49. Liu J, Bai W, Niu S, Zhu C, Yang S, Chen A (2014) Highly sensitive colorimetric detection of
17b-estradiol using split DNA aptamers immobilized on unmodified gold nanoparticles. Sci
Rep 4:7571
50. Rafati A, Zarrabi A, Abediankenari S, Aarabi M, Gill P (2018) Sensitive colorimetric assay
using insulin g-quadruplex aptamer arrays on DNA nanotubes coupled with magnetic
nanoparticles. R Soc Open Sci 5(3)
51. Chávez JL, Hagen JA, Kelley-Loughnane N (2017) Fast and selective plasmonic serotonin
detection with aptamer-gold nanoparticle conjugates. Sensors (Switzerland) 17(4)
52. Kang KA, Wang J, Jasinski JB, Achilefu S (2011) Fluorescence manipulation by gold
nanoparticles: from complete quenching to extensive enhancement. J Nanobiotechnol 9:1–13
53. Wang RE, Zhang Y, Cai J, Cai W, Gao T (2011) Aptamer-based fluorescent biosensors. Curr
Med Chem 18(27):4175–4184
54. Musumeci D et al (2017) Fluorescence sensing using DNA aptamers in cancer research and
clinical diagnostics. Cancers (Basel) 9(12):174
55. Zhang C-Y, Johnson LW (2009) Single quantum-dot-based aptameric nanosensor for cocaine.
Anal Chem 81(8):3051–3055
56. Rezaei Z, Ranjbar B (2017) Ultra-sensitive, rapid gold nanoparticle-quantum dot plexcitonic
self-assembled aptamer-based nanobiosensor for the detection of human cardiac troponin
I. Eng Life Sci 17(2):165–174
57. Nanotech O et al (2009) Aptamer-based detection of epithelial tumor marker mucin 1 with
quantum dot-based fluorescence readout. Biochem Biophys Res Commun 57(2):6130–6139
58. Zhu D et al (2015) Silver nanoparticles-enhanced time-resolved fluorescence sensor for VEGF
165 based on Mn-doped ZnS quantum dots. Biosens Bioelectron 74:1053–1060
59. Jiang H, Ling K, Tao X, Zhang Q (2015) Theophylline detection in serum using a selfassembling RNA aptamer-based gold nanoparticle sensor. Biosens Bioelectron 70:299–303
60. Pang Y, Rong Z, Wang J, Xiao R, Wang S (2015) A fluorescent aptasensor for H5N1 influenza
virus detection based-on the core–shell nanoparticles metal-enhanced fluorescence (MEF).
Biosens Bioelectron 66:527–532
61. Kim T, Lee C-H, Joo S-W, Lee K (2008) Kinetics of gold nanoparticle aggregation: experiments and modeling. J Colloid Interface Sci 318:238–243
62. Mao J, Xu M, Ji W, Zhang M (2018) Absorbance enhancement of aptamers/GNP enables
sensitive protein detection in rat brains. Chem Commun 54(10):1193–1196
63. Panczyk T, Konczak L, Zapotoczny S, Szabelski P, Nowakowska M (2015) Molecular
dynamics simulations of proton transverse relaxation times in suspensions of magnetic
nanoparticles. J Colloid Interface Sci 437:187–196
64. Bamrungsap S, Shukoor MI, Chen T, Sefah K, Tan W (2011) Detection of lysozyme magnetic
relaxation switches based on aptamer-functionalized superparamagnetic nanoparticles. Anal
Chem 83(20):7795–7799
65. Wei B, Mao K, Liu N, Zhang M, Yang Z (2018) Graphene nanocomposites modified
electrochemical aptamer sensor for rapid and highly sensitive detection of prostate specific
antigen. Biosens Bioelectron 121:41–46
66. Eissa S, Zourob M (2017) Aptamer-based label-free electrochemical biosensor array for the
detection of total and glycated hemoglobin in human whole blood. Sci Rep 7(1):1016
67. Selvolini G et al (2018) DNA-based sensor for the detection of an organophosphorus pesticide:
profenofos. Sensors 18(7):2035
68. Mir TA, Yoon JH, Gurudatt NG, Won MS, Shim YB (2015) Ultrasensitive cytosensing based
on an aptamer modified nanobiosensor with a bioconjugate: detection of human non-small-cell
lung cancer cells. Biosens Bioelectron 74:594–600
69. Zhu Y, Chandra P, Shim YB (2013) Ultrasensitive and selective electrochemical diagnosis of
breast cancer based on a hydrazine-Au nanoparticle-aptamer bioconjugate. Anal Chem 85
(2):1058–1064
70. Huang YF, Lin YW, Lin ZH, Chang HT (2009) Aptamer-modified gold nanoparticles for
targeting breast cancer cells through light scattering. J Nanopart Res 11(4):775–783
