basic research on aptamer-target binding and develop models to enable effective
biosensor design.
Acknowledgments We thank SciGraphics (contact@scigraphics.de) for contributing the illustrations for this chapter.
References
1. Jo H, Kim SK, Youn H, Lee H, Lee K, Jeong J, Mok J, Kim SH, Park HS, Ban C (2016) A
highly sensitive and selective impedimetric aptasensor for interleukin-17 receptor A. Biosens
Bioelectron 81:80–86. https://doi.org/10.1016/j.bios.2016.02.050
2. Ocaña C, del Valle M (2014) Signal amplification for thrombin impedimetric aptasensor:
sandwich protocol and use of gold-streptavidin nanoparticles. Biosens Bioelectron
54:408–414. https://doi.org/10.1016/j.bios.2013.10.068
3. Qi H, Shangguan L, Li C, Li X, Gao Q, Zhang C (2013) Sensitive and antifouling
impedimetric aptasensor for the determination of thrombin in undiluted serum sample. Biosens
Bioelectron 39(1):324–328. https://doi.org/10.1016/j.bios.2012.07.040
4. Snyderman R (2012) Personalized health care: from theory to practice. Biotechnol J 7
(8):973–979. https://doi.org/10.1002/biot.201100297
5. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY,
Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC, Taubert K, Tracy RP, Vinicor F (2003)
Markers of inflammation and cardiovascular disease application to clinical and public health
practice – a statement for healthcare professionals from the centers for disease control and
prevention and the American Heart Association. Circulation 107(3):499–511. https://doi.org/
10.1161/01.Cir.0000052939.59093.45
6. Qureshi A, Gurbuz Y, Kallempudi S, Niazi JH (2010) Label-free RNA aptamer-based
capacitive biosensor for the detection of C-reactive protein. Phys Chem Chem Phys 12
(32):9176–9182. https://doi.org/10.1039/c004133e
7. Piccoli J, Hein R, El-Sagheer AH, Brown T, Cilli EM, Bueno PR, Davis JJ (2018) Redox
capacitive assaying of C-reactive protein at a peptide supported aptamer interface. Anal Chem
90(5):3005–3008. https://doi.org/10.1021/acs.analchem.7b05374
8. Aray A, Chiavaioli F, Arjmand M, Trono C, Tombelli S, Giannetti A, Cennamo N,
Soltanolkotabi M, Zeni L, Baldini F (2016) SPR-based plastic optical fibre biosensor for the
detection of C-reactive protein in serum. J Biophotonics 9(10):1077–1084. https://doi.org/10.
1002/jbio.201500315
9. Bryan T, Luo XL, Bueno PR, Davis JJ (2013) An optimised electrochemical biosensor for the
label-free detection of C-reactive protein in blood. Biosens Bioelectron 39(1):94–98. https://
doi.org/10.1016/j.bios.2012.06.051
10. Bing X, Wang G (2017) Label free C-reactive protein detection based on an electrochemical
sensor for clinical application. Int J Electrochem Sci 12(7):6304–6314
11. Wu B, Jiang R, Wang Q, Huang J, Yang XH, Wang KM, Li WS, Chen ND, Li Q (2016)
Detection of C-reactive protein using nanoparticle- enhanced surface plasmon resonance using
an aptamer-antibody sandwich assay. Chem Commun 52(17):3568–3571. https://doi.org/10.
1039/c5cc10486f
12. Zubiate P, Zamarreno CR, Sanchez R, Matias IR, Arregui FJ (2017) High sensitive and
selective C-reactive protein detection by means of lossy mode resonance based optical fiber
devices. Biosens Bioelectron 93:176–181. https://doi.org/10.1016/j.bios.2016.09.020
13. Vasilescu A, Wang Q, Li MS, Boukherroub R, Szunerits S (2016) Aptamer-based electrochemical sensing of lysozyme. Chemosensors 4(2):20. https://doi.org/10.3390/
chemosensors4020010
Impedimetric Aptamer-Based Biosensors: Applications
81
biosensor design.
