Table 1
Viral proteins with PBMs and the PDZ domains they interact with
FAMILY
VIRUS
VIRAL PROTEIN
CELLULAR TARGET
PBM
SEQUENCE
Adenoviridae
Human
adenovirus (Ad9)
E4-ORF1
Dlg1, MAGI-1, MUPP1,
PATJ, ZO-2 (77)
…FPSVKIATLV
Hepadnaviridae
HBV
Core Protein
GIPC (78), PTPN3 (79)
…RRSQSRESQC
(non-canonical)
HCV
NS4b
Scribble (20)
…WISSECTTPC
(non-canonical)
Orthomyxoviridae
IAV
NS1
Dlg1, MAGI-1, MAGI-2,
MAGI-3, Scribble (54)
PDLIM2 (80)
…KMARTIESEV
Papillomaviridae
HPV
E6
GAL/GOPC, Dlg1, Dlg4,
MAGI-1, MAGI-2, MAIG-3,
MUPP1, PATJ, PTPN3,
PTPN13, Scribble, TIP-1,
TIP-2/GIPC (16)
…SSRTRRETQL
RhPV
E7
Par3 (81)
…DIVCPSCASRV
Retroviridae
HTLV1
Tax
Dlg1 (82), Scribble (48),
Pro-IL-16 (83)
β1-Syntrophin, Dlg4, Lin-7,
TIP-1, TIP2/GIPC, TIP-40
(19)
MAGI-3 (84), Erbin (85),
MAGI-1 (86)
…SEKHFRETEV
Env
Dlg1(87)
…YSLINPESSL
Flaviviridae
TBEV
NS5
Scribble (61)
RIMS2, ZO-1 (38)
CASK, GIPC, ZO-2,
GRIP2,
Pro-IL-16 (21)
…STHEMYYSTA…
(internal)
…WELRLESSII
DENV
NS5
ZO-1 (38)
…NESDPEGALW
WNV
NS5
HtrA2, OMP25, CLIM1,
ZO-2, PTPN13, PDLIM4,
PDZD2, GRIP2, Scribble,
and others (21)
…DTIVVEDTVL
Rhabdoviridae
RABV
G
Dlg2, MAST2, MUPP1,
PTPN4 (55)
…SHKSGGETRL
Poxviridae
Vaccinia virus
F11
F11 (24)
…LSLSNLDFRL
Coronaviridae
SARS-CoV
E
PALS1 (50), Syntenin (23)
…SSEGVPDLLV
3a
GRIP1
1
, APBA1
1
…EPTTTTSVPL
7b
ND
…QDLEEPCTKV
MERS-CoV
E
Syntenin
1
…KPPLPPDEWF
5
ND
…HIIAPSSLIV
M
ND
…ADIELALLRA
SARS-CoV-2
E
ND
…SSEGVPDLLV
3a
ND
…EPTTTTSVPL
8
ND
…HDVRVVLDFI
ND stands for nondetermined
a
C. Castan ˜o-Rodriguez, E Bailly, P. Zimmermann, JP Borg, L. Enjuanes 2020, unpublished results
220
Carlos Castan ˜ o-Rodriguez et al.