Puchta H (2016) Using CRISPR/Cas in three dimensions: towards synthetic plant genomes,
transcriptomes and epigenomes. Plant J 87:5–15
Radwan MM, Ross SA, Slade D, Ahmed SA, Zulfiqar F, Elsohly MA (2008) Isolation and
characterization of new Cannabis constituents from a high potency variety. Planta Med
74:267–272
Ranjan R, Dey N (2012) Development of vascular tissue and stress inducible hybrid-synthetic
promoters through dof-1 motifs rearrangement. Cell Biochem Biophys 63(3):235–245
Ravikumar S, Baylon MG, Park SJ, Choi J-I (2017) Engineered microbial biosensors based on
bacterial two-component systems as synthetic biotechnology platforms in bioremediation and
biorefinery. Microb Cell Factories 16:62
Ray DK, Mueller ND, West PC, Foley JA (2013) Yield trends are insufficient to double global crop
production by 2050. PLoS One 8:e66428
Razmi A, Golestanipour A, Nikkhah M, Bagheri A, Shamsbakhsh M, Malekzadeh-Shafaroudi S
(2019) Localized surface plasmon resonance biosensing of tomato yellow leaf curl virus. J Virol
Methods 267(267):1–7
Reed JW, Hudlicky T (2015) The quest for a practical synthesis of morphine alkaloids and their
derivatives by chemoenzymatic methods. Acc Chem Res 48:674–687
Reski R, Parsons J, Decker EL (2015) Moss-made pharmaceuticals: from bench to bedside. Plant
Biotechnol J 13(8):1191–1198
Reski R, Bae H, Simonsen HT (2018) Physcomitrella patens, a versatile synthetic biology chassis.
Plant Cell Rep 37:1409–1417
Richardson SM, Mitchell LA, Stracquadanio G, Yang K, Dymond JS, DiCarlo JE, Lee D, Huang
CLV, Chandrasegaran S, Cai Y, Boeke JD, Bader JS (2017) Design of a synthetic yeast genome.
Science 355:1040–1044
Ricroch A, Clairand P, Harwood W (2017) Use of CRISPR systems in plant genome editing:
toward new opportunities in agriculture. Emerg Top Life Sci 1(2):169–182
Ro D-K, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham
TS, Kirby J, Chang MCY, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of
the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940–943
Roell M-S, Zurbriggen MD (2020) The impact of synthetic biology for future agriculture and
nutrition. Curr Opin Biotech 61:102–109
Rogers C, Oldroyd GED (2014) Synthetic biology approaches to engineering the nitrogen symbiosis in cereals. J Exp Bot 65(8):1939–1946
Rorrer NA, Dorgan JR, Vardon DR, Martinez CR, Yang Y, Beckham GT (2016) Renewable
unsaturated polyesters from muconic acid. ACS Sustain Chem Eng 4:6867–6876
Roy SJ, Negrão S, Tester M (2014) Salt resistant crop plants. Curr Opin Biotechnol 26:115–124
Ruiz-Lopez N, Haslam RP, Napier JA, Sayanova O (2014) Successful high-level accumulation of
fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. Plant J
77:198–208
Ryu MH, Zhang J, Toth T, Khokhani D, Geddes BA, Mus F, Garcia-Costas A, Peters JW, Poole PS,
Ané J-M, Voigt CA (2020) Control of nitrogen fixation in bacteria that associate with cereals.
