196
8.9 Conclusion
The study of bacterial quorum sensing systems is intended to exploit the molecular
pathways and mechanisms involved in cell-cell communication. In bacteria, quorum sensing is a universal communication mechanism to regulate the traits through
exchanging the extra-cellular signaling molecules called auto inducers according to
surrounding conditions. The changes in the behavior depend on the type and concentration of signaling molecules. New research shows that these signaling molecules are extremely species and genus specific. Based on the information garnered
from quorum sensing studies, manipulating the signaling molecules are now viewed
as promising strategies in various practical applications. The continuing research
directed at finding the natural quorum sensing inhibitors and their synthetic analogs
for the clinical uses has developed the advanced therapies for the treatment of resistant bacteria. Presumably, these therapies will not be as prone to resistance as are
the traditional antibiotics. The use of quorum sensing inhibitors in the clinical
approaches could have better functions than next-generation antibiotics and would
play an important role in the antimicrobial resistance mitigation.
References
Abed RMM, Dobretsov S, Al-Fori M, Gunasekera SP, Sudesh K, Paul VJ (2013) Quorumsensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat. J Ind Microbiol Biotechnol 40:759–772. https://doi.org/10.1007/
s10295-013-1276-4
Adonizio A, Dawlaty J, Ausubel F, Clardy J, Mathee K (2008) Ellagitannins from Conocarpus
erectus exhibit anti-quorum-sensing activity against Pseudomonas aeruginosa. Planta Med 74.
https://doi.org/10.1055/s-0028-1084373
Aleksić I, Šegan S, Andrić F, Zlatović M, Moric I, Opsenica DM, Senerovic L (2017) Long-chain
4-Aminoquinolines as quorum-sensing inhibitors in Serratia marcescens and Pseudomonas
aeruginosa. ACS Chem Biol 12:1425–1434. https://doi.org/10.1021/acschembio.6b01149
Amaya S, Pereira JA, Borkosky SA, Valdez JC, Bardón A, Arena ME (2012) Inhibition of quorumsensing in Pseudomonas aeruginosa by sesquiterpene lactones. Phytomedicine 19:1173–1177.
https://doi.org/10.1016/j.phymed.2012.07.003
Kumari A, Pasini P, Deo SK, Flomenhoft D, Shashidhar H, Daunert S (2006) Biosensing systems
for the detection of bacterial quorum signaling molecules. https://doi.org/10.1021/AC061421N
Bahari S, Zeighami H, Mirshahabi H, Roudashti S, Haghi F (2017) Inhibition of Pseudomonas
aeruginosa quorum-sensing by subinhibitory concentrations of curcumin with gentamicin and
azithromycin. Journal of global antimicrobial resistance 10:21–28. https://doi.org/10.1016/j.
jgar.2017.03.006
Bhatt VS (2018) Quorum-sensing mechanisms in gram positive bacteria. In: Implication of
quorum-sensing system in biofilm formation and virulence. Springer Singapore, Singapore,
pp 297–311
Bjarnsholt T, Jensen PØ, Burmølle M, Hentzer M, Haagensen JAJ, Hougen HP, Calum H, Madsen
KG, Moser C, Molin S, Høiby N, Givskov M (2005) Pseudomonas aeruginosa tolerance to
tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology 151:373–383. https://doi.org/10.1099/mic.0.27463-0
S. Kumar et al.
8.9 Conclusion
The study of bacterial quorum sensing systems is intended to exploit the molecular
pathways and mechanisms involved in cell-cell communication. In bacteria, quorum sensing is a universal communication mechanism to regulate the traits through
exchanging the extra-cellular signaling molecules called auto inducers according to
surrounding conditions. The changes in the behavior depend on the type and concentration of signaling molecules. New research shows that these signaling molecules are extremely species and genus specific. Based on the information garnered
from quorum sensing studies, manipulating the signaling molecules are now viewed
as promising strategies in various practical applications. The continuing research
directed at finding the natural quorum sensing inhibitors and their synthetic analogs
for the clinical uses has developed the advanced therapies for the treatment of resistant bacteria. Presumably, these therapies will not be as prone to resistance as are
the traditional antibiotics. The use of quorum sensing inhibitors in the clinical
approaches could have better functions than next-generation antibiotics and would
play an important role in the antimicrobial resistance mitigation.
References
Abed RMM, Dobretsov S, Al-Fori M, Gunasekera SP, Sudesh K, Paul VJ (2013) Quorumsensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat. J Ind Microbiol Biotechnol 40:759–772. https://doi.org/10.1007/
s10295-013-1276-4
Adonizio A, Dawlaty J, Ausubel F, Clardy J, Mathee K (2008) Ellagitannins from Conocarpus
erectus exhibit anti-quorum-sensing activity against Pseudomonas aeruginosa. Planta Med 74.
https://doi.org/10.1055/s-0028-1084373
Aleksić I, Šegan S, Andrić F, Zlatović M, Moric I, Opsenica DM, Senerovic L (2017) Long-chain
4-Aminoquinolines as quorum-sensing inhibitors in Serratia marcescens and Pseudomonas
aeruginosa. ACS Chem Biol 12:1425–1434. https://doi.org/10.1021/acschembio.6b01149
Amaya S, Pereira JA, Borkosky SA, Valdez JC, Bardón A, Arena ME (2012) Inhibition of quorumsensing in Pseudomonas aeruginosa by sesquiterpene lactones. Phytomedicine 19:1173–1177.
https://doi.org/10.1016/j.phymed.2012.07.003
Kumari A, Pasini P, Deo SK, Flomenhoft D, Shashidhar H, Daunert S (2006) Biosensing systems
for the detection of bacterial quorum signaling molecules. https://doi.org/10.1021/AC061421N
Bahari S, Zeighami H, Mirshahabi H, Roudashti S, Haghi F (2017) Inhibition of Pseudomonas
aeruginosa quorum-sensing by subinhibitory concentrations of curcumin with gentamicin and
azithromycin. Journal of global antimicrobial resistance 10:21–28. https://doi.org/10.1016/j.
jgar.2017.03.006
Bhatt VS (2018) Quorum-sensing mechanisms in gram positive bacteria. In: Implication of
quorum-sensing system in biofilm formation and virulence. Springer Singapore, Singapore,
pp 297–311
Bjarnsholt T, Jensen PØ, Burmølle M, Hentzer M, Haagensen JAJ, Hougen HP, Calum H, Madsen
KG, Moser C, Molin S, Høiby N, Givskov M (2005) Pseudomonas aeruginosa tolerance to
tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology 151:373–383. https://doi.org/10.1099/mic.0.27463-0
S. Kumar et al.