Fig. 4
Design for detection and capture of CTCs by an impedimetric aptasensor: Aptamers are hybridized to complementary DNA capture probes on the sensor
surface. Then, CTCs from the sample bind to these aptamers and an increase in impedance is measured. Cells are released by the application of a uracil excision
enzyme, specifically targeting the aptamer due to its uracil bases. Recovered CTCs can be used for further experiments and the recovered sensor can be reused.
(Adapted from [40], with permission from Elsevier)
54
J.-A. Preuß et al.
Design for detection and capture of CTCs by an impedimetric aptasensor: Aptamers are hybridized to complementary DNA capture probes on the sensor
surface. Then, CTCs from the sample bind to these aptamers and an increase in impedance is measured. Cells are released by the application of a uracil excision
enzyme, specifically targeting the aptamer due to its uracil bases. Recovered CTCs can be used for further experiments and the recovered sensor can be reused.
(Adapted from [40], with permission from Elsevier)
54
J.-A. Preuß et al.