References
1. Nelson WJ (2003) Adaptation of core mechanisms to generate cell polarity. Nature
422:766–774
2. Halaoui R, McCaffrey L (2015) Rewiring cell
polarity signaling in cancer. Oncogene
34:939–950
3. Stephens R, Lim K, Portela M, Kvansakul M,
Humbert PO, Richardson HE (2018) The
scribble cell polarity module in the regulation
of cell signaling in tissue development and
tumorigenesis. J Mol Biol 430:3585–3612
4. Subbaiah VK, Kranjec C, Thomas M, Banks L
(2011) PDZ domains: the building blocks regulating
tumorigenesis.
Biochem
J
439:195–205
5. Ye F, Zhang M (2013) Structures and target
recognition modes of PDZ domains: recurring
themes and emerging pictures. Biochem J
455:1–14
6. Alie ´ A, Manuel M (2010) The backbone of the
post-synaptic density originated in a unicellular
ancestor of choanoflagellates and metazoans.
BMC Evol Biol 10:34
7. Belahbib H, Renard E, Santini S, Jourda C,
Claverie JM, Borchiellini C, Le Bivic A
(2018) New genomic data and analyses challenge the traditional vision of animal epithelium evolution. BMC Genomics 19:393
8. Daulat AM, Puvirajesinghe TM, Camoin L,
Borg JP (2018) Mapping cellular polarity networks using mass spectrometry-based strategies. J Mol Biol 430:3545–3564
9. Pires HR, Boxem M (2018) Mapping the
polarity
interactome.
J
Mol
Biol
430:3521–3544
10. Wen W, Zhang M (2018) Protein complex
assemblies in epithelial cell polarity and asymmetric cell division. J Mol Biol 430:3504–3520
11. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia
SM, Chishti AH, Crompton A, Chan AC,
Anderson JM, Cantley LC (1997) Recognition
of unique carboxyl-terminal motifs by distinct
PDZ domains. Science 275:73–77
12. Hillier BJ, Christopherson KS, Prehoda KE,
Bredt DS, Lim WA (1999) Unexpected
modes of PDZ domain scaffolding revealed by
structure of nNOS-syntrophin complex. Science 284:812–815
13. Awadia S, Huq F, Arnold TR, Goicoechea SM,
Sun YJ, Hou T, Kreider-Letterman G,
Massimi P, Banks L, Fuentes EJ, Miller AL,
Garcia-Mata R (2019) SGEF forms a complex
with scribble and Dlg1 and regulates epithelial
junctions and contractility. J Cell Biol
218:2699–2525
14. Penkert RR, DiVittorio HM, Prehoda KE
(2004) Internal recognition through PDZ
domain plasticity in the Par-6-Pals1 complex.
Nat Struct Mol Biol 11:1122–1127
15. Chetkovich DM, Chen L, Stocker TJ, Nicoll
RA, Bredt DS (2002) Phosphorylation of the
postsynaptic
density-95
(PSD-95)/discs
large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic
targeting of AMPA receptors. J Neurosci
22:5791–5796
16. Clairfeuille T, Mas C, Chan AS, Yang Z, TelloLafoz M, Chandra M, Widagdo J, Kerr MC,
Paul B, Me ´rida I, Teasdale RD, Pavlos NJ,
Anggono V, Collins BM (2016) A molecular
code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex.
Nat Struct Mol Biol 23:921–932
17. Sundell
GN,
Arnold
R,
Ali
M,
Naksukpaiboon P, Orts J, Gu ¨ntert P, Chi CN,
Ivarsson Y (2018) Proteome-wide analysis of
phospho-regulated PDZ domain interactions.
Mol Syst Biol 14:e8129
18. Grant SGN (2019) Synapse diversity and
synaptome architecture in human genetic disorders. Hum Mol Genet 21:219–225
19. Thomas M, Banks L (2018) Upsetting the balance: when viruses manipulate cell polarity control. J Mol Biol 430:3481–3503
20. Franck B (1965) Optical circular dichroism.
Principles, measurements, and applications.
Von L. Velluz, M. Legrand und M. Grosjean.
Angew Chem 77:875–875
21. Greenfield NJ (2006) Using circular dichroism
spectra to estimate protein secondary structure.
Nat Protoc 1:2876–2890
22. Aviv Biomedical, Inc. Circular dichroism spectrophotometer. Instrument manual, 2009
23. Saponaro A (2018) Isothermal titration calorimetry: a biophysical method to characterize
the interaction between label-free biomolecules in solution. Bio-protocol 8:e2957
24. Zhang Y, Yeh S, Appleton BA, Held HA, Kausalya PJ, Phua DC, Wong WL, Lasky LA,
Wiesmann C, Hunziker W, Sidhu SS (2006)
Convergent and divergent ligand specificity
among PDZ domains of the LAP and zonula
occludens (ZO) families. J Biol Chem
281:22299–22311
25. Lim KYB, Go ¨dde NJ, Humbert PO, Kvansakul
M (2017) Structural basis for the differential
interaction of scribble PDZ domains with the
guanine nucleotide exchange factor beta-PIX. J
Biol Chem 292:20425–20436
134
Janesha C. Maddumage et al.
