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and precedes bloodstream invasion in humans. J Clin Invest 120(12):4332–4341. https://doi.
org/10.1172/JCI43918
Uddin R, Zahra NU, Azam SS (2019) Identification of glucosyl-3-phosphoglycerate phosphatase
as a novel drug target against resistant strain of Mycobacterium tuberculosis (XDR1219) by
using comparative metabolic pathway approach. Comput Biol Chem 79:91–102. https://doi.
org/10.1016/j.compbiolchem.2019.01.011
Urban M, Cuzick A, Rutherford K, Irvine A, Pedro H, Pant R et al (2017) PHI-base: a new interface and further additions for the multi-species pathogen-host interactions database. Nucleic
Acids Res 45(D1):D604–D610. https://doi.org/10.1093/nar/gkw1089
Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP et al (2015) Global
trends in antimicrobial use in food animals. Proc Natl Acad Sci U S A 112(18):5649–5654.
https://doi.org/10.1073/pnas.1503141112
Vernikos G, Medini D, Riley DR, Tettelin H (2015) Ten years of pan-genome analyses. Curr Opin
Microbiol 23:148–154. https://doi.org/10.1016/j.mib.2014.11.016
Vydyam P, Dutta D, Sutram N, Bhattacharyya S, Bhattacharyya MK (2019) A small-molecule
inhibitor of the DNA recombinase Rad51 from Plasmodium falciparum synergizes with the
antimalarial drugs artemisinin and chloroquine. J Biol Chem 294(20):8171–8183. https://doi.
org/10.1074/jbc.RA118.005009
Wadood A, Jamal A, Riaz M, Khan A, Uddin R, Jelani M et al (2018) Subtractive genome analysis
for in silico identification and characterization of novel drug targets in Streptococcus pneumonia strain JJA. Microb Pathog 115:194–198. https://doi.org/10.1016/j.micpath.2017.12.063
Waman VP, Vedithi SC, Thomas SE, Bannerman BP, Munir A, Skwark MJ et al (2019)
Mycobacterial genomics and structural bioinformatics: opportunities and challenges in
drug discovery. Emerg Microbes Infect 8(1):109–118. https://doi.org/10.1080/2222175
1.2018.1561158
Warrenfeltz S, Basenko EY, Crouch K, Harb OS, Kissinger JC, Roos DS et al (2018) EuPathDB:
the eukaryotic pathogen genomics database resource. Methods Mol Biol 1757:69–113. https://
doi.org/10.1007/978-1-4939-7737-6_5
Wattam AR, Davis JJ, Assaf R, Boisvert S, Brettin T, Bun C et al (2017) Improvements to PATRIC,
the all-bacterial bioinformatics database and analysis resource center. Nucleic Acids Res
45(D1):D535–D542. https://doi.org/10.1093/nar/gkw1017
Wensing AM, Calvez V, Günthard HF, Johnson VA, Paredes R, Pillay D et al (2017) 2017 update
of the drug resistance mutations in HIV-1. Topics Antiviral Med 24(4):132–133
WHO (2015) Global action plan on antimicrobial resistance. WHO, Geneva. https://www.who.int/
antimicrobial-resistance/publications/global-action-plan/en/
WHO (2018a) 2018 assessment report of the global vaccine action plan. Strategic Advisory
Group of Experts on Immunization. World Health Organization, Geneva. https://
www.who.int/immunization/global_vaccine_action_plan/SAGE_GVAP_Assessment_
Report_2018_EN.pdf?ua=1
WHO (2018b) World malaria report 2018. WHO, Geneva. https://www.who.int/malaria/
publications/world-malaria-report-2018/report/en/
Xiang Z, Tian Y, He Y (2007) PHIDIAS: a pathogen-host interaction data integration and analysis
system. Genome Biol 8(7):R150. https://doi.org/10.1186/gb-2007-8-7-r150
Zaas AK, Burke T, Chen M, McClain M, Nicholson B, Veldman T et al (2013) A host-based
RT-PCR gene expression signature to identify acute respiratory viral infection. Science
Translational Medicine 5(203):203ra126. https://doi.org/10.1126/scitranslmed.3006280
Zhou H, Jin J, Zhang H, Yi B, Wozniak M, Wong L (2012) IntPath--an integrated pathway gene
relationship database for model organisms and important pathogens. BMC Syst Biol 6(Suppl
2):S2. https://doi.org/10.1186/1752-0509-6-S2-S2
Zhou H, Jin J, Wong L (2013) Progress in computational studies of host-pathogen interactions. J
Bioinforma Comput Biol 11(2):1230001. https://doi.org/10.1142/S0219720012300018
M. Santana et al.
and precedes bloodstream invasion in humans. J Clin Invest 120(12):4332–4341. https://doi.
