9 Natural Selection, Genetic Variation, and Human Diversity
215
Table 9.1
Studies of identifying genomic regions under selection using genome-wide scans
Study
Data
Statistic
Population(s)
# Candidates found Candidate regions of note
1000 Genomes
Project Consortium
(2010)
Low coverage whole
genomes
Population
differentiation (F
ST )
3 HapMap II
152 genes
SLC24A5
DARC
EDAR
SLC45A2
PCDH15
HERC1
ALMS1
Akey et al. (2002)
26.5 K SNPs
Population
differentiation (F
ST )
European-American
African-American
Chinese-American
(The SNP Consortium)
174 regions
CFTR
APOB
Amato et al. (2009)
4 M SNPs
(HapMap III)
Population
differentiation (F
ST )
3 HapMap II
Bhatia et al. (2011)
250 K or 900 K SNPs
(imputed to 900 K for
all)
Population
differentiation (F
ST )
Gambian
African-American
Nigerian
LCT
HBB
HLA
Cai et al. (2011)
4 M SNPs
(HapMap II)
Shared genomic segment
(SGS)
(homozygosity tracts)
3 HapMap II
20 regions
Chen et al. (2010)
3.6 M SNPs
XP-CLR (differentiation) 3 HapMap II
N. and S. Europeans
from POPRES
40 regions
LCT
HERC2
Grossman et al.
(2010)
3.1 M SNPs
CMS based on FST
xp-EHH, delta-iHH,
delta-DAF, and iHS
3 HapMap II
Tested only 185
candidate regions
from past scans
MATP
LCT
EDAR
HERC2
SLC24A5
PCDH15
(continued)