Hoos S, England P, Delepierre M, Schnell MJ,
Buc H, Lafon M (2010) Attenuation of rabies
virulence: takeover by the cytoplasmic domain
of its envelope protein. Sci Signal 3:ra5
56. Terrien E, Chaffotte A, Lafage M, Khan Z,
Prehaud C, Cordier F, Simenel C,
Delepierre M, Buc H, Lafon M, Wolff N
(2012) Interference with the PTEN-MAST2
interaction by a viral protein leads to cellular
relocalization of PTEN. Sci Signal 5:ra58
57. Seo W, Prehaud C, Khan Z, Sabeta C, Lafon M
(2017) Investigation of rabies virus glycoprotein carboxyl terminus as an in vitro predictive
tool of neurovirulence. A 3R approach.
Microbes Infect 19:476–484
58. Seo W, Servat A, Cliquet F, Akinbowale J,
Prehaud C, Lafon M, Sabeta C (2017) Comparison of G protein sequences of
South African street rabies viruses showing distinct progression of the disease in a mouse
model of experimental rabies. Microbes Infect
19:485–491
59. Barreda D, Sanchez-Galindo M, Lopez-FloresJ, Nava-Castro KE, Bobadilla K, SalgadoAguayo A, Santos-Mendoza T (2018) PDZ
proteins are expressed and regulated in
antigen-presenting cells and are targets of influenza A virus. J Leukoc Biol 103:731–738
60. Platanias LC (2005) Mechanisms of type-Iand type-II-interferon-mediated signalling.
Nat Rev Immunol 5:375–386
61. Werme K, Wigerius M, Johansson M (2008)
Tick-borne encephalitis virus NS5 associates
with membrane protein scribble and impairs
interferon-stimulated JAK-STAT signalling.
Cell Microbiol 10:696–712
62. King NJ, Getts DR, Getts MT, Rana S,
Shrestha B, Kesson AM (2007) Immunopathology of flavivirus infections. Immunol Cell
Biol 85:33–42
63. Fernandez-Garcia MD, Mazzon M, Jacobs M,
Amara A (2009) Pathogenesis of flavivirus
infections: using and abusing the host cell.
Cell Host Microbe 5:318–328
64. Yilla M, Harcourt BH, Hickman CJ,
McGrew M, Tamin A, Goldsmith CS, Bellini
WJ, Anderson LJ (2005) SARS-coronavirus
replication in human peripheral monocytes/
macrophages. Virus Res 107:93–101
65. Zhou J, Chu H, Li C, Wong BH, Cheng ZS,
Poon VK, Sun T, Lau CC, Wong KK, Chan JY,
Chan JF, To KK, Chan KH, Zheng BJ, Yuen
KY (2014) Active replication of Middle East
respiratory syndrome coronavirus and aberrant
induction of inflammatory cytokines and chemokines in human macrophages: implications
for pathogenesis. J Infect Dis 209:1331–1342
66. Jimenez-Guardeno JM, Regla-Nava JA, NietoTorres JL, DeDiego ML, Castano-RodriguezC, Fernandez-Delgado R, Perlman S, Enjuanes
L (2015) Identification of the mechanisms
causing reversion to virulence in an attenuated
SARS-CoV for the design of a genetically stable
vaccine. PLoS Pathog 11:e1005215
67. Castan ˜o-Rodriguez C, Honrubia JM, Gutie ´rrez-A ´ lvarez J, DeDiego ML, Nieto-Torres JL,
Jimenez-Guarden ˜o JM, Regla-Nava JA,
Fernandez-Delgado R, Verdia-Ba ´guena C,
Queralt-Martı ´n M, Kochan G, Perlman S,
Aguilella VM, Sola I, Enjuanes L (2018) Role
of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and
pathogenesis. mBio 9:e2325–e2317
68. Stodola JK, Dubois G, Le Coupanec A,
Desforges M, Talbot PJ (2018) The OC43
human coronavirus envelope protein is critical
for infectious virus production and propagation in neuronal cells and is a determinant of
neurovirulence and CNS pathology. Virology
515:134–149
69. Florek D, Ehmann R, Kristen-Burmann C,
Lemmermeyer T, Lochnit G, Ziebuhr J, Thiel
HJ, Tekes G (2017) Identification and characterization of a Golgi retention signal in feline
coronavirus accessory protein 7b. J Gen Virol
98:2017–2029
70. Gorbalenya AE, Baker SC, Baric RS, de Groot
RJ, Drosten C, Gulyaeva AA, Haagmans BL,
Lauber C, Leontovich AM, Neuman BW,
Penzar D, Perlman S, LLM P, Samborskiy
DV, Sidorov IA, Sola I, Ziebuhr J, Coronaviridae Study Group of the International Committee on Taxonomy of V (2020) The species
severe acute respiratory syndrome-related
coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5:536–544
71. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H,
Wang W, Song H, Huang B, Zhu N, Bi Y,
Ma X, Zhan F, Wang L, Hu T, Zhou H,
Hu Z, Zhou W, Zhao L, Chen J, Meng Y,
Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ,
Wang D, Xu W, Holmes EC, Gao GF, Wu G,
Chen W, Shi W, Tan W (2020) Genomic characterisation and epidemiology of 2019 novel
coronavirus: implications for virus origins and
receptor binding. Lancet 395:565–574
72. Lau SK, Woo PC, Li KS, Tsang AK, Fan RY,
Luk HK, Cai JP, Chan KH, Zheng BJ,
Wang M, Yuen KY (2015) Discovery of a
novel coronavirus, China Rattus coronavirus
HKU24, from Norway rats supports the
murine origin of Betacoronavirus 1 and has
implications for the ancestor of Betacoronavirus lineage A. J Virol 89:3076–3092
PBM-PDZ Interactions and Viral Pathogenesis
235
Buc H, Lafon M (2010) Attenuation of rabies
virulence: takeover by the cytoplasmic domain
of its envelope protein. Sci Signal 3:ra5
56. Terrien E, Chaffotte A, Lafage M, Khan Z,
Prehaud C, Cordier F, Simenel C,
Delepierre M, Buc H, Lafon M, Wolff N
(2012) Interference with the PTEN-MAST2
interaction by a viral protein leads to cellular
relocalization of PTEN. Sci Signal 5:ra58
57. Seo W, Prehaud C, Khan Z, Sabeta C, Lafon M
(2017) Investigation of rabies virus glycoprotein carboxyl terminus as an in vitro predictive
tool of neurovirulence. A 3R approach.
