97. Modh H, Scheper T, Walter JG (2018) Aptamer-modified magnetic beads in biosensing.
Sensors 18:e1041
98. He F, Wen N, Xiao D, Yan J, Xiong H, Cai S, Liu Z, Liu Y (2019) Aptamer based targeted
drug delivery systems: current potential and challenges. Curr Med Chem. https://doi.org/10.
2174/0929867325666181008142831
99. Wermuth PJ, Piera-Velazquez S, Jimenez SA (2018) Identification of novel systemic sclerosis
biomarkers employing aptamer proteomic analysis. Rheumatology 57:1698–1706
100. Xu L, Zhang Z, Zhang Q, Li P (2016) Mycotoxin determination in foods using advanced
sensors based on antibodies or aptamers. Toxins 8:e239
101. Jin C, Zheng J, Li C, Qiu L, Zhang X, Tan W (2015) Aptamers selected by cell-SELEX for
molecular imaging. J Mol Evol 81:162–171
102. Flamm C, Fontana W, Hofacker IL, Schuster P (2000) RNA folding at elementary step
resolution. RNA 6:325–338
103. Tang X, Thomas S, Tapia L, Giedroc DP, Amato NM (2008) Simulating RNA folding kinetics
on approximated energy landscapes. J Mol Biol 38:1055–1067
104. Fallmann J, Will S, Engelhardt J, Grüning B, Backofen R, Stadler PF (2017) Recent advances
in RNA folding. J Biotechnol 261:97–104
105. Li Y, Breaker RR (1999) Kinetics of RNA degradation by specific base catalysis of
transesterification involving the 2¢-hydroxyl group. J Am Chem Soc 121:5364–5372
106. Keefe AD, Cload ST (2008) SELEX with modified nucleotides. Curr Opin Chem Biol
12:448–456
107. Burmeister PE, Lewis SD, Silva RF, Horwitz LR, Pendergrast PS, McCauley TG, Kurz JC,
Epstein DM, Wilson C, Keefe AD (2005) Direct in vitro selection of a 2’-O-methyl aptamer to
VEGF. Chem Biol 12:25–33
108. Vaught JD, Bock C, Carter J, Fitzwater T, Otis M, Schneider D, Rolando J, Waugh S, Wilcox
SK, Eaton BE (2010) Expanding the chemistry of DNA for in vitro selection. J Am Chem Soc
132:4141–4151
109. Veedu RN, Vester B, Wengel J (2008) Polymerase chain reaction and transcription using
locked nucleic acid nucleotide triphosphates. J Am Chem Soc 130:8124–8125
110. Inomata E, Tashiro E, Miyakawa S, Nakamura Y, Akita K (2018) Alkaline-tolerant RNA
aptamers useful to purify acid-sensitive antibodies in neutral conditions. Biochimie
145:113–124
111. Tolle F, Brändle GM, Matzner D, Mayer G (2015) A versatile approach towards nucleobasemodified aptamers. Angew Chem Int Ed Engl 54:10971–10974
112. Perret G, Boschetti E (2018) Aptamer affinity ligands in protein chromatography. Biochimie
145:98–112
113. Urh M, Simpson D, Zhao K (2009) Affinity chromatography: general methods. Methods
Enzymol 463:417–438
114. Hage DS (2000) Periodate oxidation of antibodies for site-selective immobilization in
immunoaffinity chromatography. Methods Mol Biol 147:69–82
115. Balamurugan S, Obubuafo A, Soper SA, Spivak DA (2008) Surface immobilization methods
for aptamer diagnostic applications. Anal Bioanal Chem 390:1009–1021
116. Walter JG, Stahl F, Scheper T (2012) Aptamers as affinity ligands for downstream processing.
Eng Life Sci 12:1–11
117. Labrou N, Clonis YD (1994) The affinity technology in downstream processing. J Biotechnol
36:95–119
118. Deng Q, German I, Buchanan D, Kennedy RT (2001) Retention and separation of adenosine
and analogues by affinity chromatography with an aptamer stationary phase. Anal Chem
73:5415–5421
119. Murphy MB, Fuller ST, Richardson PM, Doyle SA (2003) An improved method for the
in vitro evolution of aptamers and applications in protein detection and purification. Nucleic
Acids Res 31:e110
120. Michaud M, Jourdan E, Villet A, Ravel A, Grosset C, Peyrin E (2003) A DNA aptamer as a
new target-specific chiral selector for HPLC. J Am Chem Soc 125:8672–8679
Aptamer-Based Affinity Chromatography for Protein Extraction and Purification
135
Sensors 18:e1041
98. He F, Wen N, Xiao D, Yan J, Xiong H, Cai S, Liu Z, Liu Y (2019) Aptamer based targeted
drug delivery systems: current potential and challenges. Curr Med Chem. https://doi.org/10.
