182
B. F. Voight
Rabbee N, Speed TP (2005) A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics 22:7–12
Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, International Schizophrenia Consortium, Purcell
SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ (2009) Identifying relationships
among genomic disease regions: predicting genes at pathogenic SNP associations and rare
deletions. PLoS Genet 5:e1000534
Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science
273:1516–1517
Rosenberg NA, Huang L, Jewett EM, Szpiech ZA, Jankovic I, Boehnke M (2010) Genome-wide
association studies in diverse populations. Nat Rev Genet 11:356–366
Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, International Inflammatory
Bowel Disease Genetics Consortium, Cotsapas C, Daly MJ (2011) Proteins encoded in genomic
regions associated with immune-mediated disease physically interact and suggest underlying
biology. PLoS Genet 7:e1001273
Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA,
Li YR et al (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2
diabetes loci. Am J Hum Genet 90:410–425
Schork NJ, Murray SS, Frazer KA, Topol EJ (2009) Common vs. rare allele hypotheses for
complex diseases. Curr Opin Genet Dev 19:212–219
SEARCH Collaborative Group, Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, Gut
I, Lathrop M, Collins R (2008) SLCO1B1 variants and statin-induced myopathy–a genomewide
study. N Engl J Med 359:789–799
Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB,
Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT (2011) Retraction. Science
333:404
Segrè AV, DIAGRAM Consortium, MAGIC investigators, Groop L, Mootha VK, Daly MJ,
Altshuler D (2010) Common inherited variation in mitochondrial genes is not enriched for
associations with type 2 diabetes or related glycemic traits. PLoS Genet 6:e1001058
SIGMA Type 2 Diabetes Consortium (2013) Sequence variants in SLC16A11 are a common risk
factor for type 2 diabetes in Mexico. Nature 506:97–101
Simons YB, Turchin MC, Pritchard JK, Sella G (2014) The deleterious mutation load is insensitive
to recent population history. Nat Genet 46(3):220–224
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL,
Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung
HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta
JL, Nóbrega MA (2014) Obesity-associated variants within FTO form long-range functional
connections with IRX3. Nature 507(7492):371–375
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren
CM, Luan J, Magi R, Randall JC et al (2010) Association analyses of 249,796 individuals reveal
18 new loci associated with body mass index. Nat Genet 42:937–948
Tenesa A, Haley CS (2013) The heritability of human disease: estimation, uses and abuses. Nat
Rev Genet 14:139–149
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP,
Ripatti S, Chasman DI, Willer CJ, Johansen CT et al (2010) Biological, clinical and population
relevance of 95 loci for blood lipids. Nature 466:707–713
The Diabetes Genetics Initiative (2007) Genome-wide association analysis identifies loci for type
2 diabetes and triglyceride levels. Science 316:1331–1336
Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, BhawRosun L, Castillejo G, de la Concha, et al. (2011) Dense genotyping identifies and localizes
multiple common and rare variant association signals in celiac disease. Nat Genet 43:1193–
1201
Visscher PM, Brown MA, McCarthy MI, Yang J (2012) Five years of GWAS discovery. Am J Hum
Genet 90:7–24
B. F. Voight
Rabbee N, Speed TP (2005) A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics 22:7–12
Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, International Schizophrenia Consortium, Purcell
SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ (2009) Identifying relationships
among genomic disease regions: predicting genes at pathogenic SNP associations and rare
deletions. PLoS Genet 5:e1000534
Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science
273:1516–1517
Rosenberg NA, Huang L, Jewett EM, Szpiech ZA, Jankovic I, Boehnke M (2010) Genome-wide
association studies in diverse populations. Nat Rev Genet 11:356–366
Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, International Inflammatory
Bowel Disease Genetics Consortium, Cotsapas C, Daly MJ (2011) Proteins encoded in genomic
regions associated with immune-mediated disease physically interact and suggest underlying
biology. PLoS Genet 7:e1001273
Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA,
Li YR et al (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2
diabetes loci. Am J Hum Genet 90:410–425
Schork NJ, Murray SS, Frazer KA, Topol EJ (2009) Common vs. rare allele hypotheses for
complex diseases. Curr Opin Genet Dev 19:212–219
SEARCH Collaborative Group, Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, Gut
I, Lathrop M, Collins R (2008) SLCO1B1 variants and statin-induced myopathy–a genomewide
study. N Engl J Med 359:789–799
Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB,
Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT (2011) Retraction. Science
333:404
Segrè AV, DIAGRAM Consortium, MAGIC investigators, Groop L, Mootha VK, Daly MJ,
Altshuler D (2010) Common inherited variation in mitochondrial genes is not enriched for
associations with type 2 diabetes or related glycemic traits. PLoS Genet 6:e1001058
SIGMA Type 2 Diabetes Consortium (2013) Sequence variants in SLC16A11 are a common risk
factor for type 2 diabetes in Mexico. Nature 506:97–101
Simons YB, Turchin MC, Pritchard JK, Sella G (2014) The deleterious mutation load is insensitive
to recent population history. Nat Genet 46(3):220–224
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL,
Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung
HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta
JL, Nóbrega MA (2014) Obesity-associated variants within FTO form long-range functional
connections with IRX3. Nature 507(7492):371–375
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren
CM, Luan J, Magi R, Randall JC et al (2010) Association analyses of 249,796 individuals reveal
18 new loci associated with body mass index. Nat Genet 42:937–948
Tenesa A, Haley CS (2013) The heritability of human disease: estimation, uses and abuses. Nat
Rev Genet 14:139–149
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP,
Ripatti S, Chasman DI, Willer CJ, Johansen CT et al (2010) Biological, clinical and population
relevance of 95 loci for blood lipids. Nature 466:707–713
The Diabetes Genetics Initiative (2007) Genome-wide association analysis identifies loci for type
2 diabetes and triglyceride levels. Science 316:1331–1336
Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, BhawRosun L, Castillejo G, de la Concha, et al. (2011) Dense genotyping identifies and localizes
multiple common and rare variant association signals in celiac disease. Nat Genet 43:1193–
1201
Visscher PM, Brown MA, McCarthy MI, Yang J (2012) Five years of GWAS discovery. Am J Hum
Genet 90:7–24