Acknowledgments We thank SciGraphics (contact@scigraphics.de) for contributing the illustrations for this chapter.
References
1. Jo H, Kim SK, Youn H, Lee H, Lee K, Jeong J, Mok J, Kim SH, Park HS, Ban C (2016) A
highly sensitive and selective impedimetric aptasensor for interleukin-17 receptor A. Biosens
Bioelectron 81:80–86. https://doi.org/10.1016/j.bios.2016.02.050
2. Ocaña C, del Valle M (2014) Signal amplification for thrombin impedimetric aptasensor:
sandwich protocol and use of gold-streptavidin nanoparticles. Biosens Bioelectron
54:408–414. https://doi.org/10.1016/j.bios.2013.10.068
3. Qi H, Shangguan L, Li C, Li X, Gao Q, Zhang C (2013) Sensitive and antifouling
impedimetric aptasensor for the determination of thrombin in undiluted serum sample. Biosens
Bioelectron 39(1):324–328. https://doi.org/10.1016/j.bios.2012.07.040
4. Snyderman R (2012) Personalized health care: from theory to practice. Biotechnol J 7
(8):973–979. https://doi.org/10.1002/biot.201100297
5. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY,
Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC, Taubert K, Tracy RP, Vinicor F (2003)
Markers of inflammation and cardiovascular disease application to clinical and public health
practice – a statement for healthcare professionals from the centers for disease control and
prevention and the American Heart Association. Circulation 107(3):499–511. https://doi.org/
10.1161/01.Cir.0000052939.59093.45
6. Qureshi A, Gurbuz Y, Kallempudi S, Niazi JH (2010) Label-free RNA aptamer-based
capacitive biosensor for the detection of C-reactive protein. Phys Chem Chem Phys 12
(32):9176–9182. https://doi.org/10.1039/c004133e
7. Piccoli J, Hein R, El-Sagheer AH, Brown T, Cilli EM, Bueno PR, Davis JJ (2018) Redox
capacitive assaying of C-reactive protein at a peptide supported aptamer interface. Anal Chem
90(5):3005–3008. https://doi.org/10.1021/acs.analchem.7b05374
8. Aray A, Chiavaioli F, Arjmand M, Trono C, Tombelli S, Giannetti A, Cennamo N,
Soltanolkotabi M, Zeni L, Baldini F (2016) SPR-based plastic optical fibre biosensor for the
detection of C-reactive protein in serum. J Biophotonics 9(10):1077–1084. https://doi.org/10.
1002/jbio.201500315
9. Bryan T, Luo XL, Bueno PR, Davis JJ (2013) An optimised electrochemical biosensor for the
label-free detection of C-reactive protein in blood. Biosens Bioelectron 39(1):94–98. https://
doi.org/10.1016/j.bios.2012.06.051
10. Bing X, Wang G (2017) Label free C-reactive protein detection based on an electrochemical
sensor for clinical application. Int J Electrochem Sci 12(7):6304–6314
11. Wu B, Jiang R, Wang Q, Huang J, Yang XH, Wang KM, Li WS, Chen ND, Li Q (2016)
Detection of C-reactive protein using nanoparticle- enhanced surface plasmon resonance using
an aptamer-antibody sandwich assay. Chem Commun 52(17):3568–3571. https://doi.org/10.
1039/c5cc10486f
12. Zubiate P, Zamarreno CR, Sanchez R, Matias IR, Arregui FJ (2017) High sensitive and
selective C-reactive protein detection by means of lossy mode resonance based optical fiber
devices. Biosens Bioelectron 93:176–181. https://doi.org/10.1016/j.bios.2016.09.020
13. Vasilescu A, Wang Q, Li MS, Boukherroub R, Szunerits S (2016) Aptamer-based electrochemical sensing of lysozyme. Chemosensors 4(2):20. https://doi.org/10.3390/
chemosensors4020010
Impedimetric Aptamer-Based Biosensors: Applications
81