2174/0929867325666181008142831
99. Wermuth PJ, Piera-Velazquez S, Jimenez SA (2018) Identification of novel systemic sclerosis
biomarkers employing aptamer proteomic analysis. Rheumatology 57:1698–1706
100. Xu L, Zhang Z, Zhang Q, Li P (2016) Mycotoxin determination in foods using advanced
sensors based on antibodies or aptamers. Toxins 8:e239
101. Jin C, Zheng J, Li C, Qiu L, Zhang X, Tan W (2015) Aptamers selected by cell-SELEX for
molecular imaging. J Mol Evol 81:162–171
102. Flamm C, Fontana W, Hofacker IL, Schuster P (2000) RNA folding at elementary step
resolution. RNA 6:325–338
103. Tang X, Thomas S, Tapia L, Giedroc DP, Amato NM (2008) Simulating RNA folding kinetics
on approximated energy landscapes. J Mol Biol 38:1055–1067
104. Fallmann J, Will S, Engelhardt J, Grüning B, Backofen R, Stadler PF (2017) Recent advances
in RNA folding. J Biotechnol 261:97–104
105. Li Y, Breaker RR (1999) Kinetics of RNA degradation by specific base catalysis of
transesterification involving the 2¢-hydroxyl group. J Am Chem Soc 121:5364–5372
106. Keefe AD, Cload ST (2008) SELEX with modified nucleotides. Curr Opin Chem Biol
12:448–456
107. Burmeister PE, Lewis SD, Silva RF, Horwitz LR, Pendergrast PS, McCauley TG, Kurz JC,
Epstein DM, Wilson C, Keefe AD (2005) Direct in vitro selection of a 2’-O-methyl aptamer to
VEGF. Chem Biol 12:25–33
108. Vaught JD, Bock C, Carter J, Fitzwater T, Otis M, Schneider D, Rolando J, Waugh S, Wilcox
SK, Eaton BE (2010) Expanding the chemistry of DNA for in vitro selection. J Am Chem Soc
132:4141–4151
109. Veedu RN, Vester B, Wengel J (2008) Polymerase chain reaction and transcription using
locked nucleic acid nucleotide triphosphates. J Am Chem Soc 130:8124–8125
110. Inomata E, Tashiro E, Miyakawa S, Nakamura Y, Akita K (2018) Alkaline-tolerant RNA
aptamers useful to purify acid-sensitive antibodies in neutral conditions. Biochimie
145:113–124
111. Tolle F, Brändle GM, Matzner D, Mayer G (2015) A versatile approach towards nucleobasemodified aptamers. Angew Chem Int Ed Engl 54:10971–10974
112. Perret G, Boschetti E (2018) Aptamer affinity ligands in protein chromatography. Biochimie
145:98–112
113. Urh M, Simpson D, Zhao K (2009) Affinity chromatography: general methods. Methods
Enzymol 463:417–438
114. Hage DS (2000) Periodate oxidation of antibodies for site-selective immobilization in
immunoaffinity chromatography. Methods Mol Biol 147:69–82
115. Balamurugan S, Obubuafo A, Soper SA, Spivak DA (2008) Surface immobilization methods
for aptamer diagnostic applications. Anal Bioanal Chem 390:1009–1021
116. Walter JG, Stahl F, Scheper T (2012) Aptamers as affinity ligands for downstream processing.
Eng Life Sci 12:1–11
117. Labrou N, Clonis YD (1994) The affinity technology in downstream processing. J Biotechnol
36:95–119
118. Deng Q, German I, Buchanan D, Kennedy RT (2001) Retention and separation of adenosine
and analogues by affinity chromatography with an aptamer stationary phase. Anal Chem
73:5415–5421
119. Murphy MB, Fuller ST, Richardson PM, Doyle SA (2003) An improved method for the
in vitro evolution of aptamers and applications in protein detection and purification. Nucleic
Acids Res 31:e110
120. Michaud M, Jourdan E, Villet A, Ravel A, Grosset C, Peyrin E (2003) A DNA aptamer as a
new target-specific chiral selector for HPLC. J Am Chem Soc 125:8672–8679
Aptamer-Based Affinity Chromatography for Protein Extraction and Purification
135