phosphorylates JAM-A at Ser285 to promote
cell contact maturation and tight junction formation. J Cell Biol 196:623–639
97. Albertson R (2004) Scribble protein domain
mapping reveals a multistep localization
mechanism and domains necessary for establishing cortical polarity. J Cell Sci
117:6061–6070
98. Zeitler J, Hsu CP, Dionne H, Bilder D (2004)
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor
Scribble. J Cell Biol 167:1137–1146
99. Audebert S, Navarro C, Nourry C, ChasserotGolaz S, Le ´cine P, Bellaiche Y, Dupont J-L,
Premont RT, Sempe ´re ´ C, Strub J-M, Van
Dorsselaer A, Vitale N, Borg J-P (2004)
Mammalian Scribble forms a tight complex
with the betaPIX exchange factor. Curr Biol
14:987–995
100. Kallay LM, McNickle A, Brennwald PJ, Hubbard AL, Braiterman LT (2006) Scribble
associates with two polarity proteins, lgl2
and vangl2, via distinct molecular domains. J
Cell Biochem 99:647–664
101. Wang X, Dong B, Zhang K, Ji Z, Cheng C,
Zhao H, Sheng Y, Li X, Fan L, Xue W, Gao
W-Q, Zhu HH (2018) E-cadherin bridges
cell polarity and spindle orientation to ensure
prostate epithelial integrity and prevent carcinogenesis in vivo. PLoS Genet 14:e1007609
102. Osmani N, Vitale N, Borg J-P, Etienne-Manneville S (2006) Scrib controls Cdc42 localization and activity to promote cell
polarization during astrocyte migration.
Curr Biol 16:2395–2405
103. Lohia M, Qin Y, Macara IG (2012) The
Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks
retrieval of E-cadherin to the golgi. PLoS
One 7:e51130
104. le Duc Q, Shi Q, Blonk I, Sonnenberg A,
Wang N, Leckband D, de Rooij J (2010)
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites
within adherens junctions in a myosin
II-dependent
manner.
J
Cell
Biol
189:1107–1115
105. Borghi N, Sorokina M, Shcherbakova OG,
Weis WI, Pruitt BL, Nelson WJ, Dunn AR
(2012) E-cadherin is under constitutive
actomyosin-generated tension that is
increased at cell–cell contacts upon externally
applied stretch. Proc Natl Acad Sci U S A
109:12568–12573
106. Bazellie `res E, Conte V, Elosegui-Artola A,
Serra-Picamal X, Bintanel-Morcillo M, RocaCusachs P, Mun ˜oz JJ, Sales-Pardo M,
Guimera ` R, Trepat X (2015) Control of cellcell forces and collective cell dynamics by the
intercellular adhesome. Nat Cell Biol
17:409–420
107. Wu SK, Lagendijk AK, Hogan BM, Gomez
GA, Yap AS (2015) Active contractility at
E-cadherin junctions and its implications for
cell extrusion in cancer. Cell Cycle
14:315–322
108. Engl W, Arasi B, Yap LL, Thiery JP, Viasnoff
V (2014) Actin dynamics modulate mechanosensitive immobilization of E-cadherin at
adherens
junctions.
Nat
Cell
Biol
16:584–591
109. Wu SK, Gomez GA, Michael M, Verma S,
Cox HL, Lefevre JG, Parton RG, Hamilton
NA, Neufeld Z, Yap AS (2014) Cortical
F-actin stabilization generates apical-lateral
patterns of junctional contractility that integrate cells into epithelia. Nat Cell Biol
16:167–178
110. Lugo-Martı ´nez V-H, Petit CS, Fouquet S, Le
Beyec J, Chambaz J, Pinc ¸on-Raymond M,
Cardot P, Thenet S (2009) Epidermal growth
factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherinmediated junctions. Am J Physiol Gastrointest Liver Physiol 296:G235–G244
111. Choi J, Troyanovsky RB, Indra I, Mitchell BJ,
Troyanovsky SM (2019) Scribble, Erbin, and
Lano redundantly regulate epithelial polarity
and apical adhesion complex. J Cell Biol
218:2277–2293
112. Yoshihara K, Ikenouchi J, Izumi Y, Akashi M,
Tsukita S, Furuse M (2011) Phosphorylation
state regulates the localization of Scribble at
adherens junctions and its association with Ecadherin-catenin complexes. Exp Cell Res
317:413–422
113. Meng W, Mushika Y, Ichii T, Takeichi M
(2008) Anchorage of microtubule minus
ends to adherens junctions regulates epithelial
cell-cell contacts. Cell 135:948–959
114. Priya R, Yap AS, Gomez GA (2013)
E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens. Differentiation 86:133–140
115. Truong Quang B-A, Mani M, Markova O,
Lecuit T, Lenne P-F (2013) Principles of
E-cadherin supramolecular organization
in vivo. Curr Biol 23:2197–2207
116. Hart KC, Tan J, Siemers KA, Sim JY, Pruitt
BL, Nelson WJ, Gloerich M (2017)
E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell
shape. Proc Natl Acad Sci U S A 114(29):
274
