8. Li B, Ellington AD (2012) Electrochemical techniques as powerful readout methods
for aptamer-based biosensors (Chapter 9). In: Fox KR, Brown T (eds) DNA conjugates
and sensors. RSC biomolecular sciences, vol 26. The Royal Society of Chemistry, London,
pp 211–241. https://doi.org/10.1039/9781849734936-00211
9. Chiorcea-Paquim A-M, Oliveira-Brett AM (2014) Redox behaviour of G-quadruplexes.
Electrochim Acta 126:162–170. https://doi.org/10.1016/j.electacta.2013.07.150
10. Muñoz J, Montes R, Baeza M (2017) Trends in electrochemical impedance spectroscopy
involving nanocomposite transducers: characterization, architecture surface and bio-sensing.
TrAC Trends Anal Chem 97:201–215. https://doi.org/10.1016/j.trac.2017.08.012
11. Grimnes S, Martinsen ØG (2015) Chapter 11 - History of bioimpedance and bioelectricity.
In: Bioimpedance and bioelectricity basics, 3rd edn. Academic Press, Cambridge, pp 495–504.
https://doi.org/10.1016/B978-0-12-411470-8.00011-8
12. Sanchez B, Vandersteen G, Bragos R, Schoukens J (2011) Optimal multisine excitation design
for broadband electrical impedance spectroscopy. Meas Sci Technol 22(11):115601. https://doi.
org/10.1088/0957-0233/22/11/115601
13. Pauwels D, Pilehvar S, Geboes B, Hubin A, De Wael K, Breugelmans T (2016) A new
multisine-based impedimetric aptasensing platform. Electrochem Commun 71:23–27. https://
doi.org/10.1016/j.elecom.2016.07.010
14. Pilehvar S, Ahmad Rather J, Dardenne F, Robbens J, Blust R, de Wael K (2014) Carbon
nanotubes based electrochemical aptasensing platform for the detection of hydroxylated
polychlorinated biphenyl in human blood serum. Biosens Bioelectron 54:78–84. https://doi.
org/10.1016/j.bios.2013.10.018
15. Yoo J-S, Park S-M (2000) An electrochemical impedance measurement technique employing
Fourier transform. Anal Chem 72(9):2035–2041. https://doi.org/10.1021/ac9907540
16. Jurczakowski R, Lasia A (2004) Limitations of the potential step technique to impedance
measurements using discrete time Fourier transform. Anal Chem 76(17):5033–5038. https://
doi.org/10.1021/ac0493929
17. Lim T, Lee SY, Yang J, Hwang SY, Ahn Y (2016) Microfluidic biochips for
simple impedimetric detection of thrombin based on label-free DNA aptamers. BioChip J
11(2):109–115. https://doi.org/10.1007/s13206-016-1203-7
18. Loo AH, Bonanni A, Pumera M (2012) Impedimetric thrombin aptasensor based on chemically
modified graphenes. Nanoscale 4(1):143–147. https://doi.org/10.1039/c1nr10966a
19. Meini N, Farre C, Chaix C, Kherrat R, Dzyadevych S, Jaffrezic-Renault N (2012)
A sensitive and selective thrombin impedimetric aptasensor based on tailored aptamers
obtained by solid-phase synthesis. Sens Actuators B 166–167:715–720. https://doi.org/10.
1016/j.snb.2012.03.046
20. Miodek A, Regan EM, Bhalla N, Hopkins NA, Goodchild SA, Estrela P (2015) Optimisation
and characterisation of anti-fouling ternary SAM layers for impedance-based aptasensors.
Sensors 15(10):25015–25032. https://doi.org/10.3390/s151025015
21. Oyama N, Ohsaka T, Yamamoto N, Matsui J, Hatozaki O (1989) Determination of the heterogeneous electron-transfer rate constants for the redox couples Mo(CN)
4À/3À
8 , W(CN)
4À/3À
8 ,
Fe(CN)
4À/3À
6 , Os(CN)
4À/3À
6 and IrCl
3À/2À
6 using fast sweep cyclic voltammetry at carbon fibre
electrodes. J Electroanal Chem Interfacial Electrochem 265(1):297–304
22. Peng K, Zhao H, Xie P, Hu S, Yuan Y, Yuan R, Wu X (2016) Impedimetric aptasensor for
nuclear factor kappa B with peroxidase-like mimic coupled DNA nanoladders as enhancer.
