Visionneuse

Date_TXT

2019

Auteur

Ross Carlson, Herbert Sauro

Sujet

biomass reaction; computational biology; macromolecular composition; metabolic model; methods; metabolic network visualization; metabolic modelling; elementary flux modes visualization; flux balance analysis; ADAR; breast; cancer; inosine; microRNA; microRNA targeting; RNA editing; computational model; explanatory model; hybrid model; mechanism; mechanistic model; modeling methods; provenance; workflow; systems modeling; simulation; bioreactor integrated modeling; CFD simulation; compartmental modeling; reduced-order model; bioreactor operation optimization; ordinary differential equation; SREBP-2; nonlinear dynamics; multiple time scales; geometric singular perturbation theory; bifurcation analysis; canard-induced EADs; calcium current; multiscale systems biology; computational biology; quantitative systems pharmacology (QSP); immuno-oncology; immunotherapy; immune checkpoint inhibitor; mathematical modeling; gut microbiota dysbiosis; Clostridium difficile infection; bacterial biofilms; metabolic modeling; parameter optimization; differential evolution; evolutionary algorithm; bistable switch; oscillator; turning point bifurcation; Hopf bifurcation; biological networks; mass-action networks; BioModels Database; n/a

Type de document

Livre

Description :

Modern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics data. A primary goal of this Special Issue, entitled “Methods in Computational Biology”, is the communication of computational biology methods, which can extract biological design principles from complex data sets, described in enough detail to permit the reproduction of the results. This issue integrates interdisciplinary researchers such as biologists, computer scientists, engineers, and mathematicians to advance biological systems analysis. The Special Issue contains the following sections:•Reviews of Computational Methods•Computational Analysis of Biological Dynamics: From Molecular to Cellular to Tissue/Consortia Levels•The Interface of Biotic and Abiotic Processes•Processing of Large Data Sets for Enhanced Analysis•Parameter Optimization and Measurement