Elsa Bazellie ` res and Andre ´ Le Bivic
cell contact maturation and tight junction formation. J Cell Biol 196:623–639
97. Albertson R (2004) Scribble protein domain
mapping reveals a multistep localization
mechanism and domains necessary for establishing cortical polarity. J Cell Sci
117:6061–6070
98. Zeitler J, Hsu CP, Dionne H, Bilder D (2004)
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor
Scribble. J Cell Biol 167:1137–1146
99. Audebert S, Navarro C, Nourry C, ChasserotGolaz S, Le ´cine P, Bellaiche Y, Dupont J-L,
Premont RT, Sempe ´re ´ C, Strub J-M, Van
Dorsselaer A, Vitale N, Borg J-P (2004)
Mammalian Scribble forms a tight complex
with the betaPIX exchange factor. Curr Biol
14:987–995
100. Kallay LM, McNickle A, Brennwald PJ, Hubbard AL, Braiterman LT (2006) Scribble
associates with two polarity proteins, lgl2
and vangl2, via distinct molecular domains. J
Cell Biochem 99:647–664
101. Wang X, Dong B, Zhang K, Ji Z, Cheng C,
Zhao H, Sheng Y, Li X, Fan L, Xue W, Gao
W-Q, Zhu HH (2018) E-cadherin bridges
cell polarity and spindle orientation to ensure
prostate epithelial integrity and prevent carcinogenesis in vivo. PLoS Genet 14:e1007609
102. Osmani N, Vitale N, Borg J-P, Etienne-Manneville S (2006) Scrib controls Cdc42 localization and activity to promote cell
polarization during astrocyte migration.
Curr Biol 16:2395–2405
103. Lohia M, Qin Y, Macara IG (2012) The
Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks
retrieval of E-cadherin to the golgi. PLoS
One 7:e51130
104. le Duc Q, Shi Q, Blonk I, Sonnenberg A,
Wang N, Leckband D, de Rooij J (2010)
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites
within adherens junctions in a myosin
II-dependent
manner.
J
Cell
Biol
189:1107–1115
105. Borghi N, Sorokina M, Shcherbakova OG,
Weis WI, Pruitt BL, Nelson WJ, Dunn AR
(2012) E-cadherin is under constitutive
actomyosin-generated tension that is
increased at cell–cell contacts upon externally
applied stretch. Proc Natl Acad Sci U S A
109:12568–12573
106. Bazellie `res E, Conte V, Elosegui-Artola A,
Serra-Picamal X, Bintanel-Morcillo M, RocaCusachs P, Mun ˜oz JJ, Sales-Pardo M,
Guimera ` R, Trepat X (2015) Control of cellcell forces and collective cell dynamics by the
intercellular adhesome. Nat Cell Biol
17:409–420
107. Wu SK, Lagendijk AK, Hogan BM, Gomez
GA, Yap AS (2015) Active contractility at
E-cadherin junctions and its implications for
cell extrusion in cancer. Cell Cycle
14:315–322
108. Engl W, Arasi B, Yap LL, Thiery JP, Viasnoff
V (2014) Actin dynamics modulate mechanosensitive immobilization of E-cadherin at
adherens
junctions.
Nat
Cell
Biol
16:584–591
109. Wu SK, Gomez GA, Michael M, Verma S,
Cox HL, Lefevre JG, Parton RG, Hamilton
NA, Neufeld Z, Yap AS (2014) Cortical
F-actin stabilization generates apical-lateral
patterns of junctional contractility that integrate cells into epithelia. Nat Cell Biol
16:167–178
110. Lugo-Martı ´nez V-H, Petit CS, Fouquet S, Le
Beyec J, Chambaz J, Pinc ¸on-Raymond M,
Cardot P, Thenet S (2009) Epidermal growth
factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherinmediated junctions. Am J Physiol Gastrointest Liver Physiol 296:G235–G244
111. Choi J, Troyanovsky RB, Indra I, Mitchell BJ,
Troyanovsky SM (2019) Scribble, Erbin, and
Lano redundantly regulate epithelial polarity
and apical adhesion complex. J Cell Biol
218:2277–2293
112. Yoshihara K, Ikenouchi J, Izumi Y, Akashi M,
Tsukita S, Furuse M (2011) Phosphorylation
state regulates the localization of Scribble at
adherens junctions and its association with Ecadherin-catenin complexes. Exp Cell Res
317:413–422
113. Meng W, Mushika Y, Ichii T, Takeichi M
(2008) Anchorage of microtubule minus
ends to adherens junctions regulates epithelial
cell-cell contacts. Cell 135:948–959
114. Priya R, Yap AS, Gomez GA (2013)
E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens. Differentiation 86:133–140
115. Truong Quang B-A, Mani M, Markova O,
Lecuit T, Lenne P-F (2013) Principles of
E-cadherin supramolecular organization
in vivo. Curr Biol 23:2197–2207
116. Hart KC, Tan J, Siemers KA, Sim JY, Pruitt
BL, Nelson WJ, Gloerich M (2017)
E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell
shape. Proc Natl Acad Sci U S A 114(29):
274
Elsa Bazellie ` res and Andre ´ Le Bivic