C. N., Peers, C., Dipp, M., Kumar, P., et al. (2005). Does
AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation
by hypoxia to calcium signaling in O2-sensing cells? The Journal of Biological Chemistry,
280(50), 41504–41511.
64. Ezashi, T., Das, P., & Roberts, R. M. (2005). Low O2 tensions and the prevention of differentiation of hES cells. Proceedings of the National Academy of Sciences of the United States of
America, 102(13), 4783–4788.
65. Fahling, M., Perlewitz, A., Doller, A., & Thiele, B. J. (2004). Regulation of collagen prolyl
4-hydroxylase and matrix metalloproteinases in fibrosarcoma cells by hypoxia. Comparative
Biochemistry and Physiology, Part C: Toxicology & Pharmacology, 139(1-3), 119–126.
66. Figallo, E., Cannizzaro, C., Gerecht, S., Burdick, J. A., Langer, R., Elvassore, N., et al.
(2007). Micro-bioreactor array for controlling cellular microenvironments. Lab on a Chip,
7(6), 710–719.
67. Folkman, J., Haudenschild, C. C., & Zetter, B. R. (1979). Long-term culture of capillary
endothelial cells. Proceedings of the National Academy of Sciences of the United States of
America, 76(10), 5217–5221.
68. Fong, G. H. (2009). Regulation of angiogenesis by oxygen sensing mechanisms. Journal of
Molecular Medicine, 87(6), 549–560.
69. Forristal, C. E., Wright, K. L., Hanley, N. A., Oreffo, R. O., & Houghton, F. D. (2010).
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem
cells cultured at reduced oxygen tensions. Reproduction, 139(1), 85–97.
70. Fraisl, P., Mazzone, M., Schmidt, T., & Carmeliet, P. (2009). Regulation of angiogenesis by
oxygen and metabolism. Developmental Cell, 16(2), 167–179.
71. Francis, S. E., Goh, K. L., Hodivala-Dilke, K., Bader, B. L., Stark, M., Davidson, D., et
al. (2002). Central roles of alpha5beta1 integrin and fibronectin in vascular development in
mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis, and Vascular Biology,
22(6), 927–933.
72. Frei, R., Gaucher, C., Poulton, S. W., & Canfield, D. E. (2009). Fluctuations in Precambrian
atmospheric oxygenation recorded by chromium isotopes. Nature, 461(7261), 250–253.
73. Fukumura, D., Kashiwagi, S., & Jain, R. K. (2006). The role of nitric oxide in tumour progression. Nature Reviews. Cancer, 6(7), 521–534.
74. Funamoto, K., Zervantonakis, I. K., Liu, Y. C., Ochs, C. J., Kim, C., & Kamm, R. D. (2012).
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture
under a controlled hypoxic environment. Lab on a Chip, 12(22), 4855–4863.
75. Gafni, Y., Zilberman, Y., Ophir, Z., Abramovitch, R., Jaffe, M., Gazit, Z., et al. (2006). Design
of a filamentous polymeric scaffold for in vivo guided angiogenesis. Tissue Engineering,
12(11), 3021–3034.
76. Galban, C. J., & Locke, B. R. (1999). Effects of spatial variation of cells and nutrient and
product concentrations coupled with product inhibition on cell growth in a polymer scaffold.
Biotechnology and Bioengineering, 64(6), 633–643.
77. Galban, C. J., & Locke, B. R. (1999). Analysis of cell growth kinetics and substrate diffusion
in a polymer scaffold. Biotechnology and Bioengineering, 65(2), 121–132.
M. R. Blatchley et al.