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65. Alsirawan MB, Mohammad M, Al-kasmi B, Alhareth K, El-Hammadi M (2013) Development
and validation of a simple HPLC method for the determination of ibuprofen sticking onto
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66. Stephenson JB, Flater ML, Bain LT (2016) Analysis of Valproic acid, salicylic acid and
ibuprofen in whole blood by GC-MS. J Anal Toxicol 40(8):649–652. https://doi.org/10.1093/
jat/bkw079
67. Liang G, Man Y, Jin X, Pan L, Liu X (2016) Aptamer-based biosensor for label-free detection
of ethanolamine by electrochemical impedance spectroscopy. Anal Chim Acta 936:222–228.
https://doi.org/10.1016/j.aca.2016.06.056
68. Pilehvar S, Dierckx T, Blust R, Breugelmans T, De Wael K (2014) An electrochemical
impedimetric aptasensing platform for sensitive and selective detection of small molecules
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69. Bahner N, Reich P, Frense D, Menger M, Schieke K, Beckmann D (2018) An aptamer-based
biosensor for detection of doxorubicin by electrochemical impedance spectroscopy. Anal
Bioanal Chem 410(5):1453–1462. https://doi.org/10.1007/s00216-017-0786-8
70. Erdem A, Karadeniz H, Caliskan A (2011) Dendrimer modified graphite sensors for detection
of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy. Analyst 136(5):1041–1045. https://doi.org/10.1039/c0an00357c
71. Zhu B, Alsager OA, Kumar S, Hodgkiss JM, Travas-Sejdic J (2015) Label-free electrochemical aptasensor for femtomolar detection of 17beta-estradiol. Biosens Bioelectron 70:398–403.
https://doi.org/10.1016/j.bios.2015.03.050
72. Lin Z, Chen L, Zhang G, Liu Q, Qiu B, Cai Z, Chen G (2012) Label-free aptamer-based
electrochemical impedance biosensor for 17beta-estradiol. Analyst 137(4):819–822. https://
doi.org/10.1039/c1an15856b
73. Contreras Jiménez G, Eissa S, Ng A, Alhadrami H, Zourob M, Siaj M (2015) Aptamer-based
label-free impedimetric biosensor for detection of progesterone. Anal Chem 87(2):1075–1082.
https://doi.org/10.1021/ac503639s
74. Commission Regulation (EC) No 181/2003 (2003) 2003/181/EC: commission decision of
13 March 2003 amending decision 2002/657/EC as regards the setting of minimum required
performance limits (MRPLs) for certain residues in food of animal origin
75. Brosel-Oliu S, Ferreira R, Uria N, Abramova N, Gargallo R, Muñoz-Pascual F-X, Bratov A
(2018) Novel impedimetric aptasensor for label-free detection of Escherichia coli O157:H7.
Sensors Actuators B Chem 255:2988–2995. https://doi.org/10.1016/j.snb.2017.09.121
76. Eissa S, Siaj M, Zourob M (2015) Aptamer-based competitive electrochemical biosensor for
brevetoxin-2. Biosens Bioelectron 69:148–154. https://doi.org/10.1016/j.bios.2015.01.055
77. Zhao Z, Chen H, Ma L, Liu D, Wang Z (2015) A label-free electrochemical impedance
aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites.
Analyst 140(16):5570–5577. https://doi.org/10.1039/c5an00704f
78. Lin Z, Huang H, Xu Y, Gao X, Qiu B, Chen X, Chen G (2013) Determination of microcystinLR in water by a label-free aptamer based electrochemical impedance biosensor. Talanta
103:371–374. https://doi.org/10.1016/j.talanta.2012.10.081
79. Madianos L, Tsekenis G, Skotadis E, Patsiouras L, Tsoukalas D (2018) A highly sensitive
impedimetric aptasensor for the selective detection of acetamiprid and atrazine based on
microwires formed by platinum nanoparticles. Biosens Bioelectron 101:268–274. https://doi.