Biosens Bioelectron 81:1–7. https://doi.org/10.1016/j.bios.2015.12.039
23. Chandrasekaran AR (2016) Designer DNA architectures: applications in nanomedicine.
Nanobiomedicine 3:6. https://doi.org/10.5772/63228
24. Sheng QL, Liu RX, Zheng JB, Zhu JJ (2013) Reversible switches of DNA nanostructures between
“Closed” and “Open” states and their biosensing applications. Nanoscale 5(16):7505–7511.
https://doi.org/10.1039/c3nr01576a
38
P. Reich et al.
for aptamer-based biosensors (Chapter 9). In: Fox KR, Brown T (eds) DNA conjugates
and sensors. RSC biomolecular sciences, vol 26. The Royal Society of Chemistry, London,
pp 211–241. https://doi.org/10.1039/9781849734936-00211
9. Chiorcea-Paquim A-M, Oliveira-Brett AM (2014) Redox behaviour of G-quadruplexes.
Electrochim Acta 126:162–170. https://doi.org/10.1016/j.electacta.2013.07.150
10. Muñoz J, Montes R, Baeza M (2017) Trends in electrochemical impedance spectroscopy
involving nanocomposite transducers: characterization, architecture surface and bio-sensing.
TrAC Trends Anal Chem 97:201–215. https://doi.org/10.1016/j.trac.2017.08.012
11. Grimnes S, Martinsen ØG (2015) Chapter 11 - History of bioimpedance and bioelectricity.
In: Bioimpedance and bioelectricity basics, 3rd edn. Academic Press, Cambridge, pp 495–504.
https://doi.org/10.1016/B978-0-12-411470-8.00011-8
12. Sanchez B, Vandersteen G, Bragos R, Schoukens J (2011) Optimal multisine excitation design
for broadband electrical impedance spectroscopy. Meas Sci Technol 22(11):115601. https://doi.
org/10.1088/0957-0233/22/11/115601
13. Pauwels D, Pilehvar S, Geboes B, Hubin A, De Wael K, Breugelmans T (2016) A new
multisine-based impedimetric aptasensing platform. Electrochem Commun 71:23–27. https://
doi.org/10.1016/j.elecom.2016.07.010
14. Pilehvar S, Ahmad Rather J, Dardenne F, Robbens J, Blust R, de Wael K (2014) Carbon
nanotubes based electrochemical aptasensing platform for the detection of hydroxylated
polychlorinated biphenyl in human blood serum. Biosens Bioelectron 54:78–84. https://doi.
org/10.1016/j.bios.2013.10.018
15. Yoo J-S, Park S-M (2000) An electrochemical impedance measurement technique employing
Fourier transform. Anal Chem 72(9):2035–2041. https://doi.org/10.1021/ac9907540
16. Jurczakowski R, Lasia A (2004) Limitations of the potential step technique to impedance
measurements using discrete time Fourier transform. Anal Chem 76(17):5033–5038. https://
doi.org/10.1021/ac0493929
17. Lim T, Lee SY, Yang J, Hwang SY, Ahn Y (2016) Microfluidic biochips for
simple impedimetric detection of thrombin based on label-free DNA aptamers. BioChip J
11(2):109–115. https://doi.org/10.1007/s13206-016-1203-7
18. Loo AH, Bonanni A, Pumera M (2012) Impedimetric thrombin aptasensor based on chemically
modified graphenes. Nanoscale 4(1):143–147. https://doi.org/10.1039/c1nr10966a
19. Meini N, Farre C, Chaix C, Kherrat R, Dzyadevych S, Jaffrezic-Renault N (2012)
A sensitive and selective thrombin impedimetric aptasensor based on tailored aptamers
obtained by solid-phase synthesis. Sens Actuators B 166–167:715–720. https://doi.org/10.
1016/j.snb.2012.03.046
20. Miodek A, Regan EM, Bhalla N, Hopkins NA, Goodchild SA, Estrela P (2015) Optimisation
and characterisation of anti-fouling ternary SAM layers for impedance-based aptasensors.
Sensors 15(10):25015–25032. https://doi.org/10.3390/s151025015
21. Oyama N, Ohsaka T, Yamamoto N, Matsui J, Hatozaki O (1989) Determination of the heterogeneous electron-transfer rate constants for the redox couples Mo(CN)
4À/3À
8 , W(CN)
4À/3À
8 ,
Fe(CN)
4À/3À
6 , Os(CN)
4À/3À
6 and IrCl
3À/2À
6 using fast sweep cyclic voltammetry at carbon fibre
electrodes. J Electroanal Chem Interfacial Electrochem 265(1):297–304
22. Peng K, Zhao H, Xie P, Hu S, Yuan Y, Yuan R, Wu X (2016) Impedimetric aptasensor for
nuclear factor kappa B with peroxidase-like mimic coupled DNA nanoladders as enhancer.
Biosens Bioelectron 81:1–7. https://doi.org/10.1016/j.bios.2015.12.039
23. Chandrasekaran AR (2016) Designer DNA architectures: applications in nanomedicine.
Nanobiomedicine 3:6. https://doi.org/10.5772/63228
24. Sheng QL, Liu RX, Zheng JB, Zhu JJ (2013) Reversible switches of DNA nanostructures between
“Closed” and “Open” states and their biosensing applications. Nanoscale 5(16):7505–7511.
https://doi.org/10.1039/c3nr01576a
38
P. Reich et al.