197
Bobadilla Fazzini RA, Skindersoe ME, Bielecki P, Puchałka J, Givskov M, Martins dos
Santos VAP (2013) Protoanemonin: a natural quorum-sensing inhibitor that selectively activates iron starvation response. Environ Microbiol 15:111–120. https://doi.
org/10.1111/j.1462-2920.2012.02792.x
Bodini SF, Manfredini S, Epp M, Valentini S, Santori F (2009) Quorum-sensing inhibition
activity of garlic extract and p -coumaric acid. Lett Appl Microbiol 49:551–555. https://doi.
org/10.1111/j.1472-765X.2009.02704.x
Bortolotti D, Trapella C, Bragonzi A, Marchetti P, Zanirato V, Alogna A, Gentili V, Cervellati C,
Valacchi G, Sicolo M, Turrin G, Fantinati A, Di Luca D, Rizzo R (2019) Conjugation of LasR
quorum-sensing inhibitors with ciprofloxacin decreases the antibiotic tolerance of P. aeruginosa clinical strains. J Chem 2019. https://doi.org/10.1155/2019/8143739
Bouillaut L, Perchat S, Arold S, Zorrilla S, Slamti L, Henry C, Gohar M, Declerck N, Lereclus D
(2008) Molecular basis for group-specific activation of the virulence regulator PlcR by PapR
heptapeptides. Nucleic Acids Res 36:3791–3801. https://doi.org/10.1093/nar/gkn149
Brackman G, Celen S, Hillaert U, Van Calenbergh S, Cos P, Maes L, Nelis HJ, Coenye T (2011a)
Structure-activity relationship of Cinnamaldehyde analogs as inhibitors of AI-2 based quorumsensing and their effect on virulence of Vibrio spp. PLoS One 6:e16084. https://doi.org/10.1371/
journal.pone.0016084
Brackman G, Cos P, Maes L, Nelis HJ, Coenye T (2011b) Quorum-sensing inhibitors increase
the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo. Antimicrob Agents
Chemother 55:2655–2661. https://doi.org/10.1128/AAC.00045-11
Brackman G, Defoirdt T, Miyamoto C, Bossier P, Van Calenbergh S, Nelis H, Coenye T (2008)
Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum-sensing response regulator LuxR. BMC Microbiol
8:149. https://doi.org/10.1186/1471-2180-8-149
Bulman Z, Le P, Hudson AO, Savka MA (2011) A novel property of propolis (bee glue): antipathogenic activity by inhibition of N-acyl-homoserine lactone mediated signaling in bacteria.
J Ethnopharmacol 138:788–797. https://doi.org/10.1016/j.jep.2011.10.029
Bulman ZP, Ly NS, Lenhard JR, Holden PN, Bulitta JB, Tsuji BT (2017) Influence of rhlR and
lasR on Polymyxin pharmacodynamics in Pseudomonas aeruginosa and implications for
quorum-sensing inhibition with azithromycin. Antimicrob Agents Chemother 61. https://doi.
org/10.1128/AAC.00096-16
Buttaro BA, Antiporta MH, Dunny GM (2000) Cell-associated pheromone peptide (cCF10)
production and pheromone inhibition in Enterococcus faecalis. J Bacteriol 182:4926–4933.
https://doi.org/10.1128/JB.182.17.4926-4933.2000
Bzdrenga J, Daudé D, Rémy B, Jacquet P, Plener L, Elias M, Chabrière E (2017a) Biotechnological
applications of quorum quenching enzymes. Chem Biol Interact 267:104–115. https://doi.
org/10.1016/j.cbi.2016.05.028
Bzdrenga J, Daudé D, Rémy B, Jacquet P, Plener L, Elias M, Chabrière E (2017b) Biotechnological
applications of quorum quenching enzymes. Chem Biol Interact 267:104–115. https://doi.
org/10.1016/j.cbi.2016.05.028
Cech NB, Horswill AR (2013) Small-molecule quorum quenchers to prevent Staphylococcus
aureus infection. Future Microbiol 8:1511–1514. https://doi.org/10.2217/fmb.13.134
Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM (2002)
Structural identification of a bacterial quorum-sensing signal containing boron. Nature
415:545–549. https://doi.org/10.1038/415545a
Choi H, Mascuch SJ, Villa FA, Byrum T, Teasdale ME, Smith JE, Preskitt LB, Rowley DC,
Gerwick L, Gerwick WH (2012) Honaucins a−C, potent inhibitors of inflammation and bacterial quorum-sensing: synthetic derivatives and structure-activity relationships. Chem Biol
19:589–598. https://doi.org/10.1016/j.chembiol.2012.03.014
Chong YM, Yin WF, Ho CY, Mustafa MR, Hadi AHA, Awang K, Narrima P, Koh C-L, Appleton
DR, Chan K-G (2011) Malabaricone C from Myristica cinnamomea exhibits anti-quorumsensing activity. J Nat Prod 74:2261–2264. https://doi.org/10.1021/np100872k
8 Intrusion of Bacterial Quorum-Sensing for Antimicrobial Resistance Mitigation…
Bobadilla Fazzini RA, Skindersoe ME, Bielecki P, Puchałka J, Givskov M, Martins dos
Santos VAP (2013) Protoanemonin: a natural quorum-sensing inhibitor that selectively activates iron starvation response. Environ Microbiol 15:111–120. https://doi.