Nat Microbiol 5(2):314–330
Sánchez-León S, Gil-Humanes J, Ozuna CV, Giménez MJ, Sousa C, Voytas DF, Barro F (2018)
Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9. Plant Biotechnol J 16
(4):902–910
Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De Rosa M, Stefanile R,
Mazzarella G, Tolone C, Russo MI, Esposito P, Ferraraccio F, Cartenì M, Riegler G, de
Magistris L, Fasano A (2011) Divergence of gut permeability and mucosal immune gene
expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC
Med 9:23
Sarrrion-Perdigones A, Vazquez-Vilar M, Palaci J, Castelijns B, Forment J, Ziarsolo P, Blanca J,
Granell A, Orzaez D (2013) GoldenBraid 2.0: a comprehensive DNA assembly framework for
plant synthetic biology. Plant Physiol 162:1618–1631
484
P. Singla
transcriptomes and epigenomes. Plant J 87:5–15
Radwan MM, Ross SA, Slade D, Ahmed SA, Zulfiqar F, Elsohly MA (2008) Isolation and
characterization of new Cannabis constituents from a high potency variety. Planta Med
74:267–272
Ranjan R, Dey N (2012) Development of vascular tissue and stress inducible hybrid-synthetic
promoters through dof-1 motifs rearrangement. Cell Biochem Biophys 63(3):235–245
Ravikumar S, Baylon MG, Park SJ, Choi J-I (2017) Engineered microbial biosensors based on
bacterial two-component systems as synthetic biotechnology platforms in bioremediation and
biorefinery. Microb Cell Factories 16:62
Ray DK, Mueller ND, West PC, Foley JA (2013) Yield trends are insufficient to double global crop
production by 2050. PLoS One 8:e66428
Razmi A, Golestanipour A, Nikkhah M, Bagheri A, Shamsbakhsh M, Malekzadeh-Shafaroudi S
(2019) Localized surface plasmon resonance biosensing of tomato yellow leaf curl virus. J Virol
Methods 267(267):1–7
Reed JW, Hudlicky T (2015) The quest for a practical synthesis of morphine alkaloids and their
derivatives by chemoenzymatic methods. Acc Chem Res 48:674–687
Reski R, Parsons J, Decker EL (2015) Moss-made pharmaceuticals: from bench to bedside. Plant
Biotechnol J 13(8):1191–1198
Reski R, Bae H, Simonsen HT (2018) Physcomitrella patens, a versatile synthetic biology chassis.
Plant Cell Rep 37:1409–1417
Richardson SM, Mitchell LA, Stracquadanio G, Yang K, Dymond JS, DiCarlo JE, Lee D, Huang
CLV, Chandrasegaran S, Cai Y, Boeke JD, Bader JS (2017) Design of a synthetic yeast genome.
Science 355:1040–1044
Ricroch A, Clairand P, Harwood W (2017) Use of CRISPR systems in plant genome editing:
toward new opportunities in agriculture. Emerg Top Life Sci 1(2):169–182
Ro D-K, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham
TS, Kirby J, Chang MCY, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of
the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940–943
Roell M-S, Zurbriggen MD (2020) The impact of synthetic biology for future agriculture and
nutrition. Curr Opin Biotech 61:102–109
Rogers C, Oldroyd GED (2014) Synthetic biology approaches to engineering the nitrogen symbiosis in cereals. J Exp Bot 65(8):1939–1946
Rorrer NA, Dorgan JR, Vardon DR, Martinez CR, Yang Y, Beckham GT (2016) Renewable
unsaturated polyesters from muconic acid. ACS Sustain Chem Eng 4:6867–6876
Roy SJ, Negrão S, Tester M (2014) Salt resistant crop plants. Curr Opin Biotechnol 26:115–124
Ruiz-Lopez N, Haslam RP, Napier JA, Sayanova O (2014) Successful high-level accumulation of
fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. Plant J
77:198–208
Ryu MH, Zhang J, Toth T, Khokhani D, Geddes BA, Mus F, Garcia-Costas A, Peters JW, Poole PS,
Ané J-M, Voigt CA (2020) Control of nitrogen fixation in bacteria that associate with cereals.
Nat Microbiol 5(2):314–330
Sánchez-León S, Gil-Humanes J, Ozuna CV, Giménez MJ, Sousa C, Voytas DF, Barro F (2018)
Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9. Plant Biotechnol J 16
(4):902–910
Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De Rosa M, Stefanile R,
Mazzarella G, Tolone C, Russo MI, Esposito P, Ferraraccio F, Cartenì M, Riegler G, de
Magistris L, Fasano A (2011) Divergence of gut permeability and mucosal immune gene
expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC
Med 9:23
Sarrrion-Perdigones A, Vazquez-Vilar M, Palaci J, Castelijns B, Forment J, Ziarsolo P, Blanca J,
Granell A, Orzaez D (2013) GoldenBraid 2.0: a comprehensive DNA assembly framework for
plant synthetic biology. Plant Physiol 162:1618–1631
484
P. Singla