Nacional de Visualización Científica Avanzada from the National Autonomous University of
Mexico, and Alejandra Castillo, Carina Díaz, Abigayl Hernández and Eglee Lomelin of the International Laboratory for Human Genome Research, UNAM.
References
1. Sondka Z, Bamford S, Cole CG, Ward SA, Dunham I, Forbes SA. The COSMIC cancer gene
census: describing genetic dysfunction across all human cancers. Nat Rev Cancer. 2018;18
(11):696–705.
2. The International Agency for Research on Cancer (IARC). Latest global cancer data: Cancer
burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018. p. https://www.who.
int/cancer/PRGlobocanFinal.pdf.
3. Campbell PM, Der CJ. Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin
Cancer Biol. 2004;14(2):105–14.
4. Liu Y, Sun J, Zhao M. ONGene: a literature-based database for human oncogenes. J Genet
Genomics. 2017;44(2):119–21.
5. Gormally E, Vineis P, Matullo G, Veglia F, Caboux E, Le Roux E, et al. TP53 and KRAS2
mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective
study. Cancer Res. 2006;66(13):6871–6.
6. Pérez-Palma E, Gramm M, Nürnberg P, May P, Lal D. Simple ClinVar: an interactive web server
to explore and retrieve gene and disease variants aggregated in ClinVar database. Nucleic Acids
Res. 2019;47(W1):W99–105.
7. Chen M, Zhao H. Next-generation sequencing in liquid biopsy: cancer screening and early
detection. Hum Genomics. 2019;13(1):34.
8. Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Ng AW, Wu Y, et al. The repertoire of
mutational signatures in human cancer. bioRxiv. 2019:322859.
9. Maura F, Degasperi A, Nadeu F, Leongamornlert D, Davies H, Moore L, et al. A practical guide
for mutational signature analysis in hematological malignancies. Nat Commun. 2019;10(1):2969.
10. Hoang ML, Chen C-H, Sidorenko VS, He J, Dickman KG, Yun BH, et al. Mutational signature of
aristolochic acid exposure as revealed by whole-exome sequencing. Sci Transl Med. 2013;5
(197):197ra102.
11. Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC, Grossmann S, et al. Characterizing
mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis. Cell.
2019;176(6):1282–1294.e20.
12. Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, KRM S,
Ozenberger BA, et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet.
2013;45(10):1113–20.
13. Lucey BP, Nelson-Rees WA, Hutchins GM. Henrietta Lacks, HeLa cells, and cell culture
contamination. Arch Pathol Lab Med. 2009;133(9):1463–7.
14. Puck TT, Marcus PI. Action of x-rays on mammalian cells. J Exp Med. 1956;103(5):653–66.
15. Dutil J, Chen Z, Monteiro AN, Teer JK, Eschrich SA. An interactive resource to probe genetic
diversity and estimated ancestry in cancer cell lines. Cancer Res. 2019;79(7):1263–73.
16. Drost J, Clevers H. Organoids in cancer research. Nat Rev Cancer. 2018;18(7):407–18.
17. Organoid | Definition of Organoid by Lexico [Internet]. [cited 2019 Dec 19]. Retrieved from:
https://www.lexico.com/en/definition/organoid.
18. van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, et al. Prospective
derivation of a living organoid biobank of colorectal cancer patients. Cell. 2015;161(4):933–45.
36
C. Molina-Aguilar et al.
Mexico, and Alejandra Castillo, Carina Díaz, Abigayl Hernández and Eglee Lomelin of the International Laboratory for Human Genome Research, UNAM.
References
1. Sondka Z, Bamford S, Cole CG, Ward SA, Dunham I, Forbes SA. The COSMIC cancer gene
census: describing genetic dysfunction across all human cancers. Nat Rev Cancer. 2018;18
(11):696–705.
2. The International Agency for Research on Cancer (IARC). Latest global cancer data: Cancer
burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018. p. https://www.who.
int/cancer/PRGlobocanFinal.pdf.
3. Campbell PM, Der CJ. Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin
Cancer Biol. 2004;14(2):105–14.
4. Liu Y, Sun J, Zhao M. ONGene: a literature-based database for human oncogenes. J Genet
Genomics. 2017;44(2):119–21.
5. Gormally E, Vineis P, Matullo G, Veglia F, Caboux E, Le Roux E, et al. TP53 and KRAS2
mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective
study. Cancer Res. 2006;66(13):6871–6.
6. Pérez-Palma E, Gramm M, Nürnberg P, May P, Lal D. Simple ClinVar: an interactive web server
to explore and retrieve gene and disease variants aggregated in ClinVar database. Nucleic Acids
Res. 2019;47(W1):W99–105.
7. Chen M, Zhao H. Next-generation sequencing in liquid biopsy: cancer screening and early
detection. Hum Genomics. 2019;13(1):34.
8. Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Ng AW, Wu Y, et al. The repertoire of
mutational signatures in human cancer. bioRxiv. 2019:322859.
9. Maura F, Degasperi A, Nadeu F, Leongamornlert D, Davies H, Moore L, et al. A practical guide
for mutational signature analysis in hematological malignancies. Nat Commun. 2019;10(1):2969.
10. Hoang ML, Chen C-H, Sidorenko VS, He J, Dickman KG, Yun BH, et al. Mutational signature of
aristolochic acid exposure as revealed by whole-exome sequencing. Sci Transl Med. 2013;5
(197):197ra102.
11. Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC, Grossmann S, et al. Characterizing
mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis. Cell.
2019;176(6):1282–1294.e20.
12. Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, KRM S,
Ozenberger BA, et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet.
2013;45(10):1113–20.
13. Lucey BP, Nelson-Rees WA, Hutchins GM. Henrietta Lacks, HeLa cells, and cell culture
contamination. Arch Pathol Lab Med. 2009;133(9):1463–7.
14. Puck TT, Marcus PI. Action of x-rays on mammalian cells. J Exp Med. 1956;103(5):653–66.
15. Dutil J, Chen Z, Monteiro AN, Teer JK, Eschrich SA. An interactive resource to probe genetic
diversity and estimated ancestry in cancer cell lines. Cancer Res. 2019;79(7):1263–73.
16. Drost J, Clevers H. Organoids in cancer research. Nat Rev Cancer. 2018;18(7):407–18.
17. Organoid | Definition of Organoid by Lexico [Internet]. [cited 2019 Dec 19]. Retrieved from:
https://www.lexico.com/en/definition/organoid.
18. van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, et al. Prospective
derivation of a living organoid biobank of colorectal cancer patients. Cell. 2015;161(4):933–45.
36
C. Molina-Aguilar et al.