org/10.1172/JCI43918
Uddin R, Zahra NU, Azam SS (2019) Identification of glucosyl-3-phosphoglycerate phosphatase
as a novel drug target against resistant strain of Mycobacterium tuberculosis (XDR1219) by
using comparative metabolic pathway approach. Comput Biol Chem 79:91–102. https://doi.
org/10.1016/j.compbiolchem.2019.01.011
Urban M, Cuzick A, Rutherford K, Irvine A, Pedro H, Pant R et al (2017) PHI-base: a new interface and further additions for the multi-species pathogen-host interactions database. Nucleic
Acids Res 45(D1):D604–D610. https://doi.org/10.1093/nar/gkw1089
Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP et al (2015) Global
trends in antimicrobial use in food animals. Proc Natl Acad Sci U S A 112(18):5649–5654.
https://doi.org/10.1073/pnas.1503141112
Vernikos G, Medini D, Riley DR, Tettelin H (2015) Ten years of pan-genome analyses. Curr Opin
Microbiol 23:148–154. https://doi.org/10.1016/j.mib.2014.11.016
Vydyam P, Dutta D, Sutram N, Bhattacharyya S, Bhattacharyya MK (2019) A small-molecule
inhibitor of the DNA recombinase Rad51 from Plasmodium falciparum synergizes with the
antimalarial drugs artemisinin and chloroquine. J Biol Chem 294(20):8171–8183. https://doi.
org/10.1074/jbc.RA118.005009
Wadood A, Jamal A, Riaz M, Khan A, Uddin R, Jelani M et al (2018) Subtractive genome analysis
for in silico identification and characterization of novel drug targets in Streptococcus pneumonia strain JJA. Microb Pathog 115:194–198. https://doi.org/10.1016/j.micpath.2017.12.063
Waman VP, Vedithi SC, Thomas SE, Bannerman BP, Munir A, Skwark MJ et al (2019)
Mycobacterial genomics and structural bioinformatics: opportunities and challenges in
drug discovery. Emerg Microbes Infect 8(1):109–118. https://doi.org/10.1080/2222175
1.2018.1561158
Warrenfeltz S, Basenko EY, Crouch K, Harb OS, Kissinger JC, Roos DS et al (2018) EuPathDB:
the eukaryotic pathogen genomics database resource. Methods Mol Biol 1757:69–113. https://
doi.org/10.1007/978-1-4939-7737-6_5
Wattam AR, Davis JJ, Assaf R, Boisvert S, Brettin T, Bun C et al (2017) Improvements to PATRIC,
the all-bacterial bioinformatics database and analysis resource center. Nucleic Acids Res
45(D1):D535–D542. https://doi.org/10.1093/nar/gkw1017
Wensing AM, Calvez V, Günthard HF, Johnson VA, Paredes R, Pillay D et al (2017) 2017 update
of the drug resistance mutations in HIV-1. Topics Antiviral Med 24(4):132–133
WHO (2015) Global action plan on antimicrobial resistance. WHO, Geneva. https://www.who.int/
antimicrobial-resistance/publications/global-action-plan/en/
WHO (2018a) 2018 assessment report of the global vaccine action plan. Strategic Advisory
Group of Experts on Immunization. World Health Organization, Geneva. https://
www.who.int/immunization/global_vaccine_action_plan/SAGE_GVAP_Assessment_
Report_2018_EN.pdf?ua=1
WHO (2018b) World malaria report 2018. WHO, Geneva. https://www.who.int/malaria/
publications/world-malaria-report-2018/report/en/
Xiang Z, Tian Y, He Y (2007) PHIDIAS: a pathogen-host interaction data integration and analysis
system. Genome Biol 8(7):R150. https://doi.org/10.1186/gb-2007-8-7-r150
Zaas AK, Burke T, Chen M, McClain M, Nicholson B, Veldman T et al (2013) A host-based
RT-PCR gene expression signature to identify acute respiratory viral infection. Science
Translational Medicine 5(203):203ra126. https://doi.org/10.1126/scitranslmed.3006280
Zhou H, Jin J, Zhang H, Yi B, Wozniak M, Wong L (2012) IntPath--an integrated pathway gene
relationship database for model organisms and important pathogens. BMC Syst Biol 6(Suppl
2):S2. https://doi.org/10.1186/1752-0509-6-S2-S2
Zhou H, Jin J, Wong L (2013) Progress in computational studies of host-pathogen interactions. J
Bioinforma Comput Biol 11(2):1230001. https://doi.org/10.1142/S0219720012300018
M. Santana et al.