71. Wu L et al (2016) A paper-based electrochemiluminescence electrode as an aptamer-based
cytosensor using PtNi@carbon dots as nanolabels for detection of cancer cells and for in-situ
screening of anticancer drugs. Microchim Acta 183(6):1873–1880
72. Zhang HR, Xia XH, Xu JJ, Chen HY (2012) Sensitive cancer cell detection based on Au
nanoparticles enhanced electrochemiluminescence of CdS nanocrystal film supplemented by
magnetic separation. Electrochem Commun 25(1):112–115
73. Tan J et al (2016) Aptamer-functionalized fluorescent silica nanoparticles for highly sensitive
detection of leukemia cells. Nanoscale Res Lett 11(1)
74. Yu M et al (2017) Dual-recognition Förster resonance energy transfer based platform for
one-step sensitive detection of pathogenic bacteria using fluorescent vancomycin-gold
nanoclusters and aptamer-gold nanoparticles. Anal Chem 89(7):4085–4090
75. Wang J et al (2015) Magnetically assisted surface-enhanced Raman spectroscopy for the
detection of Staphylococcus aureus based on aptamer recognition. ACS Appl Mater Interfaces
7(37):20919–20929
76. Pathania P, Sharma A, Kumar B, Rishi P, Raman Suri C (2017) Selective identification of
specific aptamers for the detection of non-typhoidal salmonellosis in an apta-impedimetric
sensing format. Microchim Acta 184(5):1499–1508
77. Jo H, Her J, Ban C (2015) Dual aptamer-functionalized silica nanoparticles for the highly
sensitive detection of breast cancer. Biosens Bioelectron 71:129–136
78. Dai P-P, Li J-Y, Yu T, Xu J-J, Chen H-Y (2015) Nanocrystal-based electrochemiluminescence
sensor for cell detection with Au nanoparticles and isothermal circular double-assisted signal
amplification. Talanta 141:97–102
79. Farokhzad OC, Langer R (2009) Impact of nanotechnology on drug. ACS Nano 3(1):16–20
80. Mu C et al (2013) Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for
targeted delivery to brain-derived endothelial cells in vitro. J Microencapsul 30(7):701–708
81. Farokhzad OC et al (2006) Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci 103(16):6315–6320
82. Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ (2008) Targeted delivery of cisplatin to
prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles.
Proc Natl Acad Sci 105(45):17356–17361
83. Giljohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, Mirkin CA (2010) Gold
nanoparticles for biology and medicine. Angew Chem Int Ed 49(19):3280–3294
84. Zhang L et al (2007) Co-delivery of hydrophobic and hydrophilic drugs from nanoparticleaptamer bioconjugates. ChemMedChem 2(9):1268–1271
85. Zhou J, Rossi JJ (2014) Cell-type-specific, aptamer-functionalized agents for targeted disease
therapy. Mol Ther Nucleic Acids 3:e169
86. Taghdisi SM et al (2016) Double targeting, controlled release and reversible delivery of
daunorubicin to cancer cells by polyvalent aptamers-modified gold nanoparticles. Mater Sci