190
A. Eilers et al.
17b-estradiol using split DNA aptamers immobilized on unmodified gold nanoparticles. Sci
Rep 4:7571
50. Rafati A, Zarrabi A, Abediankenari S, Aarabi M, Gill P (2018) Sensitive colorimetric assay
using insulin g-quadruplex aptamer arrays on DNA nanotubes coupled with magnetic
nanoparticles. R Soc Open Sci 5(3)
51. Chávez JL, Hagen JA, Kelley-Loughnane N (2017) Fast and selective plasmonic serotonin
detection with aptamer-gold nanoparticle conjugates. Sensors (Switzerland) 17(4)
52. Kang KA, Wang J, Jasinski JB, Achilefu S (2011) Fluorescence manipulation by gold
nanoparticles: from complete quenching to extensive enhancement. J Nanobiotechnol 9:1–13
53. Wang RE, Zhang Y, Cai J, Cai W, Gao T (2011) Aptamer-based fluorescent biosensors. Curr
Med Chem 18(27):4175–4184
54. Musumeci D et al (2017) Fluorescence sensing using DNA aptamers in cancer research and
clinical diagnostics. Cancers (Basel) 9(12):174
55. Zhang C-Y, Johnson LW (2009) Single quantum-dot-based aptameric nanosensor for cocaine.
Anal Chem 81(8):3051–3055
56. Rezaei Z, Ranjbar B (2017) Ultra-sensitive, rapid gold nanoparticle-quantum dot plexcitonic
self-assembled aptamer-based nanobiosensor for the detection of human cardiac troponin
I. Eng Life Sci 17(2):165–174
57. Nanotech O et al (2009) Aptamer-based detection of epithelial tumor marker mucin 1 with
quantum dot-based fluorescence readout. Biochem Biophys Res Commun 57(2):6130–6139
58. Zhu D et al (2015) Silver nanoparticles-enhanced time-resolved fluorescence sensor for VEGF
165 based on Mn-doped ZnS quantum dots. Biosens Bioelectron 74:1053–1060
59. Jiang H, Ling K, Tao X, Zhang Q (2015) Theophylline detection in serum using a selfassembling RNA aptamer-based gold nanoparticle sensor. Biosens Bioelectron 70:299–303
60. Pang Y, Rong Z, Wang J, Xiao R, Wang S (2015) A fluorescent aptasensor for H5N1 influenza
virus detection based-on the core–shell nanoparticles metal-enhanced fluorescence (MEF).
Biosens Bioelectron 66:527–532
61. Kim T, Lee C-H, Joo S-W, Lee K (2008) Kinetics of gold nanoparticle aggregation: experiments and modeling. J Colloid Interface Sci 318:238–243
62. Mao J, Xu M, Ji W, Zhang M (2018) Absorbance enhancement of aptamers/GNP enables
sensitive protein detection in rat brains. Chem Commun 54(10):1193–1196
63. Panczyk T, Konczak L, Zapotoczny S, Szabelski P, Nowakowska M (2015) Molecular
dynamics simulations of proton transverse relaxation times in suspensions of magnetic
nanoparticles. J Colloid Interface Sci 437:187–196
64. Bamrungsap S, Shukoor MI, Chen T, Sefah K, Tan W (2011) Detection of lysozyme magnetic
relaxation switches based on aptamer-functionalized superparamagnetic nanoparticles. Anal
Chem 83(20):7795–7799
65. Wei B, Mao K, Liu N, Zhang M, Yang Z (2018) Graphene nanocomposites modified
electrochemical aptamer sensor for rapid and highly sensitive detection of prostate specific
antigen. Biosens Bioelectron 121:41–46
66. Eissa S, Zourob M (2017) Aptamer-based label-free electrochemical biosensor array for the
detection of total and glycated hemoglobin in human whole blood. Sci Rep 7(1):1016
67. Selvolini G et al (2018) DNA-based sensor for the detection of an organophosphorus pesticide:
profenofos. Sensors 18(7):2035
68. Mir TA, Yoon JH, Gurudatt NG, Won MS, Shim YB (2015) Ultrasensitive cytosensing based
on an aptamer modified nanobiosensor with a bioconjugate: detection of human non-small-cell
lung cancer cells. Biosens Bioelectron 74:594–600
69. Zhu Y, Chandra P, Shim YB (2013) Ultrasensitive and selective electrochemical diagnosis of
breast cancer based on a hydrazine-Au nanoparticle-aptamer bioconjugate. Anal Chem 85
(2):1058–1064
70. Huang YF, Lin YW, Lin ZH, Chang HT (2009) Aptamer-modified gold nanoparticles for
targeting breast cancer cells through light scattering. J Nanopart Res 11(4):775–783
190
A. Eilers et al.