Microbes Infect 19:476–484
58. Seo W, Servat A, Cliquet F, Akinbowale J,
Prehaud C, Lafon M, Sabeta C (2017) Comparison of G protein sequences of
South African street rabies viruses showing distinct progression of the disease in a mouse
model of experimental rabies. Microbes Infect
19:485–491
59. Barreda D, Sanchez-Galindo M, Lopez-FloresJ, Nava-Castro KE, Bobadilla K, SalgadoAguayo A, Santos-Mendoza T (2018) PDZ
proteins are expressed and regulated in
antigen-presenting cells and are targets of influenza A virus. J Leukoc Biol 103:731–738
60. Platanias LC (2005) Mechanisms of type-Iand type-II-interferon-mediated signalling.
Nat Rev Immunol 5:375–386
61. Werme K, Wigerius M, Johansson M (2008)
Tick-borne encephalitis virus NS5 associates
with membrane protein scribble and impairs
interferon-stimulated JAK-STAT signalling.
Cell Microbiol 10:696–712
62. King NJ, Getts DR, Getts MT, Rana S,
Shrestha B, Kesson AM (2007) Immunopathology of flavivirus infections. Immunol Cell
Biol 85:33–42
63. Fernandez-Garcia MD, Mazzon M, Jacobs M,
Amara A (2009) Pathogenesis of flavivirus
infections: using and abusing the host cell.
Cell Host Microbe 5:318–328
64. Yilla M, Harcourt BH, Hickman CJ,
McGrew M, Tamin A, Goldsmith CS, Bellini
WJ, Anderson LJ (2005) SARS-coronavirus
replication in human peripheral monocytes/
macrophages. Virus Res 107:93–101
65. Zhou J, Chu H, Li C, Wong BH, Cheng ZS,
Poon VK, Sun T, Lau CC, Wong KK, Chan JY,
Chan JF, To KK, Chan KH, Zheng BJ, Yuen
KY (2014) Active replication of Middle East
respiratory syndrome coronavirus and aberrant
induction of inflammatory cytokines and chemokines in human macrophages: implications
for pathogenesis. J Infect Dis 209:1331–1342
66. Jimenez-Guardeno JM, Regla-Nava JA, NietoTorres JL, DeDiego ML, Castano-RodriguezC, Fernandez-Delgado R, Perlman S, Enjuanes
L (2015) Identification of the mechanisms
causing reversion to virulence in an attenuated
SARS-CoV for the design of a genetically stable
vaccine. PLoS Pathog 11:e1005215
67. Castan ˜o-Rodriguez C, Honrubia JM, Gutie ´rrez-A ´ lvarez J, DeDiego ML, Nieto-Torres JL,
Jimenez-Guarden ˜o JM, Regla-Nava JA,
Fernandez-Delgado R, Verdia-Ba ´guena C,
Queralt-Martı ´n M, Kochan G, Perlman S,
Aguilella VM, Sola I, Enjuanes L (2018) Role
of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and
pathogenesis. mBio 9:e2325–e2317
68. Stodola JK, Dubois G, Le Coupanec A,
Desforges M, Talbot PJ (2018) The OC43
human coronavirus envelope protein is critical
for infectious virus production and propagation in neuronal cells and is a determinant of
neurovirulence and CNS pathology. Virology
515:134–149
69. Florek D, Ehmann R, Kristen-Burmann C,
Lemmermeyer T, Lochnit G, Ziebuhr J, Thiel
HJ, Tekes G (2017) Identification and characterization of a Golgi retention signal in feline
coronavirus accessory protein 7b. J Gen Virol
98:2017–2029
70. Gorbalenya AE, Baker SC, Baric RS, de Groot
RJ, Drosten C, Gulyaeva AA, Haagmans BL,
Lauber C, Leontovich AM, Neuman BW,
Penzar D, Perlman S, LLM P, Samborskiy
DV, Sidorov IA, Sola I, Ziebuhr J, Coronaviridae Study Group of the International Committee on Taxonomy of V (2020) The species
severe acute respiratory syndrome-related
coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5:536–544
71. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H,
Wang W, Song H, Huang B, Zhu N, Bi Y,
Ma X, Zhan F, Wang L, Hu T, Zhou H,
Hu Z, Zhou W, Zhao L, Chen J, Meng Y,
Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ,
Wang D, Xu W, Holmes EC, Gao GF, Wu G,
Chen W, Shi W, Tan W (2020) Genomic characterisation and epidemiology of 2019 novel
coronavirus: implications for virus origins and
receptor binding. Lancet 395:565–574
72. Lau SK, Woo PC, Li KS, Tsang AK, Fan RY,
Luk HK, Cai JP, Chan KH, Zheng BJ,
Wang M, Yuen KY (2015) Discovery of a
novel coronavirus, China Rattus coronavirus
HKU24, from Norway rats supports the
murine origin of Betacoronavirus 1 and has
implications for the ancestor of Betacoronavirus lineage A. J Virol 89:3076–3092
PBM-PDZ Interactions and Viral Pathogenesis
235