Processes 2019, 7,37
Table 1.
Summary of Section 3: ABM and hybrid models discussed in each section.
3.1. Models Focusing on
Immune-Related Tumor
Mechanobiology
3.2 Models Focusing on
Tumor-Associated Vasculature in
the Immune Response
3.3 Models Focusing on
Tumor-Associated Lymphatics
3.4 Models Focusing on Tumor
Immunotherapy
3.5 Models Focusing on
Tumor-Enhancing Immune Cells
3.6 Models Focusing on
Intra-Tumor Heterogeneity
Study
Ref
Study
Ref
Study
Ref
Study
Ref
Study
Ref
Study
Ref
Cellular adhesion
to ECM
(Frascoli et al.
2016) [89]
Early
metastasis
(Uppal et al.
2017) [92]
Germinal centers
of LN
(Meyer-Hermann
et al. 2002,
2005)
[106–108]
Lung met in
mammary
carcinoma
(Pennisi et al.
2009) [73]
Cancer stem
cell-immune cell
interaction
(Hillen 2013)
(Enderling
2012) [128,129]
Tumor, NK
cell, cytotoxic
T-cell
interactions
(Pourhasanzade et al.
2017) [137]
Adoptive cell
transfer in
colorectal cancer
(Kather et al.
2017) [72]
Immune-epithelial
cell
interactions in
breast
epithelium
(Alfonso et al.
2016) [93]
T-cell behavior in LN
(Bogle et al.
2010, 2012,
2008)
[109–113]
Effect of
vaccine on
lung
metastasis
(Pennisi et al.
2010) [75]
Effect of M1 and
M2 macrophages
on tumor growth
(Wells 2015)
[131]
Effect of
stroma on
tumor spatial
patterns
(Carmona-Fontaine et
al. 2013) [138]
T-cell activation in
virtual LN
(Moreau, 2016)
[113]
Immunotherapy
in solid
tumors
(Dréau et al.
2009) [119]
Signaling between
macrophages and
cancer cells
(Knútsdóttir et
al. 2014, 2016)
[132,133]
Immune cell,
macrophage,
tumor cell
interactions
(Figueredo 2011,
2013) [139,140]
Model of LN to study
cancer vaccines
(Kim et al.
2009) [100]
Role of T-cells
in response to
immunotherapy
(Pappalardo et
al. 2011) [120]
Effect of
macrophages on
TNBC tumor
growth
(Norton et al.
2018) [134]
Tumors under
oxygen-dependent
proliferation
(Figueredo 2013,
2014) [141,142]
Immune response
against viruses
(Jacob et al.
2011) [116]
Effect of
different
therapies on
pancreatic
tumors
(Walker et al.
2016) [123]
Recruitment of APCs
in the LN from lung
(Marino et al.
2011) [117]
Spatio-temporal
dynamics of
tumor-immune
cell
interactions
(Gong et al.
2017) [127]
T-cell trafficking and
proliferation
(Marino et al.
2016) [118]
51
Table 1.
Summary of Section 3: ABM and hybrid models discussed in each section.
3.1. Models Focusing on
Immune-Related Tumor
Mechanobiology
3.2 Models Focusing on
Tumor-Associated Vasculature in
the Immune Response
3.3 Models Focusing on
Tumor-Associated Lymphatics
3.4 Models Focusing on Tumor
Immunotherapy
3.5 Models Focusing on
Tumor-Enhancing Immune Cells
3.6 Models Focusing on
Intra-Tumor Heterogeneity
Study
Ref
Study
Ref
Study
Ref
Study
Ref
Study
Ref
Study
Ref
Cellular adhesion
to ECM
(Frascoli et al.
2016) [89]
Early
metastasis
(Uppal et al.
2017) [92]
Germinal centers
of LN
(Meyer-Hermann
et al. 2002,
2005)
[106–108]
Lung met in
mammary
carcinoma
(Pennisi et al.
2009) [73]
Cancer stem
cell-immune cell
interaction
(Hillen 2013)
(Enderling
2012) [128,129]
Tumor, NK
cell, cytotoxic
T-cell
interactions
(Pourhasanzade et al.
2017) [137]
Adoptive cell
transfer in
colorectal cancer
(Kather et al.
2017) [72]
Immune-epithelial
cell
interactions in
breast
epithelium
(Alfonso et al.
2016) [93]
T-cell behavior in LN
(Bogle et al.
2010, 2012,
2008)
[109–113]
Effect of
vaccine on
lung
metastasis
(Pennisi et al.
2010) [75]
Effect of M1 and
M2 macrophages
on tumor growth
(Wells 2015)
[131]
Effect of
stroma on
tumor spatial
patterns
(Carmona-Fontaine et
al. 2013) [138]
T-cell activation in
virtual LN
(Moreau, 2016)
[113]
Immunotherapy
in solid
tumors
(Dréau et al.
2009) [119]
Signaling between
macrophages and
cancer cells
(Knútsdóttir et
al. 2014, 2016)
[132,133]
Immune cell,
macrophage,
tumor cell
interactions
(Figueredo 2011,
2013) [139,140]
Model of LN to study
cancer vaccines
(Kim et al.
2009) [100]
Role of T-cells
in response to
immunotherapy
(Pappalardo et
al. 2011) [120]
Effect of
macrophages on
TNBC tumor
growth
(Norton et al.
2018) [134]
Tumors under
oxygen-dependent
proliferation
(Figueredo 2013,
2014) [141,142]
Immune response
against viruses
(Jacob et al.
2011) [116]
Effect of
different
therapies on
pancreatic
tumors
(Walker et al.
2016) [123]
Recruitment of APCs
in the LN from lung
(Marino et al.
2011) [117]
Spatio-temporal
dynamics of
tumor-immune
cell
interactions
(Gong et al.
2017) [127]
T-cell trafficking and
proliferation
(Marino et al.
2016) [118]
51