org/10.1016/j.bios.2017.10.034
80. Azadbakht A, Roushani M, Abbasi AR, Derikvand Z (2016) A novel impedimetric aptasensor,
based on functionalized carbon nanotubes and prussian blue as labels. Anal Biochem
512:58–69. https://doi.org/10.1016/j.ab.2016.08.006
Impedimetric Aptamer-Based Biosensors: Applications
85
https://doi.org/10.1016/j.msec.2017.03.023
65. Alsirawan MB, Mohammad M, Al-kasmi B, Alhareth K, El-Hammadi M (2013) Development
and validation of a simple HPLC method for the determination of ibuprofen sticking onto
punch faces. Int J Pharm Pharm Sci 5(Suppl 4):227–231
66. Stephenson JB, Flater ML, Bain LT (2016) Analysis of Valproic acid, salicylic acid and
ibuprofen in whole blood by GC-MS. J Anal Toxicol 40(8):649–652. https://doi.org/10.1093/
jat/bkw079
67. Liang G, Man Y, Jin X, Pan L, Liu X (2016) Aptamer-based biosensor for label-free detection
of ethanolamine by electrochemical impedance spectroscopy. Anal Chim Acta 936:222–228.
https://doi.org/10.1016/j.aca.2016.06.056
68. Pilehvar S, Dierckx T, Blust R, Breugelmans T, De Wael K (2014) An electrochemical
impedimetric aptasensing platform for sensitive and selective detection of small molecules
such as chloramphenicol. Sensors 14(7):12059–12069. https://doi.org/10.3390/s140712059
69. Bahner N, Reich P, Frense D, Menger M, Schieke K, Beckmann D (2018) An aptamer-based
biosensor for detection of doxorubicin by electrochemical impedance spectroscopy. Anal
Bioanal Chem 410(5):1453–1462. https://doi.org/10.1007/s00216-017-0786-8
70. Erdem A, Karadeniz H, Caliskan A (2011) Dendrimer modified graphite sensors for detection
of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy. Analyst 136(5):1041–1045. https://doi.org/10.1039/c0an00357c
71. Zhu B, Alsager OA, Kumar S, Hodgkiss JM, Travas-Sejdic J (2015) Label-free electrochemical aptasensor for femtomolar detection of 17beta-estradiol. Biosens Bioelectron 70:398–403.
https://doi.org/10.1016/j.bios.2015.03.050
72. Lin Z, Chen L, Zhang G, Liu Q, Qiu B, Cai Z, Chen G (2012) Label-free aptamer-based
electrochemical impedance biosensor for 17beta-estradiol. Analyst 137(4):819–822. https://
doi.org/10.1039/c1an15856b
73. Contreras Jiménez G, Eissa S, Ng A, Alhadrami H, Zourob M, Siaj M (2015) Aptamer-based
label-free impedimetric biosensor for detection of progesterone. Anal Chem 87(2):1075–1082.
https://doi.org/10.1021/ac503639s
74. Commission Regulation (EC) No 181/2003 (2003) 2003/181/EC: commission decision of
13 March 2003 amending decision 2002/657/EC as regards the setting of minimum required
performance limits (MRPLs) for certain residues in food of animal origin
75. Brosel-Oliu S, Ferreira R, Uria N, Abramova N, Gargallo R, Muñoz-Pascual F-X, Bratov A
(2018) Novel impedimetric aptasensor for label-free detection of Escherichia coli O157:H7.
Sensors Actuators B Chem 255:2988–2995. https://doi.org/10.1016/j.snb.2017.09.121
76. Eissa S, Siaj M, Zourob M (2015) Aptamer-based competitive electrochemical biosensor for
brevetoxin-2. Biosens Bioelectron 69:148–154. https://doi.org/10.1016/j.bios.2015.01.055
77. Zhao Z, Chen H, Ma L, Liu D, Wang Z (2015) A label-free electrochemical impedance
aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites.
Analyst 140(16):5570–5577. https://doi.org/10.1039/c5an00704f
78. Lin Z, Huang H, Xu Y, Gao X, Qiu B, Chen X, Chen G (2013) Determination of microcystinLR in water by a label-free aptamer based electrochemical impedance biosensor. Talanta
103:371–374. https://doi.org/10.1016/j.talanta.2012.10.081
79. Madianos L, Tsekenis G, Skotadis E, Patsiouras L, Tsoukalas D (2018) A highly sensitive
impedimetric aptasensor for the selective detection of acetamiprid and atrazine based on
microwires formed by platinum nanoparticles. Biosens Bioelectron 101:268–274. https://doi.
org/10.1016/j.bios.2017.10.034
80. Azadbakht A, Roushani M, Abbasi AR, Derikvand Z (2016) A novel impedimetric aptasensor,
based on functionalized carbon nanotubes and prussian blue as labels. Anal Biochem
512:58–69. https://doi.org/10.1016/j.ab.2016.08.006
Impedimetric Aptamer-Based Biosensors: Applications
85