1. Nelson WJ (2003) Adaptation of core mechanisms to generate cell polarity. Nature
422:766–774
2. Halaoui R, McCaffrey L (2015) Rewiring cell
polarity signaling in cancer. Oncogene
34:939–950
3. Stephens R, Lim K, Portela M, Kvansakul M,
Humbert PO, Richardson HE (2018) The
scribble cell polarity module in the regulation
of cell signaling in tissue development and
tumorigenesis. J Mol Biol 430:3585–3612
4. Subbaiah VK, Kranjec C, Thomas M, Banks L
(2011) PDZ domains: the building blocks regulating
tumorigenesis.
Biochem
J
439:195–205
5. Ye F, Zhang M (2013) Structures and target
recognition modes of PDZ domains: recurring
themes and emerging pictures. Biochem J
455:1–14
6. Alie ´ A, Manuel M (2010) The backbone of the
post-synaptic density originated in a unicellular
ancestor of choanoflagellates and metazoans.
BMC Evol Biol 10:34
7. Belahbib H, Renard E, Santini S, Jourda C,
Claverie JM, Borchiellini C, Le Bivic A
(2018) New genomic data and analyses challenge the traditional vision of animal epithelium evolution. BMC Genomics 19:393
8. Daulat AM, Puvirajesinghe TM, Camoin L,
Borg JP (2018) Mapping cellular polarity networks using mass spectrometry-based strategies. J Mol Biol 430:3545–3564
9. Pires HR, Boxem M (2018) Mapping the
polarity
interactome.
J
Mol
Biol
430:3521–3544
10. Wen W, Zhang M (2018) Protein complex
assemblies in epithelial cell polarity and asymmetric cell division. J Mol Biol 430:3504–3520
11. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia
SM, Chishti AH, Crompton A, Chan AC,
Anderson JM, Cantley LC (1997) Recognition
of unique carboxyl-terminal motifs by distinct
PDZ domains. Science 275:73–77
12. Hillier BJ, Christopherson KS, Prehoda KE,
Bredt DS, Lim WA (1999) Unexpected
modes of PDZ domain scaffolding revealed by
structure of nNOS-syntrophin complex. Science 284:812–815
13. Awadia S, Huq F, Arnold TR, Goicoechea SM,
Sun YJ, Hou T, Kreider-Letterman G,
Massimi P, Banks L, Fuentes EJ, Miller AL,
Garcia-Mata R (2019) SGEF forms a complex
with scribble and Dlg1 and regulates epithelial
junctions and contractility. J Cell Biol
218:2699–2525
14. Penkert RR, DiVittorio HM, Prehoda KE
(2004) Internal recognition through PDZ
domain plasticity in the Par-6-Pals1 complex.
Nat Struct Mol Biol 11:1122–1127
15. Chetkovich DM, Chen L, Stocker TJ, Nicoll
RA, Bredt DS (2002) Phosphorylation of the
postsynaptic
density-95
(PSD-95)/discs
large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic
targeting of AMPA receptors. J Neurosci
22:5791–5796
16. Clairfeuille T, Mas C, Chan AS, Yang Z, TelloLafoz M, Chandra M, Widagdo J, Kerr MC,
Paul B, Me ´rida I, Teasdale RD, Pavlos NJ,
Anggono V, Collins BM (2016) A molecular
code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex.
Nat Struct Mol Biol 23:921–932
17. Sundell
GN,
Arnold
R,
Ali
M,
Naksukpaiboon P, Orts J, Gu ¨ntert P, Chi CN,
Ivarsson Y (2018) Proteome-wide analysis of
phospho-regulated PDZ domain interactions.
Mol Syst Biol 14:e8129
18. Grant SGN (2019) Synapse diversity and
synaptome architecture in human genetic disorders. Hum Mol Genet 21:219–225
19. Thomas M, Banks L (2018) Upsetting the balance: when viruses manipulate cell polarity control. J Mol Biol 430:3481–3503
20. Franck B (1965) Optical circular dichroism.
Principles, measurements, and applications.
Von L. Velluz, M. Legrand und M. Grosjean.
Angew Chem 77:875–875
21. Greenfield NJ (2006) Using circular dichroism
spectra to estimate protein secondary structure.
Nat Protoc 1:2876–2890
22. Aviv Biomedical, Inc. Circular dichroism spectrophotometer. Instrument manual, 2009
23. Saponaro A (2018) Isothermal titration calorimetry: a biophysical method to characterize
the interaction between label-free biomolecules in solution. Bio-protocol 8:e2957
24. Zhang Y, Yeh S, Appleton BA, Held HA, Kausalya PJ, Phua DC, Wong WL, Lasky LA,
Wiesmann C, Hunziker W, Sidhu SS (2006)
Convergent and divergent ligand specificity
among PDZ domains of the LAP and zonula
occludens (ZO) families. J Biol Chem
281:22299–22311
25. Lim KYB, Go ¨dde NJ, Humbert PO, Kvansakul
M (2017) Structural basis for the differential
interaction of scribble PDZ domains with the
guanine nucleotide exchange factor beta-PIX. J
Biol Chem 292:20425–20436
134
Janesha C. Maddumage et al.