Table 1
Available hypomorphic M. tuberculosis strains
Strain Name
Gene
Locus
Resistance markers
dnaN-FLAG-tetOn-18
dnaN
Rv0002
Hyg/Strep/Kan
gyrB-FLAG-tetOn-6
gyrB
Rv0005
Hyg/Strep/Kan
gyrA-FLAG-tetOn-10
gyrA
Rv0006
Hyg/Strep/Kan
Rv0013-TetOn 18.1
trpG
Rv0013
Hyg/Strep/Kan
leuS-FLAG-tetOn-6
leuS
Rv0041
Hyg/Strep/Kan
ino1-FLAG-tetOn-10
ino1
Rv0046c
Hyg/Strep/Kan
Rv0066c-TetOn 10.2
icd2
Rv0066c
Hyg/Strep/Kan
gca-FLAG-tetOn-18
gca
Rv0112
Hyg/Strep/Kan
Rv0282-TetOn 10.1
Rv0282 Rv0282
Hyg/Strep/Kan
Rv0283-TetOn18.1
Rv0283 Rv0283
Hyg/Strep/Kan
Rv0289-TetOn 18.1
Rv0289 Rv0289
Hyg/Strep/Kan
Rv0291-TetOn 18.1
mycP3
Rv0291
Hyg/Strep/Kan
Rv0338c-TetOn2.2
Rv0338c Rv0338c
Hyg/Strep/Kan
dnaK-FLAG-tetOn-1
dnaK
Rv0350
Hyg/Strep/Kan
fba-tetOn2
fba
Rv0363c
Hyg/Zeo
def-teton18.1
def
Rv0429c
Hyg/Strep/Kan
Rv0489-TetOn 10.2
gpm1
Rv0489
Hyg/Strep/Kan
proC-TetOn-2.1
proC
Rv0500
Hyg/Strep/Kan
hemA-tetOn-6.3
hemA
Rv0509
Hyg/Strep/Kan
hemC-TetOn6.2
hemC
Rv0510
Hyg/Strep/Kan
hemB-TetOn10.1
hemB
Rv0512
Hyg/Strep/Kan
menE- TetOn 6.1
menE
Rv0542c
Hyg/Strep/Kan
menD-TetOn 18.1
menD
Rv0555
Hyg/Strep/Kan
memH-tetOn-6.1
menH
Rv0558
Hyg/Strep/Kan
rpoB-tetOn-6.1
rpoB
Rv0667
Hyg/Strep/Kan
secY-tetOn-10.1
secY
Rv0732
Hyg/Strep/Kan
desA1-TetOn10.1
desA1
Rv0824c
Hyg/Strep/Kan
Rv0884c-TetOn 6.2
serC
Rv0884c
Hyg/Strep/Kan
mprB-TetOn 6.1
mprB
Rv0982
Hyg/Strep/Kan
metS-FLAG-tetOn-10
metS
Rv1007c
Hyg/Strep/Kan
eno-tetOn2
eno
Rv1023
Hyg/Zeo
(continued)
328
Eachan O. Johnson and Deborah T. Hung