Eng C 61:753–761
87. Pattni BS, Chupin VV, Torchilin VP (2015) New developments in liposomal drug delivery.
Chem Rev 115(19):10938–10966
88. Bangham AD, De Gier J, Greville GD (1967) Osmotic properties and water permeability of
phospholipid liquid crystals. Chem Phys Lipids 1(3):225–246
89. Deamer DW (1978) Preparation and properties of ether-injection liposomes. Ann N Y Acad
Sci 308(1):250–258
90. Jahn A, Vreeland WN, Gaitan M, Locascio LE (2004) Controlled vesicle self-assembly in
microfluidic channels with hydrodynamic focusing. J Am Chem Soc 126(9):2674–2675
91. Kang H, O’Donoghue MB, Liu H, Tan W (2010) A liposome-based nanostructure for aptamer
directed delivery. Chem Commun 46(2):249–251
92. Li L et al (2014) Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of
siRNA for the treatment of malignant melanomas. Biomaterials 35(12):3840–3850
93. Barenholz Y (2012) Doxil® – the first FDA-approved nano-drug: lessons learned. J Control
Release 160(2):117–134
Aptamer-Modified Nanoparticles in Medical Applications
191
cytosensor using PtNi@carbon dots as nanolabels for detection of cancer cells and for in-situ
screening of anticancer drugs. Microchim Acta 183(6):1873–1880
72. Zhang HR, Xia XH, Xu JJ, Chen HY (2012) Sensitive cancer cell detection based on Au
nanoparticles enhanced electrochemiluminescence of CdS nanocrystal film supplemented by
magnetic separation. Electrochem Commun 25(1):112–115
73. Tan J et al (2016) Aptamer-functionalized fluorescent silica nanoparticles for highly sensitive
detection of leukemia cells. Nanoscale Res Lett 11(1)
74. Yu M et al (2017) Dual-recognition Förster resonance energy transfer based platform for
one-step sensitive detection of pathogenic bacteria using fluorescent vancomycin-gold
nanoclusters and aptamer-gold nanoparticles. Anal Chem 89(7):4085–4090
75. Wang J et al (2015) Magnetically assisted surface-enhanced Raman spectroscopy for the
detection of Staphylococcus aureus based on aptamer recognition. ACS Appl Mater Interfaces
7(37):20919–20929
76. Pathania P, Sharma A, Kumar B, Rishi P, Raman Suri C (2017) Selective identification of
specific aptamers for the detection of non-typhoidal salmonellosis in an apta-impedimetric
sensing format. Microchim Acta 184(5):1499–1508
77. Jo H, Her J, Ban C (2015) Dual aptamer-functionalized silica nanoparticles for the highly
sensitive detection of breast cancer. Biosens Bioelectron 71:129–136
78. Dai P-P, Li J-Y, Yu T, Xu J-J, Chen H-Y (2015) Nanocrystal-based electrochemiluminescence
sensor for cell detection with Au nanoparticles and isothermal circular double-assisted signal
amplification. Talanta 141:97–102
79. Farokhzad OC, Langer R (2009) Impact of nanotechnology on drug. ACS Nano 3(1):16–20
80. Mu C et al (2013) Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for
targeted delivery to brain-derived endothelial cells in vitro. J Microencapsul 30(7):701–708
81. Farokhzad OC et al (2006) Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci 103(16):6315–6320
82. Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ (2008) Targeted delivery of cisplatin to
prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles.
Proc Natl Acad Sci 105(45):17356–17361
83. Giljohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, Mirkin CA (2010) Gold
nanoparticles for biology and medicine. Angew Chem Int Ed 49(19):3280–3294
84. Zhang L et al (2007) Co-delivery of hydrophobic and hydrophilic drugs from nanoparticleaptamer bioconjugates. ChemMedChem 2(9):1268–1271
85. Zhou J, Rossi JJ (2014) Cell-type-specific, aptamer-functionalized agents for targeted disease
therapy. Mol Ther Nucleic Acids 3:e169
86. Taghdisi SM et al (2016) Double targeting, controlled release and reversible delivery of
daunorubicin to cancer cells by polyvalent aptamers-modified gold nanoparticles. Mater Sci
Eng C 61:753–761
87. Pattni BS, Chupin VV, Torchilin VP (2015) New developments in liposomal drug delivery.
Chem Rev 115(19):10938–10966
88. Bangham AD, De Gier J, Greville GD (1967) Osmotic properties and water permeability of
phospholipid liquid crystals. Chem Phys Lipids 1(3):225–246
89. Deamer DW (1978) Preparation and properties of ether-injection liposomes. Ann N Y Acad
Sci 308(1):250–258
90. Jahn A, Vreeland WN, Gaitan M, Locascio LE (2004) Controlled vesicle self-assembly in
microfluidic channels with hydrodynamic focusing. J Am Chem Soc 126(9):2674–2675
91. Kang H, O’Donoghue MB, Liu H, Tan W (2010) A liposome-based nanostructure for aptamer
directed delivery. Chem Commun 46(2):249–251
92. Li L et al (2014) Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of
siRNA for the treatment of malignant melanomas. Biomaterials 35(12):3840–3850
93. Barenholz Y (2012) Doxil® – the first FDA-approved nano-drug: lessons learned. J Control
Release 160(2):117–134
Aptamer-Modified Nanoparticles in Medical Applications
191