org/10.1111/j.1462-2920.2012.02792.x
Bodini SF, Manfredini S, Epp M, Valentini S, Santori F (2009) Quorum-sensing inhibition
activity of garlic extract and p -coumaric acid. Lett Appl Microbiol 49:551–555. https://doi.
org/10.1111/j.1472-765X.2009.02704.x
Bortolotti D, Trapella C, Bragonzi A, Marchetti P, Zanirato V, Alogna A, Gentili V, Cervellati C,
Valacchi G, Sicolo M, Turrin G, Fantinati A, Di Luca D, Rizzo R (2019) Conjugation of LasR
quorum-sensing inhibitors with ciprofloxacin decreases the antibiotic tolerance of P. aeruginosa clinical strains. J Chem 2019. https://doi.org/10.1155/2019/8143739
Bouillaut L, Perchat S, Arold S, Zorrilla S, Slamti L, Henry C, Gohar M, Declerck N, Lereclus D
(2008) Molecular basis for group-specific activation of the virulence regulator PlcR by PapR
heptapeptides. Nucleic Acids Res 36:3791–3801. https://doi.org/10.1093/nar/gkn149
Brackman G, Celen S, Hillaert U, Van Calenbergh S, Cos P, Maes L, Nelis HJ, Coenye T (2011a)
Structure-activity relationship of Cinnamaldehyde analogs as inhibitors of AI-2 based quorumsensing and their effect on virulence of Vibrio spp. PLoS One 6:e16084. https://doi.org/10.1371/
journal.pone.0016084
Brackman G, Cos P, Maes L, Nelis HJ, Coenye T (2011b) Quorum-sensing inhibitors increase
the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo. Antimicrob Agents
Chemother 55:2655–2661. https://doi.org/10.1128/AAC.00045-11
Brackman G, Defoirdt T, Miyamoto C, Bossier P, Van Calenbergh S, Nelis H, Coenye T (2008)
Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum-sensing response regulator LuxR. BMC Microbiol
8:149. https://doi.org/10.1186/1471-2180-8-149
Bulman Z, Le P, Hudson AO, Savka MA (2011) A novel property of propolis (bee glue): antipathogenic activity by inhibition of N-acyl-homoserine lactone mediated signaling in bacteria.
J Ethnopharmacol 138:788–797. https://doi.org/10.1016/j.jep.2011.10.029
Bulman ZP, Ly NS, Lenhard JR, Holden PN, Bulitta JB, Tsuji BT (2017) Influence of rhlR and
lasR on Polymyxin pharmacodynamics in Pseudomonas aeruginosa and implications for
quorum-sensing inhibition with azithromycin. Antimicrob Agents Chemother 61. https://doi.
org/10.1128/AAC.00096-16
Buttaro BA, Antiporta MH, Dunny GM (2000) Cell-associated pheromone peptide (cCF10)
production and pheromone inhibition in Enterococcus faecalis. J Bacteriol 182:4926–4933.
https://doi.org/10.1128/JB.182.17.4926-4933.2000
Bzdrenga J, Daudé D, Rémy B, Jacquet P, Plener L, Elias M, Chabrière E (2017a) Biotechnological
applications of quorum quenching enzymes. Chem Biol Interact 267:104–115. https://doi.
org/10.1016/j.cbi.2016.05.028
Bzdrenga J, Daudé D, Rémy B, Jacquet P, Plener L, Elias M, Chabrière E (2017b) Biotechnological
applications of quorum quenching enzymes. Chem Biol Interact 267:104–115. https://doi.
org/10.1016/j.cbi.2016.05.028
Cech NB, Horswill AR (2013) Small-molecule quorum quenchers to prevent Staphylococcus
aureus infection. Future Microbiol 8:1511–1514. https://doi.org/10.2217/fmb.13.134
Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM (2002)
Structural identification of a bacterial quorum-sensing signal containing boron. Nature
415:545–549. https://doi.org/10.1038/415545a
Choi H, Mascuch SJ, Villa FA, Byrum T, Teasdale ME, Smith JE, Preskitt LB, Rowley DC,
Gerwick L, Gerwick WH (2012) Honaucins a−C, potent inhibitors of inflammation and bacterial quorum-sensing: synthetic derivatives and structure-activity relationships. Chem Biol
19:589–598. https://doi.org/10.1016/j.chembiol.2012.03.014
Chong YM, Yin WF, Ho CY, Mustafa MR, Hadi AHA, Awang K, Narrima P, Koh C-L, Appleton
DR, Chan K-G (2011) Malabaricone C from Myristica cinnamomea exhibits anti-quorumsensing activity. J Nat Prod 74:2261–2264. https://doi.org/10.1021/np100872k
8 Intrusion of Bacterial Quorum-Sensing for Antimicrobial Resistance Mitigation…